Journal of Genetic Medicine and Gene Therapy

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Volume 1 Issue 1

  • article icon
    Review Article
    Published: 07/25/2017 | Pages: 1(1): 019-036

    The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy

    Jean-Paul Iyombe-Engembe and Jacques P Tremblay*

    Since the discovery of the dystrophin gene (DMD gene) thirty years ago, several therapeutic approaches have been investigated to treat Duchenne muscular dystrophy (DMD). This includes cell therapy, exon jumping, exonic knockout, and the CinDel method. In this article, we present the challenges of developping a treatment for DMD and the advances of these various approaches. We included the new CRISPR-Cas9 system, which permits not only major progress in the development of new treatments based on genome editing but also the production of new animal models.

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    Mini Review
    Published: 07/24/2017 | Pages: 1(1): 003-018

    Progress in the development of Lipoplex and Polyplex modifi ed with Anionic Polymer for effi cient Gene Delivery

    Yoshiyuki Hattori*

    Nucleic acid-based therapy has become an increasingly important strategy for treating a variety of human diseases. In systemic therapy, a therapeutic gene must be delivered effi ciently to its target tissues without side effects. To deliver a therapeutic gene such as plasmid DNA (pDNA) or small interfering RNA (siRNA) to target tissues by systemic administration, cationic carriers such as cationic liposomes and polymers have been commonly used as a non-viral vector.

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    Editorial
    Published: 06/23/2017 | Pages: 1(1): 001-002

    CRISPR genome editing: A general view

    Ram Mohan Ram Kumar*

    CRISPR technology has presented a path forward for genomic engineering and gene modification. The framework for the use of CRISPR technology to manipulate the human genome is of great interest and the form of its development and application has excited the researchers and biotech communities as the number of publications citing CRISPR gene targeting system has rose predominantly as indexed in PubMed.

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