Research Article

Rosai-Dorfman disease presenting as a breast mass

Ding Dai*#, Qi Cai#, Nasreen A. Vohra, Jan Wong, Zsuzsanna P. Therien, Karlene Hewan-Lowe and Ann Sutton

Published: 03/18/2019 | Volume 3 - Issue 1 | Pages: 008-014

Abstract

Rosai-Dorfman disease (RDD) is an idiopathic, benign proliferation of histiocytes that can be present in multiple organs such as lymph node, skin, soft tissue, orbit, central nerve system and bone; however, it rarely occurs in the breast. In general, RDD is a painless, firm and poorly defined lesion, which can radiologically mimic a breast cancer and is therefore an important differential consideration. The diagnosis of breast RDD is challenging, especially on a small biopsy specimen. We report a unique case of breast RDD with a literature review including common presentation, differential diagnosis, and recommended management. A high index of suspicion for this rare entity is essential to render a correct diagnosis, thereby avoiding unnecessary diagnostic tests and treatment.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001012 Cite this Article

References

  1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 1969; 87: 63-70. Ref.: https://goo.gl/EmbgZ1
  2. Eisen RN, Buckley PJ, Rosai J. Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol. 1990; 7: 74-82. Ref.: https://goo.gl/Ezi5o9
  3. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990; 7: 19-73. Ref.: https://goo.gl/MxVVWu
  4. Green I, Dorfman RF, Rosai J. Breast involvement by extranodal Rosai-Dorfman disease: report of seven cases. Am J Surg Pathol. 1997; 21: 664-668. Ref.: https://goo.gl/SvL9rt
  5. Mac-Moune Lai F, Lam WY, Chin CW, Ng WL. Cutaneous Rosai-Dorfman disease presenting as a suspicious breast mass. J Cutan Pathol. 1994; 21: 377-382. Ref.: https://goo.gl/BKZXsx
  6. Perera AS, Keleher AJ, Nath M. Rosai-Dorfman disease presenting as a male breast mass. Am Surg. 2007; 73: 294-295. Ref.: https://goo.gl/3bcRKs
  7. Bansal P, Chakraborti S, Krishnanand G, Bansal R. Rosai-Dorfman disease of the breast in a male: a case report. Acta Cyto. 2010; 54: 3493-3452. Ref.: https://goo.gl/j9W7bu
  8. Pérez-Guillermo M, Sola-Pérez J, Rodríguez-Bermejo M. Malacoplakia and Rosai-Dorfman disease: two entities of histiocytic origin infrequently localized in the female breast--the cytologic aspect in aspirates obtained via fine-needle aspiration cytology. Diagn Cytopathol. 1993; 9: 698-704. Ref.: https://goo.gl/q3Z91J
  9. Ng SB, Tan LH, Tan PH. Rosai-Dorfman disease of the breast: a mimic of breast malignancy. Pathology. 2000; 32: 10-15. Ref.: https://goo.gl/j6RXLP
  10. Baladandapani P1, Hu Y, Kapoor K, Merriam L, Fisher PR. Rosai-Dorfman disease presenting as multiple breast masses in an otherwise asymptomatic male patient.  Clin Radiol. 2012; 67: 393-395. Ref.: https://goo.gl/VuqCjE
  11. Cha YJ, Yang WI, Park SH, Koo JS. Rosai-Dorfman Disease in the breast with increased IgG4 expressing plasma cells: a case report. Korean J Pathol. 2012; 46: 489-493. Ref.: https://goo.gl/HCxnoa
  12. Delaney EE, Larkin A, MacMaster S, Sakhdari A, DeBenedectis CM. Rosai-Dorfman disease of the breast mimicking cancer. Pathol Res Pract. 2007; 203: 741-744. Ref.: https://goo.gl/Wqueng
  13. Kuzmiak CM, Koomen M, Lininger R, Pisano E. Rosai-Dorfman disease presenting as a suspicious breast mass. AJR Am J Roentgenol. 2003; 180: 1740-1742. Ref.: https://goo.gl/XCrwZ4
  14. Wu YC, Hsieh TC, Kao CH, Chang HW, Wang CH, et al., A mimic of breast lymphoma: extranodal Rosai-Dorfman disease. Am J Med Sci. 2010; 339: 282-284. Ref.: https://goo.gl/vcAHFa
  15. Fu L, Liu M, Song Z, Xu B, Tian J. 18F-fluoro-deoxyglucose positron emission tomography/computed tomography scan findings in Rosai-Dorfman disease with IgG4positive plasma cell infiltration mimicking breast malignancy: a case report and literature review. J Med Case Rep. 2012; 30: 411. Ref.: https://goo.gl/zxixCc
  16. Morkowski JJ, Nguyen CV, Lin P, Farr M, Abraham SC, et al., Rosai-Dorfman disease confined to the breast. Ann Diagn Pathol. 2010; 14: 81-87. Ref.: https://goo.gl/9ZN1f2
  17. Hammond LA, Keh C, Rowlands DC. Rosai-Dorfman disease in the breast, Histopathology. 1996; 29: 582-584. Ref.: https://goo.gl/cH42MS
  18. Soares FA, Llorach-Velludo MA, Andrade JM. Rosai-Dorfman’s disease of the breast. Am J Surg Pathol. 1999; 23: 359-360. Ref.: https://goo.gl/1ApvRj
  19. Hummel P, Waisman J, Chhieng D, Yan Z, Cohen JM, et al. Fine-needle aspiration cytology of RosaiDorfman disease of the breast: A case report. Diagn Cytopathol. 1999; 21: 287-291. Ref.: https://goo.gl/YjYaSf
  20. Foucar E, Rosai J, Dorfman RF, Eyman JM. Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy. Am J Clin Pathol. 1984; 82: 515-525. Ref.: https://goo.gl/zcjwRX
  21. Chen TD, Lee LY, Rosai-Dorfman disease presenting in the parotid gland with features of IgG4-related sclerosing disease. Arch Otolaryngol Head Neck Surg. 2011; 137: 705-708. Ref.: https://goo.gl/kgcHfo
  22. Roberts SS, Attanoos RL. IgG4+ Rosai-Dorfman disease of the lung. Histopathology. 2010; 56: 662-664. Ref.: https://goo.gl/GpYz4E
  23. Liu L, Perry AM, Cao W, Smith LM, Hsi ED, et al. Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases. Am J Clin Pathol. 2013; 140: 395-402. Ref.: https://goo.gl/urEMPC
  24. McClain KL, Natkunam Y, Swerdlow SH. Atypical cellular disorders. Hematology Am Soc Hematol Educ Program. 2004; 283-296. Ref.: https://goo.gl/DHdPHf
  25. Paulli M, Rosso R, Kindl S, Boveri E, Marocolo D, et al. Immunophenotypic characterization of the cell infiltrate in five cases of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Hum Pathol. 1992; 23: 647-654. Ref.: https://goo.gl/6RkqJA
  26. Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. An analysis of 14 deaths occurring in a patient registry. Cancer. 1984; 54: 1834-1840. Ref.: https://goo.gl/t4gm98
  27. Chen J, Tang H, Li B, Xiu Q. Rosai-Dorfman disease of multiple organs, including the epicardium: An unusual case with poor prognosis. Heart Lung. 2011; 40: 168-171. Ref.: https://goo.gl/keLLZ1
  28. Tenny SO, McGinness M, Zhang D, Damjanov I, Fan F. Rosai-Dorfman disease presenting as a breast mass and enlarged axillary lymph node mimicking malignancy: a case report and review of the literature. Breast J. 2011; 17: 516-520. Ref.: https://goo.gl/AWJ2qc
  29. Mantilla JG, Goldberg-Stein S, Wang Y. Extranodal Rosai-Dorfman Disease: Clinicopathologic Series of 10 Patients with Radiologic Correlation and Review of the Literature. Am J Clin Pathol. 2016; 145: 211-221. Ref.: https://goo.gl/wumbRy
  30. Pulsoni A, Anghel G, Falcucci P, Matera R, Pescarmona E, et al., Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol. 2002; 69: 67-71. Ref.: https://goo.gl/bM22z6
  31. Gwin K, Cipriani N, Zhang X, Schmidt R, Hyjek E. Bilateral breast involvement by disseminated extranodal Rosai-Dorfman disease. Breast J. 2011; 17: 309-311. Ref.: https://goo.gl/UrRwMN
  32. Parkin CKE, Keevil C, Howe M, Maxwell AJ. Rosai-Dorfman disease of the breast. BJR Case Rep. 2015; 1: 20150010. Ref.: https://goo.gl/rNkXY8
  33. Zhou Q, Ansari U, Keshav N, Davis D, Cundiff M. Extranodal manifestation of Rosai-Dorfman disease in the breast tissue. Radiol Case Rep. 2016; 17: 125-128. Ref.: https://goo.gl/chou1p
  34. Delaney EE, Larkin A, MacMaster S, Sakhdari A, DeBenedectis CM. Rosai-Dorfman Disease of the Breast. Cureus. 2017; 11: e1153. Ref.: https://goo.gl/SYfPYv
  35. El-Attrache B, Gluck B, Heimann A, Kapenhas E. A rarity in breast pathology: First recurrent male case of Rosai-Dorfman disease. Int J Surg Case Rep. 2018; 52: 137-139. Ref.: https://goo.gl/EWym1x
  36. Garces S, Medeiros LJ, Patel KP, Li S, Pina-Oviedo S, et al. Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease. Mod Pathol. 2017; 30: 1367-1377. Ref.: http://tinyurl.com/yxcysy7w
  37. Matter MS, Bihl M, Juskevicius D, Tzankov A. Is Rosai-Dorfman disease a reactive process? Detection of a MAP2K1 L115V mutation in a case of Rosai-Dorfman disease. Virchows Arch. 2017; 471: 545-547. Ref.: http://tinyurl.com/yxnjurdy