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Volume 1 Issue 1

  • article icon
    Review Article
    Published: 08/31/2017 | Pages: 1(1): 024-034

    Overweight, Obesity and Physical activity in relation to Follicular Lymphoma incidence and Mortality: A meta-analysis

    Ilija Golubovic, Goran Marjanovic, Danijela Radojkovic, Dusan Sokolovic, Aleksandar Karanikolic and Radojkovic Milan

    Purpose: In the last few years there has been a growing interest in exploring the association between risk factors such as overweight, obesity and physical activity, and incidence of various cancers.

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    Case Report
    Published: 07/17/2017 | Pages: 1(1): 018-023

    A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain

    Zuhal Bayramoglu*, Ravza Yılmaz and Aysel Bayram

    This report presents an adult patient suffering from sacroiliitis like low back pain, lumbosacral radiculopathy and elbow swelling. Multimodality imaging revealed multiple lytic bone lesions located in supra acetabular iliac bone, sacrum, and distal end of radius. Painful numerous lesions due to the extension to the articular surfaces are not expected for Brown tumors.

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    Review Article
    Published: 06/27/2017 | Pages: 1(1): 009-017

    MicroRNA Therapeutics in Triple Negative Breast Cancer

    Sarmistha Mitra*

    Breast cancer is a complex disease and one of the main causes of cancer-related mortality in women worldwide. In case of approximately 15% of all breast cancers, three markers i.e. estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptors-2 (HER2) are not express, and is commonly termed as triple-negative breast cancer (TNBC). Particularly, TNBC is associated with a higher percentage of breast cancer related mortality, which is often aggressive and most frequently found with a BRCA1 mutation or increased basal marker expression.

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    Case Report
    Published: 06/12/2017 | Pages: 1(1): 005-008

    Hypernatremia and central Diabetes Insipidus following Neurosurgical procedure of Trauma

    Awad Magbri*, Eussera El-Magbri and Seth Hershit

    The greater risk of hypernatremia in patients over 65 years old are associated with impaired mental status and physical disability which may result in impaired sensation to thirst, impaired ability to express thirst, and/or decrease access to water [1,2]. Normally, anti-diuretic hormone (ADH, also known as arginine-vasopressin, AVP) is secreted in response to 1-2% increase in osmolality which stimulate thirst, as do hypovolemia and hypotension.

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    Short Communication
    Published: 01/30/2017 | Pages: 1(1): 001-004

    Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour

    Anjali Ganjre*

    Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was definite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC.

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