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Volume 1 Issue 1

  • article icon
    Editorial
    Published: 07/31/2017 | Pages: 1(1): 024-027

    Paediatric Medicines: Formulation Considerations

    Fátima Roque*

    The use of unlicensed and off-label medicines in children is widespread and has raised an increasing concern over the last years. The majority of medicines taken by children are extemporaneously compounded by pharmacist, and there is a lack of information regarding bioavailability, suitability and stability. These formulations must be prepared from pure active substance and not from commercially available dosage forms.

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    Research Article
    Published: 07/07/2017 | Pages: 1(1): 013-023

    Sense and antisense Oligodeoxynucleotides to Glun1 Nmdar are Cognitive Enhancers (Nootropics) and protective agents in normal and ischemic (Anoxic) conditions-In vitro study

    Anatoly A Mokrushin*

    Aims: Implication of modifi ed N-methyl-D-aspartate receptors (NMDAR)  in synaptic plasticity and learning was investigated in normal and pathological conditions

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    Research Article
    Published: 01/25/2017 | Pages: 1(1): 007-012

    A Further Example Showing Efficiency of a Modeling Method Based on the Theory of Dynamic Systems in Pharmacokinetics

    Maria Durisova*

    Aims: To present a further example showing an efficiency of a modeling method based on the theory of dynamic systems in pharmacokinetics.
    Study design: The goals of the current study were twofold: to present (1) a further example showing efficiency of a modeling method based on the theory of dynamic systems in pharmacokinetics, and to perform (2) a next step in tutoring the use of computational and modeling tools from the theory of dynamic systems in pharmacokinetics.

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    Research Article
    Published: 01/24/2017 | Pages: 1(1): 001-006

    Kinematics and Electromyographic Analysis of Gait with Different Footwear

    Carlos Alberto Kelencz*, Ingrid Solange Sepúlveda Muñoz, Paulo Rui de Oliveira, Bruno Mazziotti and Cesar Ferreira Amorim

    Kinematic analysis and surface electromyography are tools being used as important methods to evaluate the human gait and to analyze different types of footwear aiming modifications and adaptations to the human locomotor system, especially of the feet. The aim of the present study was to analyze through electromyography (EMG) the muscles tibialis anterior (TA) and gastrocnemius lateralis (GL) and gastrocnemius medialis (GM) and to capture digital images of the human gait in four different footware situations, barefoot with tennis, platform shoes and high heels.

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