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Volume 1 Issue 1

  • article icon
    Research Article
    Published: 11/15/2017 | Pages: 1(1): 067-100

    Pros and Cons Controversy on Molecular Imaging and Dynamics of Double- Standard DNA/RNA of Human Preserving Stem Cells-Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium-4 Nucleus (Alpha Particle) Using Synchrotron Radiation

    Alireza Heidari*

    In the current study, we have investigated pros and cons controversy on molecular imaging and dynamics of double-standard DNA/RNA of human preserving stem cells-binding......

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    Research Article
    Published: 08/31/2017 | Pages: 1(1): 061-066

    Nutritional Value of Three Different Oyster Mushrooms Grown on Cattail Weed Substrate

    Ram Naraian* and Bharti Dixit

    Three distinct oyster mushroom strains including Pleurotus florida (PF), Pleurotus eous (PE) and Pleurotus sajor-caju (PS) were successfully cultivated on cattail weed substrate. A comparative analysis of different parameters viz., biological efficiency (BE) and protein, carbohydrate, crude fiber and fat content in fruitbodies were evaluated.

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    Review Article
    Published: 07/17/2017 | Pages: 1(1): 054-060

    Is advanced Coupling Methods best fitted in Biosensing of Microparticles?

    Alexander E Berezin*

    Microparticles (MPs) are considered important diagnostic biological markers in many diseases with promising predictive value. There are several methods that currently used for the detection of number and characterization of structure and features of MPs. Therefore, the MP detection methods have been remained pretty costly and time consuming.

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    Review Article
    Published: 06/28/2017 | Pages: 1(1): 033-053

    Concise Review: Considerations for the Formulation, Delivery and Administration Routes of Biopharmaceuticals

    Amir Mohammed Alsharabasy*

    The drugs of biological origins have attracted the attention of many pharmaceutical companies where it is essential to protect the heterogeneous nature and the optimal three dimensional structures of the different macromolecules. These molecules are used in both the investigation and therapy purposes, so their maximum activities should be maintained.

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    Review Article
    Published: 05/01/2017 | Pages: 1(1): 021-032

    The Bacterial Heterotrimeric Amidotransferase GatCAB: functions, structures and mechanism-based inhibitors

    Van Hau Pham* and Jacques Lapointe

    tRNA-dependent amidotransferases (AdT) are essential enzymes for protein biosynthesis in many bacteria and in all archaea. As AdT is essential for a number of pathogenic bacteria, and it is absent from mammalian cytoplasm, it is considered as a putative target for novel inhibitors that could be lead compounds to develop a new class of antibiotics. Besides GatFAB of Saccharomyces cerevisiae mitochondria and GatAB of Plasmodium falciparum apicoplast, all reported AdT can be divided into two groups: heterodimeric GatDE and heterotrimeric GatCAB. The latter is required to catalyze the conversion of Glu-tRNAGln and/or Asp-tRNAAsn into Gln-tRNAGln and/or Asn-tRNAAsn in many pathogenic bacteria. Recently determined high resolution crystal structures of several GatCAB could be used to design new inhibitors. 

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    Letter to the Editor
    Published: 05/01/2017 | Pages: 1(1): 017-020

    The Daring of Biosimilars

    Nuris Ledón* and Agustín Lage

    The so-called “biotechnological revolution” is changing the structure of the Pharmacopoeia [1]. The space of biological products, previously limited to blood products and vaccines, grew from the introduction of first recombinant therapeutics in the 1980s until attaining a 25% by value of the pharmaceutical market. This share is expected to reach 50% in the coming years. More than 80 biotechnology drugs have entered the market in the last ten years. It is estimated that there are more than 900 biological products on development for more than 100 diseases [2].

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    Review Article
    Published: 04/25/2017 | Pages: 1(1): 001-016

    Overview of Interferon: Characteristics, signaling and anticancer effect

    Huaiyuan Wang, Haijun Hu and Kangjian Zhang*

    Interferons are multifunctional cytokines widely used in clinical settings as an anti-viral drug. In addition, interferon’s exhibit anti-cancer and anti-bacterial effects. Nearly two thousand papers related to interferon are published each year, which illustrates the importance placed by researchers on the study of interferon. This review focuses on recent advances in the study of interferon, particularly in the areas of its mechanism of anti-cancer effect and signal transduction. We also describe the tumor resistance to interferon and the side-effect of interferon-based therapy, which leads to an expectation of future research of interferon.

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