Yoshihiro Yamada | Editor
Affilation: Aino University School of Health Science, Japan
I started my research career in the study of the host genetic factors involving leukemogenesis in Kyoto Univ, Japan. After finishing my PhD course, I joined Terry Rabbits Lab. in UK to study the role of chromosomal translocation in leukemia. At that time, a lot of important oncogenes/transcription factors have been identified in the chromosomal translocation breakpoints. Lmo2 is one of those oncogenes. During the efforts to clarify the roles of Lmo2 in mouse embryogenesis, we showed the essential role of Lmo2 oncogenes in hematopoiesis and angiogenesis. After coming back to Japan, I have been studying the transcriptional regulation of hematopoiesis/angiogenesis by the Lmo2 transcription factor complex. In angiogenesis study, I am working to develop the methods of regulating tumor growth by inhibiting sprouting angiogenesis.
My research is basically focused on hematological oncology and developmental hematology, in particular, acute lymphoblastic leukemia, chronic myeloid leukemia, and hematopoiesis. Recently, my chief interest has been shifted to the molecular mechanism of angiogenesis.