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Volume 1 Issue 1

  • article icon
    Research Article
    Published: 10/30/2017 | Pages: 1(1): 086-093

    Cytokine Modulatory Effects of Sesamum Indicum Seeds Oil Ameliorate Mice with Experimental Autoimmune Encephalomyelitis

    Mohammad Reza Javan*, Mohammad Reza Zamani, Saeed Aslani, Ghader Dargahi Abbasabad, Masoud Beirami Khalaj and Hamed Serati-Nour

    Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nerve system (CNS), which affects the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is the most commonly applied experimental model for studying the MS. The aim of this study was to determine the effects of Sesamum indicum seeds oil on Experimental Autoimmune Encephalomyelitis (EAE) in mice.

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  • article icon
    Review Article
    Published: 10/23/2017 | Pages: 1(1): 061-085

    Lack of applicability of the Enterocyte Chloride ion secretion paradigm to the Pathology of Cystic Fibrosis

    Michael L Lucas*

    This review examines of the concept of a defective chloride channel in epithelial cells being a major cause of cystic fibrotic pathophysiology. The central concept of the defective chloride ion channel paradigm is that
    faulty CFTR protein or failed delivery of CFTR protein to the mucosal membrane of epithelial cells is the basis of cystic fibrosis.

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  • article icon
    Mini Review
    Published: 09/20/2017 | Pages: 1(1): 040-060

    The use of Allergoids and Adjuvants in Allergen Immunotherapy

    Celso Eduardo Olivier*

    Allergen immunotherapy (AIT) is the unique curative treatment to help allergic patients to get over their allergies. With a personalized approach, AIT is the best example of precision medicine.

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    Case Report
    Published: 08/23/2017 | Pages: 1(1): 036-039

    Inducible Laryngeal Obstruction/ Vocal Cord Dysfunction and the Role It Plays in Refractory Asthma

    Jorge Villalpando, Jay I Peters* and Sandra G Adams

    Chronic asthma accounts for a significant amount of unscheduled office and emergency department (ED) visits. According to the latest World Health Organization statistics, asthma worldwide affects 300 million individuals and creates a substantial health burden by restricting the patient’s lifetime activities. Data estimate that asthma causes a loss of disability-adjusted life years over 150,000/year [1].

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  • article icon
    Research Article
    Published: 08/22/2017 | Pages: 1(1): 028-035

    Prevalence of reported drug allergy and its impact on Beta lactam use with fi nancial and health implications

    Abirami Murugesh-Warren#, Ranu Malhi#, Yogini Jani, Christopher Corrigan, David Walker, Harsha Kariyawasam and Joanna Lukawska*

    Background: While recognition and documentation of true drug allergy is critically important, most physicians acknowledge that its prevalence is likely overestimated, often on the basis of historical, sometimes anecdotal evidence. Correct or not, once applied, drug allergy labels may result in altered, potentially inferior therapy, increased costs and prolonged hospitalisation.

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  • article icon
    Review Article
    Published: 07/10/2017 | Pages: 1(1): 015-027

    The effects of early low dose exposures to the Environmental Estrogen Bisphenol A on the Development of Childhood Asthma

    Terumi Midoro-Horiuti* and Randall M Goldblum

    Exposure to environmental chemicals is a potential cause for the rapid increase in the prevalence of allergic asthma over the last few decades. The production of the environmental estrogen bisphenol A, the monomer of polycarbonate plastics, has increased rapidly over the last 50 years, such that bisphenol A is one of the most highly produced chemicals.

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    Research Article
    Published: 05/29/2017 | Pages: 1(1): 009-014

    Features of Interferon and Cytokine Status in Atopic Dermatitis

    Ospelnikova TP*, Gevorkyan OV, Mironova TV, Andreeva SA, Kolodyazhnaya LV and Ershov FI

    The insuffi ciency of interferon production and the cytokine imbalance in patients with atopic dermatitis, especially in combination with persistent herpes virus infection, has been identified. The expediency of the use of interferon inducer Cycloferon in the treatment of chronic atopic dermatitis has been shown.

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    Case Report
    Published: 01/31/2017 | Pages: 1(1): 001-008

    Atopic Conjunctivitis in Children: Influence of Treatment with Topical Cyclosporin 0.05% in the Quality of Life

    Carlos Alberto Sanchez Salguero and Alvaro Isidro Sanchez Chacon

    Introduction: Forty-six per cent children have allergic rhinoconjunctivitis (Allergologica 2005).
    Working hypothesis: Ocular topical cyclosporine improves the quality of life for these patients.
    Material, methods, design: 2-year prospective study (2015-16), 40 patients with topical corticosteroids without improvement, followed 20 and 20 switched to corticosteroids cyclosporine 0.05%. Interview with Quality of Life Questionnaire in Children with rhinoconjunctivitis (PRQLQ) before and at the end of treatment. Mean age of 10.3 years with 60% male-40% female. Treatments were applied from January to March. There were 15 questions divided into two blocks. Children responded using a card with responses rated from zero (not bothered at all) to 6 (quite upset).

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