Volume 1 Issue 1
2017-09-18 Case Report
Abstract
An enquiry into the lack of attention awarded to serotonin antagonism in the treatment of arterial thrombosis revealed that the mode of action of serotonin and its platelet receptor antagonists was an action upon thrombus growth, and not, as with other anti-platelet drugs upon the initiation of thrombosis. This lack of effect could explain why this approach has been considered not to be effective. However under conditions of arterial stenosis in which there is platelet activation by increased shear stress, and during the growth phase of arterial thrombi, serotonin 5HT2A antagonism has been demonstrated to have great potentcy in dispersing thrombotic obstruction to blood flow. This mode of action, the lack of participation of serotonin in haemostasis, and the absence of serotonin in wounds accounts for the proven lack of effect of effect of pure specific 5HT2A antagonists (i.e., not those with other actions) on operative bleeding and skin bleeding times. This lack of effect on haemostasis solves the dosing problem encountered with other anti-thrombotic drugs, with which drug concentration cannot be controlled with single fixed doses, leading to the association between increased anti-thrombotic efficacy and increased bleeding complications. Thus 5HT2A antagonism appears to be the preferred approach, from the point of view of safety and lack of bleeding risk; this consideration applies particularly to thrombosis therapy in the context of traumatic accidents, surgical operations and invasive procedures such as angioplasty.
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001004 Cite this Article
2017-09-12 Case Report
Abstract
Background: Knowledge of pulmonary complications (PCs) in children after hematopoetic stem cell transplantation (allo-HSCT) is limited; most data are from adult studies.
Case: We describe a 8 year old girl with high risk acute myeloid leukemia who developed graft versus host disease (GVHD) on Day 20, Cytomegalovirus (CMV) pneumonia on Day 50 and Cryptogenic organizing pneumonia (COP) on Day 170 after allo-HSCT.
Discussion: Cryptogenic organizing pneumonia is a rare noninfectious PCs that can be idiopathic or have several risk factors as a secondary causes, such as viral respiratory infections, drugs, GVHD and allo-HSCT. Viral respiratory infections and alloimmune lung syndromes have been reported in a few patients who have undergone transplantation.
Conclusion: Transplant physicians should be kept in mind for the development of alloimmune lung syndrome in the form of COP following CMV pneumonia in patients after allo- HSCT
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001003 Cite this Article
2017-03-30 Editorial
Editorial
Lung cancer is the leading cause of cancer-related deaths worldwide, and almost accounts for 20% of these deaths, however, the cure rate is less than 10% [1]. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases of lung cancer [1], but fewer than 15% of individuals diagnosed with NSCLC can survive for more than 5 years, which poses a great threat to the patient’s life and health [2]. Recently, the incidence of lung cancer keeps dynamically growing, but more than 75% of patients at diagnosis has appeared local development or metastasis, missing the best period of surgery. Moreover, despite surgical treatment is the optimal choice for early-stage NSCLC patients, 30%-40% of patients with NSCLC develop tumor recurrence in a short time. Therefore, improving the prognosis of patients with lung cancer and predicting the long-term survival of patients is of particular importance [3]. At present, tumor and node metastasis (TNM) staging system, clinicopathological characteristics, visceral pleural invasion and marginal status are used to predict the disease progression and overall survival of NSCLC patients. There is no index which is stable, effective, reliable and less harmful to assess prognosis, predict recurrence risk and overall survival.
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001002 Cite this Article
2017-01-09 Review Article
ABSTRACT
Primary cutaneous lymphomas (PCLs) are the second most common group of extranodal non-Hodgkin lymphomas (NHL) with an estimated annual incidence of 1/100.000. Interferons (IFNs) are used in mono or combination therapy for cutaneous lymphomas especially for cutaneous T-cell lymphomas (CTCL) for years. IFN-α is the most widely-used type for cutaneous lymphomas. IFN-α has been shown to be a highly active agent in CTCL with response rates ranging from 40% to 80%. In this review, the current information about PCLs and IFNs treatment is summarized.
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001001 Cite this Article
Recent Articles
2021-06-04 Research Article
FM Monjur Hasan and Richmond Ronald Gomes*
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001017 Citation
2021-04-07 Research Article
Alice Brochier*, Julien Cabo, Claudine Guerrieri, Leïla Belkhir, Pierre-François Laterre and Véronique Deneys*
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001016 Citation
2021-02-10 Research Article
Gaurav Khichariya, Manjula K*, Subhashish Das and Kalyani R
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001015 Citation
2020-12-30 Opinion
2019-09-12 Case Report
Jose Osvaldo Barbosa Neto*, Joao Batista Santos Garcia, Thiago Alves Rodrigues and Camila Freitas de Andrade Rodrigues
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001013 Citation
2019-09-02 Review Article
Vincenzo Accurso*, Santoro M, Contrino AD, Casimiro P, Raso S, Carlisi M, Sardo M, Perez A, Di Piazza F, Russo A and Siragusa S
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001012 Citation
2019-08-08 Research Article
Muhammad Imran Qadir and Sani E Zahra*
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001011 Citation
2019-07-15 Research Article
Khalid Ahmed Al-Anazi*, Al-Anazi WK and Al-Jasser AM
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001010 Citation
2019-07-05 Editorial
Al-Anazi KA* and Al-Jasser AM
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001009 Citation
2019-05-03 Case Report
Al-Anazi KA*, Kanfar S, Aldayel A, Abduljalil O and Sayyed AH
Abstract Read Full Article HTML DOI: 10.29328/journal.jhcr.1001008 Citation