Volume 1 Issue 1
2017-10-11 Research Article
ATPases is known to be a crucial in many biological activities of organisms. In this study, physicochemical properties and modeling of ATPases protein of fish was analysed using In silico approach. ATPases a protein selected from fish species, including Gold fish (Carassius auratus auratus), Zebra fish (Hypancistrus zebra), White fishes (Coregonus autumnalis), Grass carp (Ctenopharyngodon idella) and Anabas testudineus (Koi) were used in this study. Physicochemical characteristics showed with molecular weight (25045.58-25148.57Da), theoretical isoelectric point (9.30-9.97), extinction coefficient(26470-34950), aliphatic index(147.31-150.35), instability index(32.84-42.67), total number of negatively charged residues and positively charged residues (5/7-6/8), and grand average of hydropathicity (1.014-1.151) were computed. All proteins were classified as transmembrane proteins. In secondary structure prediction, all proteins were composed of random coils as predominant, followed by extended strands, alpha helix and beta turn. Three dimensional structure of protein were predicted and verified as good structures. All model structures were evaluated being accepted and reliable based on structural evaluation and stereo chemical analysis.
Abstract Read Full Article HTML DOI: 10.29328/journal.hpbr.1001003 Cite this Article
2017-08-28 Review Article
This review gives a brief introduction to the microarray technology and its experimental design and data analysis and a discussion of recent global progress in research using microarray technology in fish biology and aquaculture. DNA microarrays have been reported to have been used for the analysis of gene expression during various physiological, developmental or cellular processes in fish. During the recent past, investigators have begun to use microarrays on fish to address ecological, evolutionary and environmental questions including the variability of gene expression in natural populations, speciation, ecotype diversity, environmental remediation and host-pathogen interactions. The study suggests that a lot of gene expression studies have been conducted on salmon and zebrafish in Europe and USA. The same may be applied on Indian Major Carps and Catfishes to augment productivity from aquaculture sector.
Abstract Read Full Article HTML DOI: 10.29328/journal.hpbr.1001002 Cite this Article
2017-06-23 Short Communication
Protein functional annotation requires time and effort, while sequencing technologies are fast and cheap. For this reason, the development of software tools aimed at predicting protein function from sequences can help in protein annotation.
In this paper, we describe how to use our recently implemented Bologna Annotation Resource (BAR) version 3.0, a tool based on over 30 million protein sequences for protein structural and functional annotation. In BAR 3.0, sequences are arranged in a similarity graph and then clustered together when they share at least 40% sequence identity over 90% of sequence alignment, for a total of 1,361,773 clusters.
Protein sequences with known function transfer their annotation to other sequences in the same cluster after statistical validation. Sequences with unknown function and new sequences entering in a cluster inherit its statistically validated annotations.
The method well compares to other techniques in the Critical Assessment of protein Function Annotation algorithms (CAFA). The CAFA experiment tests the performances of different predictors on a dataset that accumulates annotations over time. BAR predictions have been submitted to all the instances of CAFA through the years (BAR Plus in CAFA, BAR++ in CAFA2 and BAR 3.0 in CAFA3). The benchmarking indicates that in the field improvement is still possible and that our BAR scores among the top performing methods.
This work focuses on how the tool can transfer statistically significant features to poorly annotated or new sequences derived from transcrptomics or proteomics experiments.
Abstract Read Full Article HTML DOI: 10.29328/journal.hpbr.1001001 Cite this Article
2021-07-20 Research Article
The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy
Luisetto M*, Tarro G, Khaled Edbey, Almukthar N, Cabianca L, Mashori GR, Ahnaf Ilman, Yesvi AR and Latyschev OY
2021-06-14 Review Article
Pigeonpea sterility mosaic virus a green plague-Current status of available drug and new potential targets
Nisha Singh*, Bhawna Narula, Megha Ujinwal and Sapna Langyan
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001013 Citation
2021-04-08 Research Article
A Mishra*, AV Shestopalov, AM Gaponov, IA Alexandrov and SA Roumiantsev
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001012 Citation
2020-07-03 Research Article
Vandna Kumari and Shamsher Singh Kanwar*
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001011 Citation
2020-02-11 Research Article
Noor Muhammed Noori* and Omar Saber Qasim
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001010 Citation
2020-01-30 Review Article
Classification of diseases using a hybrid fuzzy mutual information technique with binary bat algorithm
Firas Ahmed Yonis AL-Taie* and Omar Saber Qasim
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001009 Citation
2019-12-31 Research Article
The importance of gestational age in first trimester, maternal urine MALDI-Tof MS screening tests for Down Syndrome
Ray K Iles*, Nicolaides K, Pais RJ, Zmuidinaite R, Keshavarz S, Poon LCY and Butler SA
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001008 Citation
2019-12-19 Research Article
Theoretical study on binding interactions of laccase-enzyme from Ganoderma weberianum with multiples ligand substrates with environmental impact
Yosberto Cárdenas-Moreno*, Luis Ariel Espinosa, Julio Cesar Vieyto, Michael González-Durruthy, Alberto del Monte-Martinez, Gilda Guerra-Rivera and Maria Isabel Sánchez López
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001007 Citation
Md. Mehedi Hasan* and Mst. Shamima Khatun
Abstract Read Full Article HTML DOI: 10.29328/journal.apb.1001005 Citation