Thaiz Ferraz Borin
Affilation: Augusta University, USA
Journal Associated: Journal of Genetic Medicine and Gene Therapy
I had a bachelor degree of Science in Nursing in 2002. In 2003 I started my graduation and finished my PhD in 2008 in the most important institute of heart diseases in Latin America, Instituto do Coracao (InCor) at University of Sao Paulo (USP). As a young scientist, I studied the effect of increased IL-1β during vein grafts arterialization using ex vivo, in vitro and in vivo models. I demonstrated that the model of arterialization of the venous segment in rat model reproduces several of the morphological changes described in the human's venous graft disease and thus useful in the characterization of candidate genes involved in this process.Following my PhD, I had a 4 years’ experience in clinical field working as a nurse in an ambulatory care at the Public Health and as an Intensive Cardiologic Care Unit. I also worked as a Lecturer and Coordinator of the Undergraduate Nursing program and taught undergraduate classes for Nurses and Physical Educators. Following this important undertaking into clinical and academic areas I started my post-doctoral fellowship in 2012. As a postdoctoral fellow I was trained at Henry Ford Hospital (Detroit/MI), FAMERP (Sao Paulo/Brazil) and Georgia Cancer Center (Augusta/GA) to carry out animal studies involving metastasis models, tumor microenvironment, SPECT/CT images analysis, microRNA silencing, anti-metastatic treatments, vascular mimicry, angiogenesis, etc. In my capacity as a Postdoctoral Fellow, I have gained considerable experience in treatment approaches like inhibition of VEGF-VEGFR and ROCK-1 pathway through HET0016 and Melatonin in triple negative breast cancer metastasis. I have expertise in cell biology, gene edition, shRNA and miRNA silencing therapy, exosome isolation and characterization, tumor model preparation, flow cytometry, immunochemistry and gained profound knowledge troubleshooting in these areas. I have gathered valuable experience in animal handling, data collection, and analysis and manuscript writings. Currently, I am an Assistant Research Scientist in the Tumor Angiogenesis Laboratory, Georgia Cancer Center, Augusta University, Augusta, GA. I have a profound interest in understanding the dynamic interplay of the Breast cancer and its tumor microenvironment, angiogenesis, vasculogenesis, and metastasis hallmarks in tumor growth and invasion.
Breast cancer; metastasis; glioblastoma; Arachidonic acid pathway; melatonin;