Submitted: 15 December 2019 | Approved: 16 December 2019 | Published: 17 December 2019
How to cite this article: Moreira RM, Barbosa GSB, Dias CB, Yu L, Woronik V, et al. Cytomegalovirus infection in native kidney biopsy. J Clini Nephrol. 2019; 3: 186-186.
Copyright License: © 2019 Moreira RM, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 61-year-old Brazilian black woman consulted with a nephrologist due to proteinuria identified on a routine urine test. She has a personal history of thymoma resection five years ago, followed by multiple episodes of pulmonary infections including mycobacteriosis, recurrent mucocutaneous candidiasis, and paraneoplastic pemphigus. Physical examination showed no edema or hypertension and laboratory tests identified proteinuria of 2.43 g/day without hematuria, serum creatinine of 0.69 mg/dl, urea 34 mg/dl, serum albumin of 2.4 g/dl, hemoglobin 10.9 g/dl, platelets 292,000/mm3, leukocytes 4950/mm3, lymphocytes 594/mm3 and neutrophils 3910/mm3. The hemolysis tests were negative and serum iron was low. Analysis of glicemia and serum lipids levels were normal as well as serum complement and imunoglobulins, except for an IgM level of 283 mg/dl (normal values 40 to 230 mg/dl) and undetectable IgE. Serologies for Syphilis, HIV, hepatitis B, C and antibodies for autoimmune diseases were negative.
A renal biopsy was performed. By light microscopy, the glomeruli showed a Focal and Segmental pattern of Glomerulosclerosis and proximal tubular epithelial cells revealed nuclear and cytoplasmic viral inclusions, typical of cytomegalovirus infection (Figure 1), which was confirmed by positive immunohistochemistry (Figure 2). Imunofluorescence revealed segmental and focal IgM, C3 and C1q with a “trapping” pattern.
Serum PCR for cytomegalovirus (CMV) was positive in low titers. Endoscopic biopsies of gastric ulcers also revealed CMV infection.
Cytomegalovirus infection is reported as a secondary cause of Focal Segmental Glomerulosclerosis (FSGS). However, the presence of cytomegalic inclusions is rarely found in native kidneys and they were reported more often in renal grafts. Therefore, this case is about a patient with Primary Immunodeficiency associated with thymoma, who developed disseminated CMV infection, with involvement of the native kidneys and development of proteinuria due to a secondary FSGS.