The benefits of biochemical bone markers

1. Menopaused female group: there has been fast reducing rate of bone density than normal. Though bone tissue grows, it isn’t so much as its reducing rate. It results in rate 3% 5% decreasing of bone density per year. Gradually, the rate goes on; however, the females of that age don’t lose much of it. Years later, they will ind a big loss rate of bone density. How do we measure the loss rate of bone resorption and bone formation for those female group? Blood test for BMK is needed for accurate treatment planning.


To improve ef iciency in Osteoporosis treatment
2. To adjust the dosage of medication for osteoporosis with BMK 3. To adjust bone life cycle as needed 4. To prevent bone necrosis which dentists have been worried.

To reduce cost of treatment
BMK test population 1. Menopaused female group: there has been fast reducing rate of bone density than normal. Though bone tissue grows, it isn't so much as its reducing rate. It results in rate 3% -5% decreasing of bone density per year. Gradually, the rate goes on; however, the females of that age don't lose much of it. Years later, they will ind a big loss rate of bone density. How do we measure the loss rate of bone resorption and bone formation for those female group? Blood test for BMK is needed for accurate treatment planning.

Senior group:
If BMD and BMK have never been tested. Patients will be given Osteoporosis treatment, both bone antiresorpting and bone formatting drugs. However, many patients found low resorpting rate of bone through BMK blood test, and if antiresorptive drug is prescribed, the rate of resorption will be much lower.
Vice versa, while people at 80s with no sign of any bone balance adjustment still have high bone resorpting rate, they need its antiresorptive treatment, and BMK blood test is needed from time to time to measure the patients adjustment and when lower rate of bone resorption to 70% -100% they can stop bone antiresorptive drug. In some cases, an automatic increase of bone resorption may show when they need BMK blood tests from time to time. b. Low rate on both which means long life cycle with little bone loss and little bone formation. The condition won't change but bone quality is poor which is not good.

Group of chronic illness:
2. Compairing the rates of bone resorption and bone formation.
a. If resorption is more than formation, the condition gradually becomes Osteoporosis.
b. If resorption is less than formation, the condition may be from other diseases.
3. Measuring the result of treatment by BMK, compairing between PINP and CTx or Betacrosslops numbers, if the result between bone formation and bone resorption is less than  10% difference, considering the result is in balance.
There has been long use of Bisphosphonates for bone antiresorption; for example, Alendronate 3. Normal NMID represents for Osteocalcin resorption = 15.

How to convert the value of BMK into percentage
Results of BMK test alone cannot answers many questions. The ideas to clear these answers are very simple by converting the result into percentage.
The way of converting the BMK results in to percentage is followed.

One month after the treatment
1. Bone formation is more than bone resorption = 97% -93% = 4% which is in balance.
The use of BMK to adjust the dose of Bisphosphonates for the treatment of osteoporosis [2] From the study of BMK blood test result to evaluate osteoporosis treatment especially for bone resorption control among 708 patients within 12 years (2005 -2017), 480 patients have taken Bisphosphonates [5]. The result has turn out, astonishingly, opponent for patients, costing a lot as well even though both doctors and patients have been con ident treatment was in the right direction. Consequently, there is in depth analysis of 480 patients using Bisphosphonates as shown in the followings.
Result of one month administration of Bisphosphonates [3] One month course of all bisphosphonates have so effective:- No matter which medicines given in a month according to the manufacture, similar results will come out. When stopping the use of those medicines, it will take 3-4 months to resume CTx to 70% -100%. The results for all medicines are similar. Effectiveness length of time of medicine prescription for each patient can be different depending on patient's conditions whether to resist or accept dosage, their illness conditions, their other treatments, as well as fruits they eat. We can see that all mentions including some herbs or supplements will affect CTx, increasing 100+% of which data has been collected. So, Bisphosphonate given to patients for years can turn out disadvantages due to low rate of bone resorption and high cost of treatment until they require long time to resume to normal. Especially for those 2 patients who had no recovery at all.
It is important to control CTx value in 70% -100% besides what was mentioned in 1, Bone life cycle range is considered safe. If CTx is higher than 100%, bone resorption will be more than normal, or bone age will be shorter. Micro fracture can easily happen. It can remarkably decrease bone structure, causing bone fractures more easily. Therefore, CTx or Bone resorpting needs to be 70% -100%, and if this is controlled, a little longer bone life cycle means Micro fracture prevention.

How many BMK test should be done
Blood test for BMK is needed before treatment, then is compared to that of post-one month treatment so that 1. Bone antiresorption a dosage is appropriate, considering CTx or Betacrosslaps, for example.
If pretreatment CTx = 0.625% or 201% One month posttreatment CTx = 0.26% or 83% It shows that treatment dosage is appropriate and bone antiresorption dosage can be the same.
If before treatment CTx = 0.625% or 201% and after treatment = 0.12% or 38%, it shows too much dosage of bone antiresorption which needs to be adjusted; 1 tablet per month change to 1 tablet per 2 months, or 1 tablet a week change to 1 tablet per 2 weeks or 1 tablet a day change to 1 tablet per 2 days. After adjustment for a month have another BMK blood test until getting value of 0.22% -0.31% or 70% -100% so that period of bone antiresorpting tablet effectiveness (months, weeks or days) till be measured after that 2 -3 BMK tests adjustment be performed for sure of accurate dosage. On the other hand, if bone formation is more than Bone resorption, there will be urinary stones or calcium deposit in aorta, or in aortic valve, and extra osseous calci ication.

Bone formation adjustment
In case that both CTx and PINP values need to be adjusted CTx should be done irst until CTx is in between 70% -100%, and at that point if PINP is not in balance, then PINP would be adjusted later.

Result of Osteoporosis treatment by measuring BMD change via BMK blood test [5]
127 patients used BMK to control the treatment in 2 years. For this patient, osteoporosis treatment dosage has been adjusted by Biochemical Bone Maker for 2 years showing better direction change of BMD value. Also, Bone life cycle has been a little longer than normal. Moreover, it is important that balance of Bone formation and Bone resorption is in control.