Yuchen Lin, Peter F. Zipfel and Christine Skerka*
Age related macular degeneration is a severe disease of mainly elderly people and leads to central vision loss because of the degeneration of the retinal pigment epithelium . Genetic and environmental factors are responsible for the accumulation of extracellular material and deposit formation near the retinal pigment epithelial (RPE) layer, which leads to loss of photoreceptors and induction of chronic inflammation.
Melissa Popowski, Bum-kyu Lee, Cathy Rhee, Vishwanath R Iyer and Haley O Tucker*
Research into regulation of the differentiation of stem cells is critical to understanding early developmental decisions and later development growth. The transcription factor ARID3A previously was shown to be critical for trophectoderm and hematopoetic development.
Arshan Nazempour##, Chrystal R Quisenberry##, Nehal I Abu- Lail and Bernard J Van Wie*
Varied exogenous chondrogenic factors (CFs) are implicated in promoting differentiation of stem cells along a chondrocyte lineage in the field of regenerative tissue engineering for articular cartilage repair. The effects of dexamethasone, transforming growth factor β3 (TGF-β3), ascorbate, and their combinations, on mRNA expression in micromass-cultured human adipose derived stem cells (hADSCs) were investigated as a function of time. Indices include chondrogenic, hypertrophic, angiogenic, fibrogenic and osteogenic markers along with mechanical properties, assessed by atomic force microscopy.
Benetti Federico*, Natalia Scialacomo, Enrique Mariani, Luis Geffner, Bruno Benetti Eng, Daniel Brusich, Yan Duarte and Ernesto Peñaherrera
Introduction: Congestive heart failure is one of the main causes of morbidity and mortality in the XXI century given the promising to date of ABMDSCs and HFDSCs we investigate the safety and effi cacy for the implantation of those stem cells for the treatment of idiopathic cardiomyopathy. This is the fi rst pilot clinical study to assess the safety and feasibility of HFDSC in humans.
Giuseppe Angelico*, Eliana Piombino, Giuseppe Broggi, Fabio Motta and Saveria Spadola
Rhabdomyosarcoma is a soft tissue pediatric sarcoma composed of cells which show morphological, immunohistochemical and ultrastructural evidence of skeletal muscle differentiation. To date four major subtypes have been recognized: embryonal, alveolar, spindle cell/sclerosing and pleomorphic. All these subtypes are defined, at least in part, by the presence of rhabdomyoblasts, i.e. cells with variable shape, densely eosinophilic cytoplasm with occasional cytoplasmic cross-striations and eccentric round nuclei.
Yasuhiro Homma, Arnaud Dubory, Jacques Pariat, Damien Potage, Charles Henri Flouzat Lachaniette, Nathalie Chevallier, Helene Rouard and Philippe Hernigou*
When Total Hip Arthroplasty (THA) is required in a patient with developmental dysplasia of the hip (DDH), bone defi ciency in the acetabular roof often remains a problem. The iliac crest (IC) has long been the preferred source of autograft material, but graft harvest is associated with frequent complications and pain. Autologous bone graft can also be obtained from the femoral head (FH) for reconstruction of the acetabulum in hip arthroplasty.