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Volume 3 Issue 2 Volume 3 Issue 1 Volume 2 Issue 2 Volume 2 Issue 1 Volume 1 Issue 1

Recent Articles

2019-07-24 Research Article

Comparative study of carboxylate and amide forms of HLDF-6 peptide: Neuroprotective and nootropic effects in animal models of ischemic stroke

Aim: The work was to perform a comparative study of the neuroprotective and nootropic activities of two pharmaceutical substances, the HLDF-6 peptide and its amide form (HLDF-6-NH2).

Materials and Methods: We used in the study healthy adult male Wis...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001022 Citation

2019-07-31 Research Article

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and inflammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem a...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001023 Citation

2019-08-01 Research Article

Carbonic Anhydrase I modifies SOD1-induced motor neuron toxicity in Drosophila via ER stress pathway

Background: Drosophila models of amyotrophic lateral sclerosis (ALS) have been widely used in understanding molecular mechanisms of ALS pathogenesis as well as discovering potential targets for therapeutic drugs. Mutations in the copper/zinc superoxide dismutase (SOD1) cause A...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001024 Citation

2019-10-01 Research Article

Tamsulosin and Dementia in old age: Is there any relationship?

Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH. By acting on alpha 1A receptors, predom...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001025 Citation

2019-11-04 Review Article

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

The biological changes caused by oxidative stress (OS) are known to be involved in the etiology of neurodegenerative disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease. The brain is particularly vulnerable to...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001026 Citation

2019-11-11 Research Article

Immunohistochemical expression of Nestin as Cancer Stem Cell Marker in gliomas

Background: Gliomas represent the most frequent primary tumors of central nervous system (CNS), contributing to more than half of the incidence of brain tumors. Cancer stem cell markers (CSC) identify a group of patients at high risk for progression. Nestin is an intermediate ...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001027 Citation