Ranitidine is a widely used drug in Europe and its intake is usually well tolerated. Hypersensitivity reactions due to ranitidine are uncommon. The immediate mild reactions type are the most prevalent. In some special cases a delayed type reaction such as contact dermatitis or severe reactions with systemic involvement have been reported.
In the present paper, a case report of a 78-year old patient who experienced a maculopapular eruption after 7 days of oral treatment with ranitidine is described. Patch tests were performed twice with ranitidine with positive results confirming the diagnosis. In order to discard a double sensitization and a possible cross-reactivity phenomenon, patch test was performed once with famotidine, with a negative result. This is the first maculopapular exanthema reported as type IV hypersensitivity reaction to ranitidine confirmed by patch testing.
Moreover, there are only two reported cases showing a double sensitization to ranitidine and to other H2-receptor antagonists by patch testing after a delayed reaction due to ranitidine, the other being H2-receptor antagonists involving cimetidine and nizatidine, not famotidine.
Lipoma arborescens is an exceptional condition comprised of frond-like excrescences of mature adipose tissue. The condition was originally described by Albert Hoffa in 1904 with characteristic morphology of macroscopic, villous, frond- like excrescences recapitulating a tree-like appearance, as denominated by the term “arborescens” .
Bee venom is a very rich and varied biochemical complex, which explains the multitude of its physiological effects as well as its medical indications. In dermatology, apart from psoriasis, few studies have been conducted concerning its interest and effectiveness; however the preliminary results remain so promising and encouraging. We present a clinical case illustrating the efficacy of bee venom in cutaneous varicosities, with a review of the literature of its main dermatological indications.
WHO defined leprosy elimination as reaching a prevalence < 1 case of leprosy per 10,000 inhabitants. Mali eliminated the disease since 2001 but in 2011, it recorded 226 new cases. This has a serious involvement in term of disease spreading. Therefore, we undertook a cross sectional study in Kenieba health district, still above the WHO recommended elimination threshold to better understand the disease epidemiology and its associated potential factors. The study took place from October 2013 to September 2014. All consenting villagers, living in one of the selected villages were included and clinically examined for leprosy signs.
A total of 8,457 participants were included in this cross-sectional survey. The median age was 14 varying 0 to 102 years. The sex ratio was equal to 0.92. Nine new leprosy cases corresponding to a new case detection rate of 10.64 per 10,000 population were diagnosed. Four of them were multibacillary leprosy and three were found positive to acid-fast bacilli. The estimated prevalence of leprosy was 24.83 per 10,000 population. Living in Kenieba city (RR = 0.97, CI = [0.95-0.99]), using a bicycle (RR = 0.96, CI = [0.93- 0.99]) or other vehicle as transportation mean to reach the health center (RR = 0.96, CI = [0.93-0.99]) were protective factors significantly associated with new leprosy cases. Other factors such as age, education status, gender, time to reach a health center were not associated with leprosy case. Six among the nine health workers questioned knew at least two clinical signs of leprosy, three, its therapeutic regimens and three claimed to have previously being trained in diagnosing the disease.
Despite leprosy elimination as a public health problem at the country level, it remains highly endemic in the health district of Kenieba.
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