Research Article

Longitudinal and transverse dimensions of Hypertrophied Cardiomyocytes in human Left Ventricle (LV) at autopsy; Heart failure might result from changes in chamber geometry without contractile weakening

Richard E Tracy*

Published: 07/23/2019 | Volume 3 - Issue 1 | Pages: 015-019

Abstract

The shapes and sizes of human cardiomyocytes are accessible to systematic observation under most circumstances only at autopsy. This constraint has seriously curbed the study of these topics, thereby leaving a crippling gap in our understanding of heart failure. In recent years the only published ongoing findings have come from this laboratory. This article is a condensation of these reports, using those sources to develop fresh analyses designed to construct a set of organizing principles. The data are entirely retrospective thereby forbidding hypothesis testing and permitting only hypothesis formation. The hypotheses generated in this way are novel and surprising. In spite of the severe limitations in this methodology is seems possible that some useful new directions of inquiry might evolve from pursuing these original observations.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001013 Cite this Article

References

  1. Tracy RE, Sander GE. Histologically measured cardiomyocyte hypertrophy correlates with body height as strongly as with body mass index.  Cardiol Res Pract. 2011; 2011: 658958. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21738859
  2. Tracy RE. Cardiomyocyte size estimated from noninvasive measurements of left ventricular wall thickness and chamber diameter. J Amer Soc Hypertens. 2012; 6: 185-192. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22417735
  3. Tracy RE. Eccentric may differ from concentric left ventricular hypertrophy because of variations in cardiomyocyte numbers. J Card Failure. 2013; 19: 517-522. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23834928  
  4. Tracy RE. Cardiac myocyte sizes in right compared with left ventricle during overweight and hypertension. J Amer Soc Hypertens. 2014; 8: 457-463. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25064767
  5. Tracy RE. Heart failure and limit to cardiomyocyte hypertrophy: Lessons from autopsies. Eur J Forensic Sci. 2016.
  6. Tracy RE. Limit to cardiomyocyte hypertrophy in right and left ventricles: Possible precursors of systolic heart failure. J Forensic Research. 2016; 7: 1000345.
  7. Karsner HT, Saphir O, Todd TW. The State of the cardiac muscle in hypertrophy and atrophy. Am J Pathol. 1925; 1: 351-372. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19969656
  8. Linzbach AJ. Heart failure from the point of view of quantitative anatomy. Am J Cardiol. 1960; 5: 370-382. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14417346
  9. Gerdes AM. Cardiac myocyte remodeling in hypertrophy and progression to failure. J Card Fail. 2002; 8: S264-S268. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12555130
  10. Devereux RB. Echocardiographic insights into the pathophysiology and prognostic significance of hypertensive cardiac hypertrophy. AmJ Hypertens. 1989; 2: 186S-195S. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2526645
  11. De Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, et al. Assessment of left ventricular function by the mid wall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol. 1994; 23: 1444-1451.
  12. Streeter DD, Spotnitz HM, Pate DP, Ross J Jr, Sonnenblick EH. Fiber Orientation in the Canine Left Ventricle during Diastole and Systole. Circ Res. 1969; 24: 339-347. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/5766515
  13. Tamura T, Onodera T, Said S, Gerdes AM. Correlation of myocyte lengthening to chamber dilation in the spontaneously hypertensive heart failure (SHHF) rat. J Mol Cell Cardiol. 1998; 30: 2175-2181. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9925355
  14. Tracy RE. Renal vasculature in essential hypertension: a review of some contrarian evidence. Contrib Nephrol. 2011; 169: 327-336. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21252530