Affilation: Albert Einstein College of Medicine, USA
Journal Associated: Archives of Biotechnology and Biomedicine
During the first years spent in research at the University of Naples "Federico II” (Italy) I studied the role of chronic hyperglycemia in the pathogenesis of impaired insulin secretion and my goal was the identification of the molecular mechanisms involved in glucosamine-mediated ER stress in beta cell dysfunction. Later, during my PhD program at the University of Salento (Italy), I demonstrated the mechanistic role of beta 2 adrenergic receptor in insulin release.
In 2012 I joined the division of endocrinology at the Icahn School of Medicine at Mount Sinai (New York) as a postdoc, and during the years spent there I have been studying the cellular and molecular mechanisms underlying the pathophysiology of Autoimmune Thyroid Disease and Type 1 Diabetes. I led 2 studies on Graves’ disease patients identifying new single-nucleotide polymorphisms associated with Graves’ disease. Moreover I directed 2 projects evaluating the effect of ER stress in thyroglobulin and insulin folding and function exploring a novel model that triggers autoimmune disease. In 2016 I joined the department of medicine at the Albert Einstein College of Medicine as a faculty member where I’m now leading several projects aimed to develop therapies to prevent and treat autoimmune destruction of beta cells and thyroid cells. My ultimate goal is to define the molecules involved in such a process to specifically target their pathways and treat autoimmune thyroiditis and Type 1 Diabetes.
Diabetes, Thyroid Disease.
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