Research Article

Cystic Micronodular Thymoma. Report of a Case

Mona Mlika*, Adel Marghli and Faouzi Mezni

Published: 01/20/2017 | Volume 1 - Issue 1 | Pages: 001-004

ABSTRACT

Micronodular thymoma is a rare subtype of thymoma with less than 20 cases published in the English literature. These tumours have been reported with thymoma or thymic cyst. The authors describe a new case of micronodular thymoma in a 68-year-old-patient which is well documented and particular by its cystic degeneration which hasn’t been described yet. Micronodular thymoma is a rare variant of thymoma with a challenging diagnosis. Clinicians must be aware of this entity in order not to confuse it with a thymic cyst.

Read Full Article HTML DOI: 10.29328/journal.jcmei.1001001 Cite this Article

REFERENCES

  1. Marx A, Chan JK, Coindre JM, Detterbeck F, Girard N, et al. The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. J Thorac Oncol. 2015; 10: 1383-1395. Ref.: https://goo.gl/xA01c1
  2. Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, et al. Multilocular Thymic Cyst Associated With Thymoma. A Clinicopathologic Study of 20 Cases With an Emphasis on the Pathogenesis of Cyst Formation. Am J Surg Pathol. 2012;  36: 1857-1864. Ref.: https://goo.gl/W0MJrd
  3. Marx A, Ströbel Ph, Marino M, Eimoto T, Harris NL, et al. Tumours of the thymus-Thymomas. Chapter 3. Micronodular thymoma with lymphoid stroma. 167-168.
  4. Suster S, Moran CA. Micronodular thymoma with lymphoid B-cell hyperplasia. clinicopathologic and immunohistochemical study of eighteen cases of a distinctive morphologic variant of thymic epithelial neoplasm. Am J Surg Pathol. 1999; 23: 955-962. Ref.: https://goo.gl/87Zfas
  5. Suster S, Rosai J. Cystic thymomas. A clinicopathlogic study of ten cases. Cancer. 1992; 69: 92-97. Ref.: https://goo.gl/fpt38W
  6. Planelles A, Aranda FI, Córdoba C, Aboumar A, Payá A. Micronodular thymoma with lymphoid B-cell hyperplasia. Report of a case. Rev Esp Patol. 2007; 40: 113-116.
  7. Strobel P, Marino M, Feuchtenberger M, Rouzière AS, Tony HP, et al. Micronodular thymoma. an epithelial tumour with abnormal chemokine expression setting the stage for lumphoma development. J Pathol. 2005; 207: 72-82. Ref.: https://goo.gl/o2YLMH
  8. Tateyama H, Saito Y, Fujii Y, Okumura M, Nakamura K,  et al. The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia. Histopathology. 2001; 38: 519-527. Ref.: https://goo.gl/Xbyl9V
  9. Zhu P, Yan F, Ao Q. Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report. Int J Clin Exp Pathol. 2014; 7: 7262-7267. Ref.: https://goo.gl/21Elhb
  10. Chen CW, Chuang SS, Pan ST. Micronodular Thymoma with Lymphoid Stroma Diagnosed with Core Needle Biopsy. A Case Report. Anal Quant Cytopathol Histpathol. 2015; 37: 206-210. Ref.: https://goo.gl/YtLZUm
  11. Cha YJ, Han J, Kim J, Lee KS, Shim YM. A rare case of mixed type a thymoma and micronodular thymoma with lymphoid stroma. J Pathol Transl Med. 2015; 49: 75-77. Ref.: https://goo.gl/4jCr2z  
  12. Kim NR, Lee JI, Ha SY. Micronodular thymoma with lymphoid stroma in a multilocular thymic cyst: a case study. Korean J Pathol. 2013; 47: 392-394. Ref.: https://goo.gl/4pp4I4