Affilation: Instituto Venezolano de Investigaciones CientÃficas, Venezuela
Journal Associated: Archives of Biotechnology and Biomedicine
Dr. Mercedes Lopez is currently working as a Head of Hemostasis and vascular genetic laboratory at the Instituto Venezolano de Investigaciones Cientificas (IVIC), the most recognized research institute in Venezuela. She graduated from the Catholic University “Andrés Bello” in Caracas, Venezuela in 1993 and completed her Master degree in Biochemistry at IVIC in 1998. She has completed his Ph.D. degree at Friedrich Schiller University in Jena in 2002. Her investigations focused on the development of new potent thrombin inhibitors by genetic engineering, modifying the structure of natural inhibitors isolated from blood sucking animals. Between September 2010 and July 2013, she spents a research visit as Humboldt-Fellow for 18 months in the Department of Biochemistry, Medical School, Justus-Liebig-University, Giessen (Germany). Presently, he is working on the role of thrombin, the central enzyme of the coagulation system beyond the hamostasis and its association to inflammation, cancer and immunity.
1) Development of thrombin inhibitors by biotechnological tools and techniques.
2) Biochemistry and pharmacology of direct Thrombin Inhibitors
3) Preclinical pharmacokinetik studies of anticoagulants
4) Interactions between coagulation and inflammation
5) Experimental Pharmacotherapy of tumors and inflammatory processes by blockade of activation of proteases activated receptors.
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