Volume 1 Issue 1

2017-10-19 Research Article

Comparison of Cardiovascular Risks following Smoking Cessation Treatments Using Varenicline vs. NRT among Schizophrenic Smokers

Abstract

Background: Schizophrenic patients have a lot higher smoking rates when compared to people in the general population. A variety of pharmaceutical cessation aids are available, which include nicotine replacement therapy (NRT), Bupropion SR, and Varenicline. Our objective was to assess which cessation medication would have lower risks in developing risk factors of cardiovascular diseases.

Methods: A population-based retrospective cohort study was conducted using the General Electric (GE) electronic medical record database (1995-2011). The cohort consisted of patients with a diagnosis of schizophrenia or schizoaffective disorder (ICD-9 code 295.00-295.99) and who had newly initiated use of any smoking cessation medication. We excluded our cohort who (1) were not prescribed atypical antipsychotics and (2) already had diagnosis of diabetes, hyperlipidemia or hypertension prior to index date. Follow up period was from 12 weeks onwards index date up to one year. The hazard ratio of developing cardiovascular risks was assessed using Cox proportional hazards regression model after controlling for other covariates.

Results: A total of 580 patients were included in our cohort. Among those, nearly half (n=276, 47.59%) developed one or more criteria of the metabolic syndromes. We found that smokers who were prescribed NRT were less likely to develop metabolic syndromes as compared to those who were prescribed Varenicline.

Conclusions: Physicians are advised to carefully weigh the risks against the benefits before prescribing cessation medications since risks for metabolic syndromes were found to be very high. Healthcare providers should monitor patients’ lab data regularly as this minority population is under higher risks.

Abstract Read Full Article HTML DOI: 10.29328/journal.apmh.1001001 Cite this Article

Recent Articles

2020-07-27 Research Article

Health professional stress during COVID-19 pandemic

Fatiha Bennaoui*, Nadia Ei Idrissi Slitine and Fadl Mrabih Rabou Maoulainine

Abstract Read Full Article HTML

2020-05-11 Research Article

Role of community health fairs in providing health services, improving health of rural residents

Justine Jobman, Trina Aguirre*, Ann Koehler, Leeza Struwe and Wendy Wells

Abstract Read Full Article HTML

2020-04-27 Research Article

Staff experiences of the REFOCUS intervention to support recovery in mental health: A qualitative study nested within a cluster randomized controlled trial

E Clarke, M Leamy*, V Bird, M Janosik, H Jordan, C Le Boutillier, R Macpherson, G Riley, K Sanger, J Williams and M Slade

Abstract Read Full Article HTML DOI: 10.29328/journal.apmh.1001014 Citation