Introduction

Bone marrow is the soft spongy tissue that lies within the hollow interior of long bones. In adults, marrow in large bones produces new blood cells. Bone marrow forms around 4% of total body weight. There are two types of bone marrow: red marrow that is responsible for producing red blood cells, white blood cells and platelets; and yellow marrow consisting mainly of fat cells.

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Recent Articles

2020-05-04 Review Article

The benefits of biochemical bone markers

Sek Aksaranugraha*

To improve efficiency in Osteoporosis treatment
To adjust the dosage of medication for osteoporosis with BMK
To adjust bone life cycle as needed
To prevent bone necrosis which dentists have been worried.
To reduce cost of treatment

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001013 Cite this Article

2020-04-13 Research Article

The alterations effects in phosphorus of erythropoietin and U-74389G

C Τsompos, C Panoulis, A Triantafyllou, CG Zografos, K Tsarea, M Karamperi and A Papalois

Abstract

Aim: This study calculated the effects on serum phosphorus (P) levels, after treatment with either of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001012 Cite this Article

2020-04-03 Review Article

Novel European Asiatic Clinical, Laboratory, Molecular and Pathobiological (2015-2020 CLMP) criteria for JAK2V617F trilinear polycythemia vera (PV), JAK2exon12 PV and JAK2V617F, CALR and MPL515 thrombocythemias: From Dameshek to Constantinescu-Vainchenker, Kralovics and Michiels

Jan Jacques Michiels*, King H Lam, Fibo Ten Kate, Dong-Wook Kim, Myungshin Kim, Vasily Shuvaev, Francisca Valster, Vincent Potters, Wilfried Schroyens, Mihaela Andreescu, Adrian Trifa, Achille Pich and Hendrik De Raeve

Abstract

The Myeloproliferative Neoplasms (MPN) of trilinear polycythemia vera (PV) and megakaryocytic leukemia (ML = primary megakaryocytic granulocytic myeloproliferation: PMGM) and Essential Thrombocythemia (ET) in the studies of Dameshek and Michiels are caused by the MPN driver m...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001011 Cite this Article

2019-12-05 Research Article

The motivational factors and adverse events experienced by healthy volunteers donating bone marrow for research

Mirella Ejiugwo, Georgina Shaw, Frank Barry, Janusz Krawczyk and Veronica McInerney*

Abstract

Background: With the advancement of cell therapy research, there is an increasing need for healthy volunteers (HV) to donate small volumes (30 ml) of human bone marrow (BM). The BM procedure required to procure small volumes is invasive, although short-lived ...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001010 Cite this Article

2019-11-11 Research Article

Correlation of plasma protein from MDS, young and elderly patients by SDS-page

Nathanielly de Lima Silva, Danilo Nobre, Josiel Nascimento dos Santos, Márcia Santos Rezende, Lúcio Henrique Sousa Pinheiro, Carlos Arthur Cardoso Almeida and Dulce Marta Schimieguel*

Abstract

Summary: Myelodysplastic Syndrome (MDS) is a heterogeneous group of clonal hematopoietic malignancies characterized by progressive cytopenias, ineffective hematopoiesis, bone marrow hypercellularity and transformation to acute myeloid leukemia (AML).

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Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001009 Cite this Article

2019-11-05 Review Article

Drug abuse and its ramifications on skeletal system

Das Sanjita* and Kumar Naveen

Abstract

The purpose of this study is to highlight the drug abuse hazards and preventive aspects. From a public health perspective, substance abuse has long been a source of major concern, both for the individual’s health and for wider society as a whole. The UK has the highest ...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001008 Cite this Article

2019-08-16 Letter to the Editor

Serum MicroRNA-155 in Acute Graft-Versus-Host-Disease (aGVHD)

Yvonne A Efebera*, Amy S Ruppert, Apollinaire Ngankeu, Sabrina Garman, Prasanthi Kumchala, Alan Howard, Steven M Devine, Parvathi Ranganathan and Ramiro Garzon

Letter to Editor

Allogeneic hematopoietic stem cell transplant (alloHSCT) is a curative treatment for many hematologic malignancies. Unfortunately, about  30-50% of all recipients undergoing alloHSCT develop acute graft-versus-host-disease (aGVHD), which is associated with high m...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001007 Cite this Article

2019-06-21 Research Article

Bone marrow histology in CALR mutated thrombocythemia and myelofi brosis: results from two cross sectional studies in 70 newly diagnosed JAK2/MPL wild type thrombocythemia patients

Jan Jacques Michiels*, Yonggoo Kim, Myungshin Kim, Francisca Valster, Vincent Potters, Zwi Berneman, Alain Gadisseur, Wilfried Schroyens and Hendrik De Raeve

Abstract

The clinical phenotypes in 268 JAK2V617F mutated MPN patients in the Seoul study were PV in 101, ET in 95 and MF in 78 and 56 CALR mutated MPN consisted of PV in none, ET in 40 and MF in 16 cases. CALR mutated MPN patients were younger than JAK2V617F mutated MPN patients (mea...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001006 Cite this Article

2019-05-13 Case Report

The forgotten player in the surgical history

Yves Cirotteau*

Abstract

The research concerning a preventive treatment of an osteoporitic femoral neck fracture started in 1990 because the surgical procedure of unstable femoral neck fractures is difficult. After effects are frequent and their number will increase in the next decade. The goal is to...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001005 Cite this Article

2019-04-17 Research Article

The PVSG/WHO versus the Rotterdam European clinical, molecular and pathological diagnostic criteria for the classification of myeloproliferative disorders and myeloproliferative neoplasms (MPD/MPN): From Dameshek to Georgii, Vainchenker and Michiels 1950-2018

Jan Jacques Michiels* and Hendrik De Raeve

Abstract

The present article extends the PVSG-WHO criteria into a simplified set of Rotterdam and European Clinical, Molecular and Pathological (RCP/ECMP) criteria to diagnose and classify the myeloproliferative neoplasms (MPNs). The crude WHO criteria still miss the masked and early ...

Abstract Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001004 Cite this Article