Affilation: Oregon Health and Science University, USA
Journal Associated: Journal of Genetic Medicine and Gene Therapy
During the course of my graduate studies in Prof. Christoph Klein’s laboratory, I primarily focused on understanding the molecular genetic cause of early onset inflammatory bowel disease (EO-IBD). Using homozygosity mapping and candidate gene sequencing, we have identified loss-of-function mutations in the IL10R or IL10 genes of 19 patients with severe and therapeutically refractory EO-IBD. Since I have significantly studied the molecular pathomechanisms of IBD for the past five years, I developed a keen interest in understanding and targeting the carcinogenic pathways that are activated during chronic inflammation and hencejoined Prof. Lisa Coussens laboratory on November 2014, for my postdoctoral research. Prof. Coussens is a renowned leader in the field of cancer immunobiology and has an extensive record of training postdoctoral fellows. The overall goal of my current project is to develop biomarkers to predict immunotherapy response that can be identified in non-invasively collected patient samples such as the peripheral blood. Specifically, I am monitoring T cell and B cell responses to immune therapy by evaluating clonality and diversity of T cell and B cell receptors (TCR and BCR, respectively) in tumor biopsies and in the circulating blood with the aim of identifying TCR and BCR signatures as molecular correlates of immunotherapy success.
Genomics, Gene Therapy, T cell based therapies, Tumor Immunology
to find colleagues at Heighten Science Publications