Vicky Ping Chen | Editor
Affilation: Hong Kong University of Science and Technology, USA
Chen obtained her PhD in Biology at the Hong Kong University of Science and Technology, and is currently working as a research fellow at Mayo Clinic, USA. She began her PhD Study in molecular neuroscience studying the cellular and molecular events leading to the formation of neuronal synapses during development and regeneration. Her findings revealed the biosynthesis process of acetylcholinesterase (AChE) which terminates impulse transmission by hydrolyzing the neurotransmitter acetylcholine in neuro-to-neuron synapses and at the neuromuscular junctions. Currently, Dr. Chen has been focused on an enzyme that is closely related AChE, known as butyrylcholinesterase (BChE), which is known serving no role beyond metabolizing drugs and bioactive esters in the diet. After it became recognized that BChE hydrolyzes a “hunger” hormone peptide, ghrelin, Dr. Chen pioneered in exploring the physiological roles of BChE in obesity and stress-related mental illnesses.
Enzyme molecules; Cholinesterases; Alzheimer’s disease; Multiple sclerosis; Myasthenia gravis