Clinical Nephrology is a specialty of medicine that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy including dialysis and kidney transplantation.

The Journal of Clinical Nephrology is an initiative of Heighten Science Publication to publish distinctive and scholarly manuscripts that can play astounding role in enhancing the excellence and confidence of the doctors, scientists and researchers associated in the studies related to renal medicine, hypertension and other related fields of Clinical Nephrology.

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Recent Articles

2021-07-14 Case Report

Acute Kidney Injury due to spontaneous Atheroembolic disease, superimposed on diabetic nephropathy, with no recent vascular or cardiac intervention, presented as Rapidly Progressive Glomerulonephritis (RPGN)

Anas Diab*, Parravani Anthony, Hollie Berryman and Kareem Diab

Atheroembolic disease (AED), or Cholesterol Crystals Embolism, is a systemic disease presented as a complication of severe atherosclerosis [1], where older age, male sex, diabetes hypercholesterolemia, smoking and hypertension [2], are the main risk factors for the development of  Atheroscle...

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2021-05-05 Research Article

Impact of a multidisciplinary pre-dialysis program on renal treatment modalities choice

Luis Miguel Castro Fonseca dos Santos Oliveira*, Rui Arlindo dos Santos Alves de Castro and Teresa Margarida Ribeiro Pinto Morgado

In Portugal, around 2500 patients with end-stage chronic kidney disease (CKD stage 5) start a renal replacement therapy (RRT) for the first time each year [1]. They have four main treatment options: kidney transplantation (TX); haemodialysis (HD); peritoneal dialysis (PD) and conservative treatme...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001073 Cite this Article

2021-04-27 Research Article

Nonlinear relationship between blood glucose and 30-day mortality in critical patients with acute kidney injury: A retrospective cohort study

Qilin Yang, Weichao Huang, Xiaomei Zeng, Jiezhao Zheng, Weixiao Chen and Deliang Wen*


Background: Acute kidney injury (AKI) is a major health problem affecting millions of people worldwide. Effective preventative and therapeutic treatments remain to be produced. We aim to determine the association between blood glucose and mortality in critical patients with A...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001072 Cite this Article

2021-04-27 Research Article

Prognostic factors for chronic kidney disease and end-stage renal disease in patients with lupus nephritis: A retrospective cohort study

Fernanda Nogueira Holanda Ferreira Braga*, Marta Maria das Chagas Medeiros, Antônio Brazil Viana Jr., Levi Coelho Maia Barros, Marcelo Ximenes Pontes, Matheus Eugênio de Sousa Lima, Allyson Wosley de Sousa Lima and Paula Frassinetti Castelo Branco Camurça Fernandes


Background: Lupus Nephritis (LN) occurs in approximately half of all patients with Systemic Lupus Erythematosus (SLE) and it is the most common cause of morbidity and mortality in patients with SLE. Factors associated with poor renal outcome vary among studies, and researches...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001071 Cite this Article

2021-04-22 Case Report

Diffuse alveolar hemorrhage: Unusual presentation of systemic lupus erythematosus

Zajjari Yassir*, Sobhi Aya, Aatif Taoufiq, Azizi Mounia and El Kabbaj Driss

Diffuse alveolar hemorrhage (DAH) is a rare complication of systemic lupus erythematosus (SLE) and carries a high mortality.

It was first described by Osler in 1904 as the most devastating pulmonary complication of SLE.

We describe a case of a 23-year-old girl recently diagnos...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001070 Cite this Article

2021-04-08 Research Article

Collecting duct PGE2 responses reduce water loss with empagliflozin in mice with type 2 diabetes mellitus

R Nasrallah, J Zimpelmann, V Cheff, JF Thibodeau, KD Burns and RL Hébert*


Introduction: Sodium-glucose cotransporter 2 inhibitors such as empagliflozin (EMPA) protect against diabetic kidney disease. Prostaglandin E2 (PGE2) the main renal product of cyclooxygenase-2, inhibits vasopressin (AVP)-water reabsorption in the collecting duct (CD). The nov...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001069 Cite this Article

2021-03-08 Case Report

Prostate cancer-associated thrombotic microangiopathy: A case report and review of the literature

HHS Kharagjitsing*, PAW te Boekhorst and Nazik Durdu-Rayman


Background: Thrombotic microangiopathy (TMA) is a rare and life-threatening complication of prostate carcinoma. Whether plasma exchange has a role in treatment remains a subject of debate. Here we present a case followed by a systematic review of the literature on this subjec...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001068 Cite this Article

2021-03-08 Research Article

Incidence and risk factors of vancomycin-associated acute kidney injury in a single center: Retrospective study

Tanuja Yalamarti, Shahrzad Zonoozi*, Kwabena Adu Ntoso and Pooneh Alborzi


Background: There is enough evidence to suggest that vancomycin increases the risk of acute kidney injury (AKI) but the exact mechanism is not well understood. This study aims to understand the incidence of vancomycin-associated acute kidney injury (VA-AKI) among hospitalized...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001067 Cite this Article

2021-01-20 Clinical Image

Hyperacute fatal course in a hypercalcemic crisis

Sara Turco*, Alice Chiara Manetti, Aniello Maiese, Matteo Scopetti and Marco Di Paolo

Clinical Image

A 39-year-old woman, with a not significant past medical history, entered the Emergency Department complaining about nausea, vomiting, constipation, anorexia, deep asthenia, and diffuse muscle aches with cramps. She referred sporadic diarrhea (one episode) the day befor...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001066 Cite this Article

2021-01-12 Research Article

Glomerular hyperfiltration in Yemeni children with sickle cell disease

Abdul-Wahab M Al-Saqladi* and Fatima E Al-Musawa


Background: Glomerular hyperfiltration (GH) is a common feature of sickle cell nephropathy (SCN) starting at infancy and represents an early marker of incipient glomerular injury and renal dysfunction.

Methods: This study aimed to determine the prevalence and correl...

Abstract Read Full Article HTML DOI: 10.29328/journal.jcn.1001065 Cite this Article