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Volume 1 Issue 1

  • article icon
    Research Article
    Published: 09/25/2017 | Pages: 1(1): 075-091

    The master regulator gene PRDM2 controls C2C12 myoblasts proliferation and Differentiation switch and PRDM4 and PRDM10 expression

    Di Zazzo Erika#, Bartollino Silvia*# and Moncharmont Bruno

    The Positive Regulatory Domain (PRDM) protein family gene is involved in a spectrum variety of biological processes, including proliferation, differentiation and apoptosis: its member seem to be transcriptional regulators highly cell type and tissue peculiar, towards histones modifications or recruitment of specificinteraction patters to modify the expression of target genes.

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    Review Article
    Published: 08/31/2017 | Pages: 1(1): 045-074

    Use of MicroRNAs to Screen for Colon Cancer

    Farid E Ahmed*, Nancy C Ahmed, Mostafa Gouda and Chris Bonnerup

    Colon cancer (CC) screening is important for diagnosing early stage for malignancy and therefore potentially reduces mortality from this disease because the cancer could be cured at the early disease stage. Early detection is needed if accurate and cost effective diagnostic methods are available. Mortality from colon cancer is theoretically preventable through screening.

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    Review Article
    Published: 08/25/2017 | Pages: 1(1): 039-044

    Surface Plasmon Resonance technology to assess biological interactions

    Silvia Bartollino*, Alessandro Medoro, Donatella Mignogna, Erika di Zazzo and Bruno Moncharmont

    Molecular interactions between proteins or between proteins and small molecules are pivotal events for selective binding of biological structures and, consequentially, for their correct function. In this scenario, the evaluation of kinetic parameters, characterizing a molecular interactions, is considered a crucial event to reveal the nature of binding processes.

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    Review Article
    Published: 07/25/2017 | Pages: 1(1): 026-038

    Transglutaminase inhibition: possible therapeutic mechanisms to protect cells from death in neurological disorders

    Rosaria Romano, Nicola Gaetano Gatta, Elenamaria Fioretti and Vittorio Gentile*

    Transglutaminases are a family of Ca2+-dependent enzymes which catalyze post-translational modifi cations of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition to lysyl residues, other second nucleophilic co-substrates may include monoamines or polyamines (to form mono-or bi-substituted/ crosslinked adducts) or -OH groups (to form ester linkages).

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    Mini Review
    Published: 06/06/2017 | Pages: 1(1): 016-025

    Fungi present in home and their impact on human health-A short review

    Mariusz DylÄ…g*

    It is estimated that even up to 30% of buildings worldwide may be the subject of complaints connected with the quality of indoor air. Potential sources of air pollution can be both organic and inorganic particles. This article focuses on biological air pollutants from living and dead biological sources, especially those connected with fungi. Fungi found in the indoor air of domestic dwellings in a large extent are similar in their species composition to those found on the outside of the building.

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    Research Article
    Published: 01/20/2017 | Pages: 1(1): 009-015

    Ethical Dimensions of Population Genetic Research in the Caucasus

    Ramaz Shengelia* and Theodore G Schurr

    The emergence and establishment of anthropological genetics as an interdisciplinary science is primarily, associated with the development of new genomic technologies. Precision genetic testing on the one hand, and the rapidly increasing number of genetic investigations on the other, have created a set of bioethical dilemmas for genetic and epidemiology research. Such research deals with persons who have the right to the protection of their personal information and confidentiality, and also concerns collective (village, region, ethnic group, state) consciousness, ethnic identity, and traditional culture, i.e., so called “ethnic pride”.

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    Short Review
    Published: 01/09/2017 | Pages: 1(1): 001-008

    Endothelial Repair and Endothelial Cell-Derived Secretome

    Alexander E. Berezin*

    Growing evidence supports the hypothesis that endothelial cell-derived microparticles (MPs) might contribute to the pathogenesis of cardiovascular (CV) disease. Endothelial cell-derived MPs play a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity and metabolic memory phenomenon. There is evidence that the MPs are secreted actively accompanied to other regulatory molecules.

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