Research Article

HRCT imaging features of systemic sclerosis-associated interstitial lung disease

Zexuan Zhou, Guangfeng Zhang, Ting Xu, Haobo Lin and Xiao Zhang*

Published: 04/27/2021 | Volume 5 - Issue 1 | Pages: 035-041


Background: The aim of the study was to evaluate radiographic features of systemic sclerosis-associated interstitial lung disease.

Patients and methods: 116 patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) from 2010 to 2019 comprised our retrospective study. All patients were subject to high resolution computed tomography (HRCT). ILD patterns were classified into 7 patterns as IIPs and analyzed with pathology. We chose two staging method and two semi-quantitative score methods to evaluate the HRCT performance and analyzed with pulmonary function tests.

Results: Ground-glass opacities were the most common presentation on HRCT, followed by interlobular septal thickening, reticular opacities, intralobular interstitial thickening; honeycombing, traction bronchiectasis and nodules can also be observed. The most common pattern of SSc-ILD was nonspecific interstitial pneumonia (NSIP), secondly was UIP. There was no difference in ILD pattern between HRCT and pathology, and revealed a high congruence. The four HRCT evaluating methods presented in this study all had significant relationships with PETs.

Conclusion: The most common pattern of SSc-ILD was nonspecific interstitial pneumonia (NSIP). The ILD patterns of HRCT coincide very well with histology, and will replace pathology as the gold standard for diagnosis and evaluation of SSc-ILD.

Read Full Article HTML DOI: 10.29328/journal.jro.1001036 Cite this Article


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