Research Article

8 Gy single dose radiotherapy for bone metastasis in COVID-19 pandemia period: Review

Bora Uysal*, Hakan Gamsız, Ferrat Dincoglan, Omer Sager, Selcuk Demiral and Murat Beyzadeoglu

Published: 05/06/2020 | Volume 4 - Issue 2 | Pages: 005-007

Abstract

Bone metastases in cancer patients are highly painful and decrease the quality of life for these group of population. Covid-19 pandemia is a global challenging issue that mostly affect the patients with immune suppression or having comorbid diseases older than 65 years old. The palliation and management of bone metastases varies from single dose to several fractionation. The main goal of this article is to decide that short or long term fit for the cancer patients with bone metastasis in the Covid-19 era. We reviewed the topic about the short course and long term radiotherapy in the patients with painful bone metastases via novel literature.

Read Full Article HTML DOI: 10.29328/journal.jro.1001032 Cite this Article

References

  1. Latest news. Common questions about coronavirus outbreak. Cancer.
  2. Nielsen OS, Munro AJ, Tannock IF. Bone metastases: pathophysiology and management policy. J Clin Oncol. 1991; 9: 509-524. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1705581
  3. Goblirsch MJ, Zvolak PP, Clohisy DR. Biology of bone cancer pain. Clin Cancer Res. 2006; 12: 6231-6235. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17062706
  4. Zech DF, Grond S, Lynch J, Hertel D, Lehmann KA. Validation of WHO guidelines for cancer pain relief: 10 year prospective study. Pain. 1995; 63: 65-76. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8577492
  5. Wu JS, Wong R, Johnston M, Bezjak A, Whelan T, et al. Meta-analysis of dose-fractionation radiotherapy trials fort he palliation of painful bone metastases. Int J Radiat Oncol Biol Phys. 2003; 55: 594-605. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12573746
  6. Hoskin PJ, Price P, Easton D, Regan J, Austin D, et al. A prospective randomized trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiother Oncol. 1992; 23: 74-78. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1372126
  7. Jeremic B, Shibamato Y, Acimovic L, Milicic B, Milisavljevic S, et al. A randomized trial of three single dose radition therapy regimens in the treatment of metstatic bone pain. Int J Radiat Oncol Biol Phys. 1998; 42: 161-167. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9747834
  8. Steenland E, Leer JW, van Houewelingen H, Post WJ, van den Hout WB, et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone metastases study. Radiother Oncol. 1999; 52: 101-109. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10577695
  9. Hartsell WF, Scott CB, Bruner DW, Scarantino CW, Ivker RA, et al. Randomized trial of short-versus long course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst. 2005; 97: 798-804. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15928300
  10. Ryu S, Pugh SL, Gerszten PC, Yin FF, Timmerman RD, et al. RTOG 0631 Phase 2/3 study of image guided stereotactic radiosurgery for localized spine metastases: phase 2 results. Pract Radiat Oncol. 2014; 4: 76-81. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24890347
  11. Gertzen PC, Burton SA, Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases: clinical experience of 500 cases from a single institution. Spine. 2007; 15: 193-199. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17224814
  12. Steven D, Jennifer T, Peter S, Bressel M, Kelly D, et al. Stereotactic ablative body radiotherapy (SABR) for bone only oligometastatic breast cancer: a prospective clinical trial. Breast. 2020; 49: 55-62. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31734589
  13. Laila AG, Whitney HB, James AH, Mancini B, Jagsi R, et al. Recommendations for single-fraction radiation therapy and stereotactic body radiation therapy in palliative treatment of bone metastasis: a statewide practice patterns survey. Pract Radiat Oncol. 2019; 9: 541-548. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31326530
  14. Shiloh R, Krishnan M. Radiation for treatment of painful bone metastasis. Hematol Oncol Clin North Am. 2018; 32: 459-468. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29729781