Research Article

Parry-Romberg syndrome: A case report of non-invasive treatment

Anahita Dehghani Soltani, Azita Tehranchi, Shiva Safari, Zahra Tehrani and Samin Ghaffari*

Published: 12/30/2019 | Volume 4 - Issue 2 | Pages: 015-020


Parry-Romberg syndrome is an uncommon condition, self-limiting with slow progressive hemifacial atrophy. This syndrome can lead to several progressive congenital and developmental deformities. It can cause severe facial asymmetry and subsequently lead to esthetic and psychological problems and adversely affect patient’s quality of life, so its treatment holds great importance. Still, there is no exact treatment protocol for this disease, treatment approaches are bounded and patient’s response to the treatment is imponderable. However, most of the patients can benefit from conservative treatments. In this paper, we have reported a moderate case of Parry-Romberg syndrome, with no familial history of any syndromes. We also have discussed about present anomalies and the steps of exerted conservative treatments.

Read Full Article HTML DOI: 10.29328/journal.johcs.1001029 Cite this Article


  1. Parry CH. Collections from the Unpublished Medical Writings of the Late Caleb Hillier Parry. Med Chir Rev. 1825; 2. 124-147. PubMed:
  2. Moore T, Southard KA, Casko JS, Qian F, Southard TE. Buccal corridors and smile esthetics. American Journal of Orthodontics and Dentofacial Orthopedics. 2005; 127: 208-213. PubMed:
  3. Al-Khenaizan S, Al-Watban L. Parry-Romberg syndrome: Overlap with linear morphea. Saudi medical journal. 2005; 26: 317-319. PubMed:
  4.  Hickman JW, Sheils WS. Progressive facial hemiatrophy: report of a case with marked homolateral involvement. Arch Intern Med. 1964; 113: 716-720. PubMed:
  5.  Miller M, et al. Progressive hemifacial atrophy (Parry-Romberg disease). Journal of pediatric ophthalmology and strabismus. 1987; 24: 27-36.
  6.  Tolkachjov SN, Patel NG, Tollefson MM. Progressive hemifacial atrophy: A review. Orphanet J Rare Dis. 2015; 10: 39. PubMed:
  7.  Wolf SM. Verity, Neurological complications of progressive facial hemiatrophy. Journal of Neurology, Neurosurgery & Psychiatry. 1974: 37: 997-1004.
  8.  Asher SW. Berg BO. Progressive hemifacial atrophy: report of three cases, including one observed over 43 years, and computed tomographic findings. Arch Neurol. 1982: 39: 44-46. PubMed:
  9. Moss M, Crikelair G. Progressive facial hemiatrophy following cervical sympathectomy in the rat. Arch Oral Biol. 1960; 1: 254-314. PubMed:
  10. Van der Cruyssen F, Van der Cruyssen F, Schoenaersb MJ, Politis C. Parry Romberg syndrome: A long-term retrospective cohort study of 10 patients. Oral and Maxillofacial Surgery Cases. 2018; 4: 73-83.
  11. O’Flynn S, Kinirons M. Parry–Romberg syndrome: a report of the dental findings in a child followed up for 9 years. Int J Paediatr Dent. 2006; 16: 297-301. PubMed:
  12. Zafarulla M. Progressive hemifacial atrophy: a case report. British journal of ophthalmology. 1985; 69: 545-547.
  13. Moko SB, Mistry Y, De Chalain TMB. Parry–Romberg syndrome: intracranial MRI appearances. J Craniomaxillofac Surg. 2003; 31: 321-324. PubMed:
  14. Taylor HM, Robinson R, Cox T. Progressive facial hemiatrophy: MRI appearances. Dev Med Child Neurol. 1997; 39: 484-486. PubMed:
  15. Rischebieth R. Progressive facial hemiatrophy (Parry-Romberg syndrome). Proceedings of the Australian Association of Neurologists. 1976; 13: 109-112.
  16. Mazzeo N, et al. Progressive hemifacial atrophy (Parry-Romberg syndrome) case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 79: 30-35.PubMed:
  17. Menni S, Marzano AV, Passoni E. Neurologic abnormalities in two patients with facial hemiatrophy and sclerosis coexisting with morphea. Pediatr Dermatol. 1997; 14: 113-116. PubMed:
  18. Finesilver B, Rosow HM. Total hemiatrophy. J Am Medical Association. 1938; 110: 366-368.
  19. Miller M, Spencer M. Progressive hemifacial atrophy. A natural history study. Trans Am Ophthalmol Soc. 1995; 93: 203. PubMed:
  20. Rees TD, Ashley FL, Delgado JP. Silicone fluid injections for facial atrophy. Plast Reconstr Surg. 1973; 52: 118-127. PubMed:
  21. Colquhoun A, Ferguson M, Doyle T. Hemifacial atrophy with bilateral short roots. Br J Oral Maxillofac Surg. 2000; 38: 533-536. PubMed:
  22. Foster T. The effects of hemifacial atrophy on dental growth. Br Dent J. 1979; 146: 148-150. PubMed:
  23. Bramley P, Forbes A. A case of progressive hemiatrophy presenting with spontaneous fractures of the lower jaw. Br Med J. 1960; 1: 1476. PubMed:
  24. Glass D. Hemifacial atrophy. Br J Oral Surg. 1963; 1: 194-199. PubMed:
  25. Jun JH. Parry-Romberg syndrome with en coup de sabre. Annals of dermatology. 2011; 23: 342-347.
  26. Gagnier JJ. The CARE guidelines: consensus-based clinical case reporting guideline development. Glob Adv Health Med. 2013; 7: 223. PubMed:
  27. Tang XJ. Parry–Romberg syndrome with rare maxillofacial deformities: A report on two cases. J Craniomaxillofac Surg. 2014; 42: 780-783. PubMed:
  28. Rangare AL. Parry-Romberg syndrome: a rare case report. J Oral Maxillofac Res. 2011; 2. PubMed:
  29. Noden DM. The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Dev Biol. 1983; 96: 144-165. PubMed:
  30. Bronnerā€Fraser M. Mechanisms of neural crest cell migration. Bioessays. 1993; 15: 221-230.
  31. Chai Y. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000; 127: 1671-1679. PubMed:
  32. Pichiecchio A. Parry–Romberg syndrome with migraine and intracranial aneurysm. Neurology. 2002; 59: 606-608. PubMed:
  33. Onesti MG. Minimally invasive combined treatment for Parry-Romberg syndrome. Aesthetic plastic surgery. 2009; 33: 452-456. PubMed:
  34. Stone J. Parry-Romberg syndrome. Practical Neurology. 2006; 6: 185-188.
  35. Wong M. Parry Romberg syndrome: 7 cases and literature review. AJNR Am J Neuroradiol. 2015; 36: 1355-1361. PubMed:
  36. Korkmaz C, Adapinar B, Uysal S. Beneficial effect of immunosuppressive drugs on Parry-Romberg syndrome: a case report and review of the literature. South Med J. 2005; 98: 940-943. PubMed:
  37. De Vasconcelos Carvalho M. Association of aesthetic and orthodontic treatment in Parry-Romberg syndrome. J Craniofac Surg. 2010; 21: 436-439. PubMed:
  38. Roddi R. Clinical evaluation of techniques used in the surgical treatment of progressive hemifacial atrophy. J Craniomaxillofac Surg. 1994; 22: 23-32. PubMed:
  39. Rodby KA. Evaluating Autologous Lipofilling for Parry-Romberg Syndrome–Associated Defects: A Systematic Literature Review and Case Report. Cleft Palate Craniofac J. 2016; 53: 339-350. PubMed:
  40. Raposo-Amaral CE. Parry-Romberg syndrome: severity of the deformity does not correlate with quality of life. Aesthetic Plast Surg. 2013; 37: 792-801. PubMed: