Oncocytic papillary cystadenoma of right laryngeal ventricle

A case of oncocytic papillary cystadenoma in a 72-year old woman, a rare tumor of laryngeal seromucinous glands of unclear nature is presented. The patient had a history of chronic inﬂ ammation of laryngeal mucosa and both her age and tumor location were typical. The lesion was resected transorally without complications. Histological ﬁ ndings are shown in the present study. The controversial status of oncocytic papillary cystadenoma as either a true neoplasm or a combination of metaplastic and hyperplastic changes, its resemblance to Warthin’s tumor and optimal approach to treatment are discussed.


Introduction
Oncocytic papillary cystadenoma (OPC) of the larynx is a rare lesion of uncertain nature [1,2]. The 4 th edition of the WHO International Histological Classi ication of Tumors (IHCT) places it among laryngeal salivary gland tumors [3]. OPC usually occurs in patients in the sixth or seventh decade of life [3]. An association with a history of smoking is sometimes reported and both prolonged vocal stress and chronic in lammation have also been suggested as possible factors [1]. The lesion typically arises in the supraglottic region of larynx [3].

Case presentation
A 72-year-old woman developed a mass in her right laryngeal ventricle clinically diagnosed as a cyst. A range of blood tests and a chest radiograph were performed with unremarkable results. 15 months earlier the patient was diagnosed with chronic in lammation of laryngeal mucosa based on the biopsy of left laryngeal ventricle and histological indings.
The mass was removed through direct laryngoscopy under general anesthesia, Kleinsasser laryngoscope was utilized for the procedure. There were no complications and the patient was discharged the following day. Vocal cords movement and quality of the voice were excellent after the next 2 months following surgery.
The specimen was ixed in formalin, embedded in paraf in and then processed in a standard manner to perform histological slides stained with hematoxylin and eosin. Histologic examination revealed a well-de ined multilocular cystic mass with short papillary projections and amorphous contents. The cysts lacked an apparent capsule ( Figure 1). The lining consisted of columnar cells with abundant granular, eosinophilic cytoplasm, and bland predominantly cigar-shaped nuclei with inconspicuous nucleoli. The nuclei exhibited palisading along the lumen of the cysts and a second noncontinuous basal layer of cells could be observed ( Figure 2). Some variation of nuclear morphology and arrangement was present in the papillary projections ( Figure 3). Of note was the absence of lymphoid stroma which differentiates the lesion from Warthin's tumor (WT). The change was identi ied as oncocytic papillary cystadenoma.

Abstract
A case of oncocytic papillary cystadenoma in a 72-year old woman, a rare tumor of laryngeal seromucinous glands of unclear nature is presented. The patient had a history of chronic infl ammation of laryngeal mucosa and both her age and tumor location were typical. The lesion was resected transorally without complications. Histological fi ndings are shown in the present study. The controversial status of oncocytic papillary cystadenoma as either a true neoplasm or a combination of metaplastic and hyperplastic changes, its resemblance to Warthin's tumor and optimal approach to treatment are discussed. https://doi.org/10.29328/journal.acr.1001048

Discussion
Exact nature of oncocytic papillary cystadenoma is uncertain and the literature data is arguing for both benign neoplastic and a combination of metaplastic and hyperplastic origin [1]. International Histological Classi ication of Tumors simply classi ies it as a salivary gland tumor [3]. Yamase and Putman, described a whole spectrum of oncocytic lesions in the total laryngectomy specimen, from simple oncocytic metaplasia of seromucinous glands to solid oncocytoma-like masses [4]. This may point to OPC being a part of continuum of metaplastic/hyperplastic changes rather than true neoplasm. OPC does not appear to be precursory to malignancy [1,5]. Several cases of concurrent OPC and laryngeal carcinoma have been described, but the two conditions are believed to have arisen independently, most likely due to common risk factors [4][5][6].
In the presented case the patient was in the typical age and the location of the lesion was likewise typical. Although it was unknown if the patient had a history of chronic smoking or vocal stress, the chronic in lammation of ventricular mucosa could have been a factor in the development of the change. The characteristic structure of epithelial lining of the cysts strongly resembles that commonly found in Warthin's tumor. Unlike Warthin's tumor the lesion showed no lymphoid stroma. Indeed, Stenner, et al. de ine OPC as a WT without the lymphatic component [5]. WT has been however proven to be of monoclonal nature [7] as opposed to unclear status of OPC.
In our case the change was managed via transoral resection which appears to be a suf icient approach in majority of such lesions [1,2]. Where speci ied in literature, the most common tool for excision of OPC and similar changes was a CO 2 laser [1,7,8]. Cases with multiple lesions have also been described [4,5] and so follow-up is still recommended as there is a possibility of subclinical foci of OPC which may manifest later following the excision of the main mass.