Fetal Alcohol Spectrum Disorders – What does it mean?

OPEN ACCESS Prenatal alcohol exposure is one of the most important causes of preventable cognitive impairment in the world. The developing neurological system is exquisitely sensitive to harm from alcohol and there is now also substantial evidence that alcohol-related harm can extend beyond the individual person, leading to epigenetic changes and intergenerational vulnerability and disadvantage [1].

Prenatal alcohol exposure is one of the most important causes of preventable cognitive impairment in the world. The developing neurological system is exquisitely sensitive to harm from alcohol and there is now also substantial evidence that alcohol-related harm can extend beyond the individual person, leading to epigenetic changes and intergenerational vulnerability and disadvantage [1].
The adverse effects of alcohol on the developing human comprise a spectrum of structural anomalies and behavioral and neurocognitive disabilities, most accurately termed fetal alcohol spectrum disorders (FASD). FASD continuum includes fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (PFAS), alcohol related birth defects (ARBD), and alcohol related neurodevelopmental disorder (ARND), allowing for more reproducible and accurate FASD diagnosis in a clinical setting [2] and there has been proposal for name change.
Fetal Alcohol Spectrum Disorders (FASD) thus includes a continuum of disorders that occur in children as a result of their mothers' consumption of alcohol during pregnancy. The most severe of these disorders is Fetal Alcohol Syndrome (FAS). FASD presents differently in every child, but all children with FASD have intellectual and/or behavioral impairments [3]. In general, FASD includes a pattern of retarded growth and development, both neuropsychological and physical, with typical facial dysmorphic features, found in some children exposed to alcohol during pregnancy. The signs and symptoms of FASD may include any mix of physical defects, intellectual or cognitive disabilities, and problems functioning and coping with daily life. This is therefore termed Fetal Alcohol Spectrum Disorders (FASD) rather than previous term FAS which is now used only to describe the most severe type of FASD. Some doctors prefer to call it FAE (Fetal Alcohol Effects) for less severe phenotype [2].
A spectrum of physical and neurodevelopmental abnormalities has been attributed to the effects of alcohol on the fetus. Effects seen in a child and the diagnosis reached depend on the duration of exposure to substantial maternal alcohol consumption during pregnancy, the range and timing of peak blood-alcohol levels, the nutritional state of the mother, and individual susceptibility [4]. Interestingly, the level of maternal consumption that produces Fetal Alcohol Spectrum Disorders (FASD) has not been established and is in luenced by genetic as well as other maternal and fetal characteristics.

Symptoms
The manifestations of FASD varies widely. Some children are affected much more than others. Children with less severe phenotypes in the FASD continuum present an even greater diagnostic challenge, because often the physical signs are more subtle. Some manifestations appear early and others appear or recognized quite late. The less severe types of FASD are much more common than FAS, however, and may affect ≥ 1% of all children born in the United States. The range of alcohol damage during fetal development, from mild to severe, is well documented in the medical literature and may manifest in physical, behavioral and social indices. A fetal alcohol behavior scale have been proposed [5].
Autti-Rämö, et al. [6], has tried to completely clinically characterize the structural and learning/behavioral phenotypes of a large cohort of older children and adolescents with moderate to severe disability within the FASD continuum, however it hasn't been much successful. There is also an attempt to rename and have Revised IOM Diagnostic Criteria and to develop scoring of features, however no consensus reached. The most important way of people identify FASD is still clinical. It has a variety of features which can be divided into 3 groups although there is some overlap.

Behavioural and social issues
Problems in functioning, coping and interacting with others may include: An excess of psychopathology, (including hyperkinetic disorders, emotional disorders, sleep disorders, and abnormal habits and stereotypes) with a strong persistence over time was found [7,8].
In a study speci ically designed to look for the effects on Developmental Behavior, there were signi icant differences (p = 0.01) between the groups on ive of six subscales of the Developmental Behavior Checklist (DBC) with controls scoring lower on the disruptive, self-absorbed, anxiety, antisocial behavior, and communication disturbance scales. The DBC pro iles of the two foetal alcohol exposed groups did not differ in FAS and FAE or age-and sex-matched control children with unspeci ic intellectual disability [8]. ADHD children were 2.5 times more likely to be exposed to alcohol in utero [9].

What happens to the brain
There may be no visible change in the brain images in FASD, however in a study MRI and single photon emission computed tomography (SPECT) to ind speci ic areas of abnormality showed that morphological anomalies were situated both cortically and subcortically. The abnormalities included cortical atrophy, dilated ventricle, corpus callosum hypoplasia, cerebellar atrophy etc. Delayed myelination of the white matter was seen in two patients. Volumetric studies of the hippocampus showed morphological left-right asymmetry in ive of eight patients. SPECT showed mild hypo perfusion of the left hemisphere and a negative left-right index was located especially in the left parietooccipital region, i.e. in the brain areas implicated in arithmetical and logical-grammatical functions, which are known to be affected in FAS. Normal leftright dominance was also lacking in the frontal area, i.e. the brain area affected in attention-de icit-hyperactivity disorder (ADHD). Detection of these abnormalities, although they are not unique to FASD, may be helpful in the diagnosis and any attempts at rehabilitation [10]. https://doi.org/10.29328/journal.cjog.1001043

What to do if you suspect FASD
If you're pregnant and suspect that you have dif iculty to stop drinking, ask your obstetrician, primary care doctor or mental health professional for help early. They can assess and provide help or point in the right direction. Since early diagnosis may help reduce the risk of long-term problems for children with fetal alcohol syndrome, an early discussion or advice from a pediatrician may also be helpful.
If you have adopted a child or are providing foster care, you may not know if the biological mother drank alcohol while pregnant, and it may not initially occur to you that your child may have FASD or fetal alcohol syndrome. It is better to express your suspicion, specially, if the child has problems with learning and behavior.