Research Article

Role of HRCT Thorax in pre-operative assessment of RT-PCR COVID-19 negative oral cancer patients

Roopa Ganta, Shehnaz R Kantharia, Bhavin Bhupendra Shah, Rajinikant Mohan Vasava, Tushar Vishnuprasad Vaishnav and Rajesh A Kantharia*

Published: 12/22/2020 | Volume 4 - Issue 3 | Pages: 008-011

Abstract

Background: Oral cancer accounts for 30% of all types of cancer in India. Surgery is the mainstay of treatment but due to the recent outbreak of COVID-19, there is a partial or complete disruption of health services in the country. The initial delay in the treatment was due to cancellations of planned surgeries as per government regulations and reduction in public transportation. In the latter half of the initial relaxation of the lockdown, we formulated our institutional protocol for the surgical treatment of oral cancer patients. On admission, all patients were kept in isolated wards followed by RT-PCR (Reverse Transcriptase-Polymerase Chain Reaction) testing on the same day. RT-PCR negative patients are subjected to HRCT Thorax (High-resolution Computer Tomography). This ensured the safety of health care workers, patients, and patient attendees. Keeping this in mind, we did an observational study on the role of HRCT in the pre-operative screening of asymptomatic oral cancer patients.

Materials and methods: Retrospective analysis of prospectively collected data of 150 patients was done. HRCT reporting was done by two experienced senior radiologists of the Department of Radiology at our hospital.

Results: The number of patients under the CO-RADS 1 category was 121 and CO-RADS 2 category was 29, according to CO-RADS classification. The results of RT-PCR and HRCT were compared and there was a 100% positive correlation between RT-PCR and HRCT Thorax.

Conclusion: Our study supported the use of HRCT Thorax as a diagnostic tool in pre-operative screening of oral cancer patients for COVID 19, particularly in RT-PCR negative cases.

Read Full Article HTML DOI: 10.29328/journal.jro.1001033 Cite this Article

References

  1. Del Rio C, Malani PN. COVID-19-New insights on a rapidly changing epidemic. JAMA. 2020; 323: 1339-1340. PubMed: https://pubmed.ncbi.nlm.nih.gov/32108857/
  2. WHO. Statement on the Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV). Geneva, Switzerland: WHO Newsletter; 2020.
  3. India’s First Coronavirus Case: Kerala Student in Wuhan Tested Positive. Chennai, India: Business Standard News: 2020.
  4. www.deccanherald.com
  5. en.wikipedia.org  
  6. Liang W, Guan W, Chen R, Wang W, Li J, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020; 21: 335-337. PubMed: https://pubmed.ncbi.nlm.nih.gov/32066541/
  7. Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R, Thara S, et al. Effect of screening on oral cancer mortality in Kerala, India: a cluster- randomised controlled trial. Lancet. 2005; 365: 1927–1933. PubMed: https://pubmed.ncbi.nlm.nih.gov/15936419/
  8. Kanne JP, Little BP, Chung JH, Elicker BM, Ketai LH. Essentials for Radiologists on COVID-19: An Update—Radiology Scientific Expert Panel. Radiology. 2020; 296: E113-E114. PubMed: https://pubmed.ncbi.nlm.nih.gov/32105562/
  9. Ai T, Yang Z, Hou H, Zhan C, Chen C, et al. Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 2020; 96: E32-E40. PubMed: https://pubmed.ncbi.nlm.nih.gov/32101510/
  10. Shi H, Han X, Jiang N, Cao Y, Alwalid O, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020; 20: 425-434.
  11. Fang Y, Zhang H, Xie J, Lin M, Ying L, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology. 2020; 296: E115-E117. PubMed: https://pubmed.ncbi.nlm.nih.gov/32073353/