Research Article

Drug abuse and its ramifications on skeletal system

Das Sanjita* and Kumar Naveen

Published: 11/05/2019 | Volume 2 - Issue 1 | Pages: 083-086


The purpose of this study is to highlight the drug abuse hazards and preventive aspects. From a public health perspective, substance abuse has long been a source of major concern, both for the individual’s health and for wider society as a whole. The UK has the highest rates of recorded illegal drug misuse in the western world. In particular, it has comparatively high rates of heroin and crack cocaine use. Substances that are considered harmful are strictly regulated according to a classification system that takes into account the harms and risks of taking each drug. The adverse effects of drug abuse can be thought of in three parts that together determine the overall harm in taking it. Some addictive substances are more damaging to the skeletal system along with the others. In this review article, an effort has been taken to elaborate the effects of addictive drugs on human highlighting these most problematic substances for bones and also the promising potential prevention aspects of drug abuse.

Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001008 Cite this Article


  1. Nutt D, King LA, Saulsbury W, Blakemore C. Development of a rational scale to assess the harm of drugs of potential misuse. The Lancet. 2007; 369: 1047-1053. PubMed:
  2.  Mosby's Medical, Nursing & Allied Health Dictionary. Drug abuse definition. 2002; 552.
  3. Fonseca F, Gilchrist G, Torrens M. Integrating addiction and mental health networks to improve access to treatment for people with alcohol and drug-related problems: A qualitative study. Adv Dual Diagn. 2012; 5: 5-14.
  4. National Institute on Drug Abuse (NIDA). NIH. NIDA Info Facts. 2019.
  5. Weber JE, Larkin GL, Boe CT, Fras A, Kalaria AS, et al. Effect of cocaine use on bone marrow-mediated erythropoiesis. Acad Emerg Med. 2003; 10: 705-708. PubMed:
  6.  Gozashti MH, Shahesmaeili A, Amini Zadeh Iran N. Is Opium Addiction a Risk Factor for Bone Loss? Red Crescent Med J. 2011; 13: 464-468.
  7. Pedrazzoni M, Vescovi PP, Maninetti L, Michelini M, Zaniboni G, et al. Effects of chronic heroin abuse on bone and mineral metabolism. Acta Endocrinol (Copenh). 1993; 129: 42-45. PubMed:
  8. Chang G, Antin JH, Orav EJ, Randall U, McGarigle C, et al. Substance abuse and bone marrow transplant. Am J Drug Alcohol Abuse. 1997; 23: 301-308. PubMed:
  9. Wilkinson ST, Radhakrishnan R, D'Souza DC. Impact of Cannabis Use on the Development of Psychotic Disorders. Curr Addict Rep. 2014; 1: 115-128. PubMed:
  10. Stall R, Paul JP, Greenwood G, Pollack LM, Bein E, et al. Alcohol use, drug use and alcohol-related problems among men who have sex with men: the Urban Men's Health Study. Addiction. 2001; 96: 1589-1601. PubMed:
  11. Balster RL. Inhalant abuse, a forgotten drug abuse problem; College on Problems of Drug Dependence Presidential Address. 1996.
  12. Rafaiee R, Ahmadiankia N. Bone Marrow Derived Mesenchymal Stem Cells in Addiction Related Hippocampal Damages. Int J Mol Cell Med. 2018; 7: 70-79. PubMed:
  13. Ellingboe J, Mendelson JH, Kuehnle JC. Effect of heroin naltrexone on plasma prolactin levels in man. Pharmacol Biochem Behav. 1980; 12: 163-165. PubMed: