Affilation: Institute of Cell Biology and Neurobiology, Italy
Journal Associated: Journal of Neuroscience and Neurological Disorders
Dr. Cinzia Volonté, is Senior Scientist at the Institute of Cell Biology & Neurobiology of National Research Council (CNR) in Rome, Italy, since 2003, and in 2015 she has obtained the national qualification for Full Professor in Biochemistry and in Molecular Biology. Since 1998, she also leads the Cellular Neurobiology Unit at Santa Lucia Foundation in Rome. In 1992, Dr. Volonté has obtained a tenured research position at the Institute of Neurobiology of CNR, founded by the Nobel Prize Rita Levi-Montalcini, after having performed postdoctoral research with Prof. Efraim Racker at Cornell University, Ithaca, USA (1985-1987), and with Prof. Lloyd A. Greene at Columbia University, New York, USA (1987-1992). She graduated in Biological Science at University of Rome Sapienza in 1985. Her work has been published in journals among which Journal of Cell Biology, Journal of Biological Chemistry, Journal of Neuroscience, Molecular Biology of the Cell, Cerebral Cortex, Human Molecular Genetics, Cell Death and Differentiation, Pharmacology and Therapeutics, Progress in Neurobiology, and was compiled into patents granted for instance in Europe, USA, Canada, China and Japan. Dr. Volonté serves as editorial board member for Purinergic Signalling, and CNS & Neurological Disorders-Drug Targets. Dr. Volonté's research has provided contributions to the understanding of purinergic signalling in neurodegenerative and neuroinflammatory conditions as those occurring during glutamate-evoked excitotoxicity, ischemia, multiple sclerosis and amyotrophic lateral sclerosis. She has also investigated the functional outcome and signal transduction mechanisms sustained by extracellular ATP and Nerve Growth Factor in neuronal and glial cells. The main research interests in Dr. Volonté’s laboratory are now focused on the pharmacological, molecular and functional cell-specific characterization of ionotropic P2X and metabotropic P2Y receptors for extracellular nucleotides in the nervous system under physiological and pathological conditions and, moreover, on the analysis of the complex transduction mechanisms and molecular pathways triggered by purinergic ligands in neuronal and glial cells particularly during neurodegeneration and neuroinflammation. Through the years, this research activity has recognized that activation of P2 receptors can exert either detrimental or beneficial effects depending on the cell phenotype and extracellular environment, and that P2 receptors never behave as single units, rather they act in concert in a generally integrated and associative receptor web.
Neurodegenerative and Neuroinflammatory conditions; ischemia, multiple sclerosis and amyotrophic lateral sclerosis