Affilation: Rue University, Canada
Journal Associated: Journal of Genetic Medicine and Gene Therapy
Dr. Asangla Ao received her PhD in Genetics and Biometry from UCL, London, UK and her postdoctoral training in the USA (University of Michigan, Ann Arbor; University of Arizona, Tucson). She then worked as a senior research scientist in Royal Postgraduate medical school at Hammersmith hospital, London, UK where she performed pioneering work in the field of Preimplantation Genetic Diagnosis (PGD). At present, Dr Ao is the Scientific Director of PGD programme at McGill University health centre - Reproductive Centre and an Associate Professor in the Department of Obstetrics and Gynecology and Department of Human Genetics. Dr Ao’s research interest includes origin and mechanism of chromosome abnormality in human embryos, gene expression in mammalian preimplantation embryos and preimplantation genetic diagnosis.
Chromosome abnormality is one of the most common causes of pregnancy loss in women. Among those that survives to term often results in mental retardation, congenital malformation and neonatal death. The vast majority of these abnormalities is numerical and originates from maternal meiotic errors during oogenesis. This lab’s main research focus is to investigate the incidence and mechanisms involved in chromosome abnormality in early human embryos and its effect in preimplantation development. The knowledge we gain by these studies not only helps our basic understanding of early human embryo development but will help us to develop new clinical approaches in assisted reproduction technology. Key words: aneuploidy, in vitro fertilization, Preimplantation genetic diagnosis, chromosome mosaicism, Infertility, Inherited genetic disease, chromosome translocation, FISH, aCGH, NGS.