Annals of Advances in Chemistry

Research Article

Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti-Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems

Alireza Heidari* and Christopher Brown

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

*Address for Correspondence: Alireza Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA, Email: Scholar.Researcher.Scientist@gmail.com; Alireza.Heidari@calsu.us

Dates: Submitted: 06 October 2017; Approved: 14 October 2017; Published: 17 October 2017

How to cite this article: Fatahala SS. Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti-Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Ann Adv Chem. 2017; 1: 057-060.

Copyright: © 2017 Heidari A, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the current study, combinatorial therapeutic approaches to DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems were investigated.

Introduction

The birth of stereoselectivity probably dates back to 1890, when Emil Fischer recognized that the reaction of L-Arabinose (C5H10O5) with Hydrogen Cyanide (HCN) provided bout 66% of one of the two possible diastereomers, namely, L-Mannonoitrile [1-20]. In this way, asymmetric induction was discovered, and thus one of the corner stone of diastereoselective synthesis laid down. The stereochemistry of elimination reactions of secondary and tertiary alcohols are meaningful with respect to both regioselectivity and/or stereoselectivity (anti vs. syn) only when it is obtained under the conditions where primary products are produced with minimum secondary isomerization [21-40].

We believe that we have found just the right system which can shed more light on the mechanism for the dehydration and/or substitution reactions over heterogeneous catalyst Cadmium Oxide (CdO), homogenous Triphenylphosphine (Phosphorustriphenyl) in DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules (Figure 1) with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems [41-91]. Additionally, we have investigated the effect of temperature, pressure, Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2) on the structure, reactivity and selectivity of Cadmium Oxide (CdO). Quantum Chemical Calculations (QCC) are utilized to simulate the structure, spectra and transition state of Cadmium Oxide (CdO) with adsorbed homogenous Triphenylphosphine (Phosphorustriphenyl) on DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems.

Figure 1: Molecular structure of (a) Benzylpenicillin (Penicillin G), (b) Fluoxetine Hydrochloride (Prozac and Sarafem), (c) Propofol (Diprivan), (d) Acetylsalicylic Acid (ASA) (Aspirin), (e) Naproxen Sodium (Aleve and Naprosyn) and (f) Dextromethamphetamine nanocapsules [1-91].

Materials, Research Method and Experimental Techniques

Cadmium Oxide (CdO) is efficient catalysts for esterification reaction. Its success is based on the possibility to prepare it with strong Brønsted acidity and good resistance to high reaction temperatures. Moreover, Cadmium Oxide (CdO) has applications in different area of chemical industry such as cosmetics, artificial perfumes, flavours, pharmaceuticals, plasticizers, solvents, leather, painting and as the dehydrating agents.

A series of catalysts with varying Phosphoric acid (H3PO4) contents were prepared by impregnating calculated amounts of H3PO4 dissolved in Deionized water (DI water, DIW or de-ionized water) on Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2) supports. All the catalysts were characterized by Energy Dispersive X-Ray Analysis (EDXA), Energy Dispersive X-Ray Microanalysis (EDXMA), Scanning Electron Microscope (SEM), Brunauer-Emmett-Teller (BET) analysis, X-Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Differential Thermal Analysis-Thermal Gravim Analysis (DTA-TGA), Energy-Dispersive X-Ray Spectroscopy (EDX), 1HNMR, 13CNMR, 31PNMR, UV-Vis, HR-Mass, Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) and FT-Raman spectroscopies and Pyridine adsorption-desorption measurements. Then, the reaction of acetic acid with 1-butanol and 1-hexanol were carried out over these catalysts in vapour-phase. The effect of temperature from 200 to 400°C, the initial molar feed ratio, acid: alcohol molar ratio, the amount of loading H3PO4 over Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2), injecting rate of feed and the reaction time were also investigated. The optimized conditions for each alcohol were obtained and monitored by Gas Chromatography-Mass Spectrometry (GC-MS).

Optimized conditions of reaction were 0.1g of 45% H3PO4/Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2), T=584K, molar ratio (RCO2H:ROH) of 2:1 and for 1-hexanol and Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2), T=497K, molar ratio of 1:1, and for 1-butanol; time on stream of reaction was 23h. All the product esters showed selectivity close to 100%. From the studies on the esterification of acetic acid over Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2) and H3PO4/Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2) with different amounts of Triphenylphosphine (Phosphorustriphenyl) on DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems, the reaction shows higher conversion for 1-hexanol rather than1-butanol. The increase in the nanocapsules chain length of alcohol increases the hydrophobicity of alcohol, then the more hydrophobic alcohol will adsorb better to hydrophobic catalyst. H3PO4 increases hydrophobicity of Cadmium Oxide (CdO) and has a main effect on total conversion.

Results and Discussion

Catalytic hydrogenation is the most useful and widely applicable method for the reduction of chemical substances and belongs to the basic process of modern chemical industry. It has found numerous applications in the fuel industry, the synthesis of polymers and plastics, the food industry, the production of alcohols, carbonyl compounds and amines as well as in the manufacturing of fine chemicals, flavors and fragrances, agrochemicals and pharmaceuticals. Majority of industrial catalytic hydrogenations is still carried out using heterogeneous catalysts due to the process advantages such as stability, easy separation and wide range of applicable reaction conditions. The homogenous catalysts, which have been further developed during the past years, have extended the scope of catalytic hydrogenation especially in the field of highly stereoselective transformations. However, new developments continue to appear also in the field of heterogeneous catalysis, particularly in cases where a high chemo-, regio-, or stereoselectivity has to be achieved.

The selectivity aspects of catalytic hydrogenation over heterogeneous catalysts will be discussed and documented with several examples. All three types of selectivity (chemo-, regio- and stereoselectivity) will be addressed with special emphasis on the applicability of the catalytic procedure. The scope of chemoselective hydrogenation will be demonstrated by selective hydrogenation of unsaturated nitriles. It was found that the C≡N group can be hydrogenated prior to the C=C bond. Hydrogenation of Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules will represent an example of regioselective hydrogenation. In this case, only one of the two C=C bonds present in the molecule should be reduced to obtain desired product. Finally, an example will be given on stereoselective hydrogenation. One example will describe the diastereoselective hydrogenation applied in the DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems.

Conclusion

This study will deal with characteristic and historical aspects of heterogeneous catalysis, major challenges at present and ideas/prospective for the future. It will include the synthesis of major bulk and fine chemicals, of petrochemicals, the researchers in depollution and in biomass uses and its derived chemicals. Particular emphasis will be put on: (i) Activation and selective oxidation of Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules; (ii) Heterogeneous catalysis for fine chemicals; (iii) Asymmetric catalysis; (iv) Environment and biomass catalysis; (v) High throughput researches for combinatorial catalysis and (vi) Projection for catalysis in the last decade.

Case studies have been chosen to exemplify the different fields of interest. The case of Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules selective oxidation to the corresponding olefins or oxygenates will be presented such as the up-grading C1 to C5 nanocapsules, which is of paramount importance for fundamental and industrial interests, namely: how such inert nanocapsules rather cheap raw nanomaterials can be activated and up-graded. The case of Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules oxidation on basic catalysts based on Cadmium Oxide (CdO), Iron(III) Oxide (Fe2O3), Iridium(IV) Oxide (IrO2), Rhodium(III) Oxide (Rh2O3), Ruthenium(IV) Oxide (RuO2) and Titanium Dioxide (TiO2) were presented. A high combinatorial therapeutic approach for catalyst preparation was given. Environment catalysis for Selective Catalytic Reduction (SCR) Reaction was described. Finally, combinatorial therapeutic approaches to DNA/RNA of human cancer cells and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine nanocapsules with surface conjugated DNA/RNA of human cancer cells to targeted Nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using Nano drugs delivery systems were investigated.

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  63. Heidari A. Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology: Trends in Oncology Medicine and Practices. J Oncol Med & Pract. 2016; 1: 2.
  64. Heidari A. Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives. J Bioengineer & Biomedical Sci. 2016; 6: 3.
  65. Heidari A. X-Ray Fluorescence and X-Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design. J Powder Metall Min. 2017; 6: 1.
  66. Heidari A. Biomolecular Spectroscopy and Dynamics of Nano-Sized Molecules and Clusters as Cross-Linking-Induced Anti-Cancer and Immune-Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells Membranes under Synchrotron Radiations: A Payload-Based Perspective. Arch Chem Res. 2017; 1: 2. Ref.: https://goo.gl/57Zc6T
  67. Heidari A. Deficiencies in Repair of Double-Standard DNA/RNA-Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis. J Appl Bioinforma Comput Biol. 2017; 6: 1.
  68. Heidari A. Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing. Glob J Res Rev. 4: 2, 2017.
  69. Heidari A. Polymorphism in Nano-Sized Graphene Ligand-Induced Transformation of Au38-xAgx/xCux(SPh-tBu)24 to Au36-xAgx/xCux(SPh-tBu)24 (x=1-12) Nanomolecules for Synthesis of Au144-xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p-MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano Clusters as Anti-Cancer Nano Drugs. J Nanomater Mol Nanotechnol. 2017; 6: 3. Ref.: https://goo.gl/9XQEps
  70. Heidari A. “Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. Int J Biomed Data Min. 2017; 6: 103.
  71. Heidari A. Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for, Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation. J Dev Drugs. 2017; 6: 154.
  72. Heidari A. A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer's, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke. J Bioengineer & Biomedical Sci. 2017; 7: 127.
  73. Heidari A. Opinion on Computational Fluid Dynamics (CFD), Technique. Fluid Mech Open Acc. 2017; 4: 157.
  74. Heidari A. Concurrent Diagnosis of Oncology Influence Outcomes in Emergency General Surgery for Colorectal Cancer and Multiple Sclerosis (MS) Treatment Using Magnetic Resonance Imaging (MRI) and Au329(SR)84, Au329-xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 Nano Clusters”, J Surgery Emerg Med. 2017; 1: 1-21. Ref.: https://goo.gl/hfg7xe
  75. Heidari A. Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy). Cell Biol (Henderson, NV). 2017; 6: 1. Ref.: https://goo.gl/6X1jEY
  76. Heidari A. Changing Metal Powder Characteristics for Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins Adjustment in Cancer Metastases Induced by Osteosarcoma, Chondrosarcoma, Carcinoid, Carcinoma, Ewing’s Sarcoma, Fibrosarcoma and Secondary Hematopoietic Solid or Soft Tissue Tumors. J Powder Metall Min. 2017; 6: 170.
  77. Heidari A. Nanomedicine-Based Combination Anti-Cancer Therapy between Nucleic Acids and Anti-Cancer Nano Drugs in Covalent Nano Drugs Delivery Systems for Selective Imaging and Treatment of Human Brain Tumors Using Hyaluronic Acid, Alguronic Acid and Sodium Hyaluronate as Anti-Cancer Nano Drugs and Nucleic Acids Delivery under Synchrotron Radiation. Am J Drug Deliv. 2017; 5: 2. Ref.: https://goo.gl/PvNXPE
  78. Heidari A. Clinical Trials of Dendritic Cell Therapies for Cancer Exposing Vulnerabilities in Human Cancer Cells Metabolism and Metabolomics: New Discoveries, Unique Features Inform New Therapeutic Opportunities, Biotech's Bumpy Road to the Market and Elucidating the Biochemical Programs that Support Cancer Initiation and Progression. J Biol Med Science. 2017; 1: 103.
  79. Heidari A. \The Design Graphene-Based Nanosheets as a New Nanomaterial in Anti-Cancer Therapy and Delivery of Chemotherapeutics and Biological Nano Drugs for Liposomal Anti-Cancer Nano Drugs and Gene Delivery. Br Biomed Bull. 2017; 5: 305. Ref.: https://goo.gl/Gop23g
  80. Heidari A. Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation. Transcriptomics. 2017; 5: 117.
  81. Heidari A. Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation. Lett Health Biol Sci. 2017; 2: 1-4.
  82. Heidari A. Treatment of Breast Cancer Brain Metastases through a Targeted Nanomolecule Drug Delivery System Based on Dopamine Functionalized Multi-Wall Carbon Nanotubes (MWCNTs) Coated with Nano Graphene Oxide (GO) and Protonated Polyaniline (PANI) in Situ During the Polymerization of Aniline Autogenic Nanoparticles for the Delivery of Anti-Cancer Nano Drugs under Synchrotron Radiation. Br J Res. 2017; 4: 16.
  83. Heidari A. Sedative, Analgesic and Ultrasound-Mediated Gastrointestinal Nano Drugs Delivery for Gastrointestinal Endoscopic Procedure, Nano Drug-Induced Gastrointestinal Disorders and Nano Drug Treatment of Gastric Acidity. Res Rep Gastroenterol. 2017; 1: 1.
  84. Heidari A. Synthesis, Pharmacokinetics Pharmacodynamics, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat, High Cholesterol and Related Conditions and to Prevent, Cardiovascular Disease under Synchrotron Radiation. J Pharm Sci Emerg Drugs. 2017; 5: 1.
  85. Heidari A. Non-Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams”, J Cell Biol Mol Sci. 2017; 2: 1-5.
  86. Heidari A. Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood-Brain Barrier (BBB) Translocation to Targeted Deliver Anti-Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation. J Nanotechnol Material Sci. 2017; 4: 1-5.
  87. Gobato R, Heidari A. Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi. American Journal of Quantum Chemistry and Molecular Spectroscopy. 2017; 2: 37-46. Ref.: https://goo.gl/mNceSB
  88. Heidari A. An Investigation of the Role of DNA as Molecular Computers: A Computational Study on the Hamiltonian Path Problem. International Journal of Scientific & Engineering Research. 2014; 5: 1884-1889. Ref.: https://goo.gl/33Tn6p
  89. Heidari A. Different High-Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti-Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X-Ray Radiations. J Med Oncol. 2017: 1.
  90. Heidari A. A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation. Am J Ethnomed. 2017; 4: 10.
  91. Heidari A. Active Targeted Nanoparticles for Anti-Cancer Nano Drugs Delivery across the Blood-Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti-Cancer Nano Drugs or Drug-Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. J Med Chem Toxicol. 2017; 2: 1-5