HSPC Articles

Articles Library

10/12/2019
Research Article

Synthesis of NaYF4:Yb,Er@SiO2@Ag core-shell nanoparticles for plasmon-enhanced upconversion luminescence in bio-applications

Grigory Arzumanyan*, Dmitriy Linnik*, Kahramon Mamatkulov, Maria Vorobyeva, Anastasia Korsun, Valentina Glasunova and Anka Jevremovic

The present report highlights our results on synthesis of NaYF4:Yb,Er@SiO2@Ag core–shell nanoparticles (CSNPs) for plasmon-enhanced upconversion luminescence (UCL). Hydrophilic surface UCL nanoparticles (UCLNPs) as cores were obtained by precipitation of Rare Earth Elements (REE) chlorides from water-alcohol solutions. The formation of a hydrophobic surface of α-NaYF4:Yb,Er NPs was achieved by thermolysis method at 280 °C and β-NaYF4:Yb,Er by precipitation method in nonpolar medium at 320 °C. Silica shell was formed by the modified Stöber method on the surfaces of UCLNPs with different polarity and phase composition. A mixture of hexane-cyclohexane-isopropyl alcohol was used as a medium for the formation of mononuclear CSNPs on hydrophobic surfaces of cores with different thicknesses of the silica shell: 5 nm and 14 nm. Formation of a predetermined thickness of silica shell was carried out by introducing a precise quantity of TEOS taking into account the size of core NPs with molar ratio TEOS: H2O equal to 1:6. The morphology and phase composition of cores and CSNPs were examined by transmission electron microscopy and selected area electron diffraction, respectively. The insertion of Ag NPs into the structure of NaYF4:Yb,Er@SiO2 was carried out in parallel at the stage of shell formation, which made this synthesis a one-step process. The control of the size of Ag NPs was implemented through the use of a colloidal solution of NPs of the cluster structure by changing the polarity of the medium. The highest intensity enhancement of 85-fold with 5 nm and 29-fold with 14 nm shell thickness was recorded, respectively. For the first time, tests on bioimaging of neutrophil cells by those CSNPs are demonstrated.

09/26/2019
Research Article

Haemostasis with suture-tourniquet technique following removal of large-bore venous sheaths for endovascular recanalization of acute thrombosis in native arteriovenous fistula

Omur Balli*

Purpose: To investigate the suture-tourniquet technique for haemostasis in patients with acute thrombosis of native arteriovenous fistula (AVF) whom underwent manual aspiration thrombectomy using large-bore venous sheaths and high dose heparin.

Methods: Between January 2016 and May 2018, patients with acute AVF thrombosis performed successful manual aspiration thrombectomy by using large bore venous sheaths and high dose heparin were included in this retrospective study. Success rate for haemostasis, procedural complications clinical and imaging follow up was reported descriptively.          

Results: A total of 52 patients with 64 procedures met the inclusion criteria. In 60(94%) of 64 procedures, successful haemostasis was achieved with suture-tourniquet technique.  In 2(3.1%) of the 64 procedures, the suture broke while turning the tourniquet and haematoma occurred in another 3 procedures (4.7%) although suture-tourniquet technique was applied appropriately. Manual compression was performed in these patients. There were 3 major complications unrelated the suture-tourniquet technique.

Conclusion: The suture tourniquet technique can achieve haemostasis rapidly and can be safely used with low complication rates without fistulae thrombosis after large-bore venous sheath removal following treatment of AVF thrombosis.

10/01/2019
Research Article

Tamsulosin and Dementia in old age: Is there any relationship?

Rebecca Renata Lapenda do Monte, Karina de Andrade Vidal Costa, Arnaldo Santiago Nunes Junior, Amália Cinthia Meneses Rêgo, Irami Araújo-Filho*

Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH.

10/02/2019
Case Report

Fatal agranulocytosis associated with Metamizole treatment in a 16-year-old girl

Packo Dieu-le-veut Saint-Cyr Sylvestre*, Nanho Danho Clotaire, N’dhatz Comoe Emeraude, Boidy Kouakou, Camengo Police Serge Magloire, Diakité Mamady, Mbelesso Pascal, Koffi Kouassi Gustave

Agranulocytosis is one of the common reasons of consultation in hematology. It’s lifethreatening because of an infection risk. The metamizole is a drug, known for its potential rare danger of inducing a severe agranulocytosis.

09/30/2019
Case Report

Automatic heartbeat monitoring system

Franchini Roberto*

The proliferation and popularity of open source hardware and software, such as Arduino and Raspberry PI, together with IoT and Embedded System, has brought the health industry to rapid evolution, creating portable and low-cost medical devices for monitoring vital signals.

09/24/2019
Case Report

A rare case of recurrent urinary tract infection due to Trichosporon species in an immune-competent diabetic female patient

Saroj Adhikari, Bhuvan Saud*, Govinda Paudel, Sunita Wagle

Trichosporonosis is a disease caused by Trichosporon spp. which are ubiquitous anamorphic yeast that commonly inhabit the soil. In human they are found in the skin, gastrointestinal tract and respiratory tract.

09/27/2019
Research Article

Screening of antibiotic residue in poultry in Kathmandu valley of Nepal: A cross-sectional study

Rajiv Sapkota*, Ramila Raut, Sujan Khanal, Muna Gyawali and Dipesh Sahi

This cross-sectional study was conducted to screen the presence of antibiotic residue in poultry. A total of 60 samples (30 Muscle and 30 Liver) were taken from local meat shops from different parts of Kathmandu valley.

09/20/2019
Research Article

The association between hypoxia, chronic ischemia and alters prostate structure and progress of chronic prostatic disease

Mauro Luisetto*, Behzad Nili Ahmadabadi, Ghulam Rasool Mashori, Gamal Abdul Hamid

Chronic prostatitis today show high level of relapses and recurrent pathological events even if using the best pharmacological therapy. A better understanding of physiopathological effect of ischemic hypoxic condition (pelvic, prostate tissue) and the lymphatic congestion in same body region contribute in evolution of a complex condition.

09/19/2019
Research Article

Prevalence of disabling hearing loss in the elderly

Leticia Raquel Baraky Vasconcelos, Paula Ferraz Rodrigues, Paula Liziero Tavares and Audryo Oliveira Nogueira*

Introduction: Disabling hearing loss refers to hearing thresholds superior than 40 dB in the better ear in the adults. The main cause of hearing loss in the elderly is the age-related hearing loss, also called presbycusis. This type of hearing impairment occurs as individuals grow older and is usually sensorineural hearing disorder greater for high-pitched sounds and affects both ears equally. It is estimated that 466 million people worldwide have disabling hearing loss, one third of which are over 65 years old.

Objective: To analyze the prevalence of disabling hearing loss in the elderly of Juiz de Fora.

Methods: Cross-sectional study with 122 patients. Pure tone audiometry was performed after meticulous physical examination of the external ear.

Results: Out of 122 older adults, 85 (69,6%) presented disabling hearing loss.

Conclusion: Hearing loss, specially disabling hearing loss, is a frequent condition in the elderly and has a big impact on their quality of life. For that it should be promptly diagnosed so treatment can be initiated.

Case Report

Occipital lobe ependymal cyst with unusual presentation

Okacha Naama*, Abdelilah Idir and Omar Boulahroud

Intraparenchymal cysts without communication to the ventricles or the subarachnoid space are named ependymal or epithelial cysts. The estimated ratio of their incidence compared with arachnoid cysts is 1:10.

10/10/2019
Review Article

Three modern serological methods to detect plant viruses

Mahmoud Hamdy Abd El-Aziz*

The use of enzyme linked immunosorbent assay (ELISA) for the detection of plant viruses is well documented. It proved to be a very valuable detection tools for the plant viruses. The efficiency of the ELISA technique was for practical purpose independent of the ratio of antibodies to antigen.

10/04/2019
Research Article

Comprehensive phenotypic characterization and genetic distinction of distinct goosegrass (Eleusine indica L. Gaertn.) ecotypes

Robert A Kerr*, Tatyana Zhebentyayeva, Christopher Saski, Lambert B McCarty

Goosegrass (Eleusine indica L. Gaertn.) is a troublesome weed in turfgrass systems throughout the world. The development of herbicide resistant ecotypes has occurred to multiple modes of action. Goosegrass is a prolific seed producer (~50,000 per plant), fast growing and diverse weed.

Research Article

Serological and molecular characterization of two seed born cowpea mosaic Comovirus isolates affecting cowpea plants (Vigna unguiculata L.) in northern Egypt

Mahmoud Hamdy Abd El-Aziz*, Hosny Aly Younes

Cowpea plants naturally infected with cowpea mosaic comovirus (CPMV) showed different mosaic, mottle, dwarfing, and vain clearing symptoms. Diseased plants were ollected from certain locations of Alexandria and El-Beheira governorates during the growing seasons from 2011 to 2012.

09/13/2019
Review Article

Avermectins: The promising solution to control plant parasitic nematodes

Mohamed S Khalil*, Dalia M Darwesh

Abamectin and emamectin are members of avermectin family which categorized as very effective but in the same time are toxic naturally. Most of products in this family are utilized as pharmaceuticals in both humans & animals and for crop protection.

09/18/2019
Research Article

Low back pain induces disability of women in primary uncomplicated pregnancy

Panagiotis Korovessis*, Rania Antonaki, Spyridon Zacharatos, Vasileios Syrimpeis

Study design: A consecutive case series study

Purpose: To investigate whether Low Back Pain (LBP) in women with primary singleton pregnancy induces disability.

Background: LBP is reported to be increased in pregnants than in non-pregnant women. Different outcome measures have been used to search for correlations between pain and disability.

10/01/2019
Editorial

The rising role of natural killer cells in patients with malignant hematological disorders and in recipients of hematopoietic stem cell transplantation

Khalid Ahmed Al-Anazi*

Natural killer (NK) cells, the third population of lymphoid cells, comprise 5%-25% of peripheral blood (PB) lymphocytes and represent the first line of defense against infections and tumors [1-7]. They can be derived from: bone marrow, PB, cryopreserved umbilical cord blood (UCB), human embryonic stem cells (hESCs), induced pluripotent stem cells (iPSCs), and various cell lines such as NK-92 and KHYG-1 [1].

09/04/2019
Review Article

Advances in the use of GABAergic interneurons for the treatment of epilepsy

Federica Frisina, Giulia Valetti, Giulia Zuccarini, Luciano Conti, Giorgio R Merlo*

Forebrain GABAergic neurons, the main inhibitory type of neuron in the cortex and hippocampus, represent a highly heterogeneous cell population that has been implicated in the predisposition to epilepsy and the onset of seizure. Earlier attempts to restore inhibition and reduce seizure in animal models of epilepsy have been carried out using embryonic basal forebrain tissue as source of immature GABAergic progenitors in cell-based therapies, with promising results. For therapeutic strategies this approach appears unrealistic, while the use of pluripotent stem cells to obtain immature GABAergic neurons opens new and promising avenues. Research on neural stem cells and pluripotent stem cells has greatly advanced and protocols have been established to efficiently direct progenitor cells to differentiate towards the GABAergic lineage. However, being highly heterogeneous, these neurons are difficult to be fully represented in vitro. Better knowledge on the expressed gene profiles, at single cell level, and the differentiation trajectory of these neurons will consent a more precise monitoring of the differentiation steps. Here we review the current literature about how to obtain and characterize genuine inhibitory neurons, how these can be grafted in animal models (and one day possibly in human) and which diseases could potentially be targeted and the efficiency of therapeutic outcome. The main obstacles that need to be overcome are: a) choice of an appropriate animal model, b) availability of human cells prone to GABA differentiation, c) the full representation of all IN subtypes, their proportions and their physiological activities, d) how to monitor them on the long-term after transplant.

09/27/2019
Research Article

Glycemic status and its effect in Neonatal Sepsis - A prospective study in a Tertiary Care Hospital in Nepal

Badri Kumar Gupta*, Binod Kumar Gupta, Amit Kumar Shrivastava, Pradeep Chetri

Introduction: Sepsis is an important cause of morbidity and mortality among neonates. Neonatal sepsis can alter the glucose level and both hypoglycemia and hyperglycemia may occur. A high or low blood glucose level may have a significant effect on the outcomes in patients of neonatal sepsis.

Aims: The aim of the study to see the glycaemic status and its effect on outcome of neonatal sepsis.

Material and Methods: This hospital based prospective observational cross-sectional study was conducted in Neonatal Intensive Care Unit in Universal College of Medical Sciences, a tertiary care hospital over a period of 4 months, from May 2019 to August 2019. A total of 220 Neonates suspected sepsis under the age of 28 days admitted in NICU, were studied and included in our study. Clinically suspected neonatal sepsis cases were enrolled in the study. Venous blood was collected before giving any intravenous fluid, dextrose or antibiotics and blood sugar, complete blood counts, CRP levels and blood culture were send to laboratory within half hour of collection. All patients included in this study were treated accordingly and followed up strictly. Blood glucose level and mortality of neonates having hypoglycemia, hyperglycemia were analyzed among CRP and culture positive patients. Quantitative data were expressed as mean and standard deviation. Qualitative data were expressed as frequency and percentage and comparison carried by Chi-square (χ2) test.

Results: A total of 220 patients clinically diagnosed as neonatal sepsis were studied. 118 (53.6%) patients were found CRP positive and 56 (25.5%) patients were blood culture positive. Glycaemic status was analyzed among CRP and culture positive patients. Majority (55.9%) patients were found normoglycemic, 35.5% were found hypoglycemic and 8.6% were found hyperglycaemic in this study. 182 (82.73%) patients were cured and 38 (17.27%) died. Mortality was high in hypoglycaemic patients (34.4%) compared with normoglycaemic patients (9.82%), but the difference was not statistically significant (p > 0.05) between two groups, the mortality was high in hyperglycaemic patients (58.33%) compared with normoglycaemic patients (9.82%) and the difference was statistically significant (p < 0.05) between two groups.

Conclusion: Alteration of glycaemic status occurred in septic newborn. Mortality is higher among the septic newborn with hyperglycemia. The present study found that majority of neonate with sepsis had high mortality rate when blood glucose level were either more than 145 mg/dl or less than 45 mg/dl. This signifies the importance of meticulous blood glucose estimation in cases of neonatal sepsis to improve mortality outcome.

09/03/2019
Research Article

Does it matter what a mother consumes? An anthropological exploration of dietary practices among Churachandpur (Manipur) pregnant women and its impact on infant birth weight

Evelyn Ngaithianven, JS Sehrawat* and Reetinder Kaur

Background: Nutritional status of expectant women is an important indicator of healthy pregnancy and an ideal birth weight of the infant. The present study is an attempt to understand food eating practices and related taboos among the Paite women and whether or how these practices influence weight gain among infants during their first year of life.

Methods: The longitudinal study was conducted for a period of 16 months between November 2010 and February 2012) among 186 Paite mother-infant pairs. Women who had completed 37 to 42 weeks of pregnancy were included. Infant’s weights were measured using standard technique and information on mothers’ food related practices was recorded during the house visit using a structured schedule. Standard statistical methods were used for description and analysis.

Results: A peculiar practice, ‘pica’ was observed among a few women. A number of food taboos were found to be followed by the ‘Paite’ women during course of their pregnancy.

Conclusion: No significant difference was noticed in the mean weight of babies from birth through the age of 1 year between mothers practicing and not practicing food taboos. However, it was found that the mean weight of the babies throughout the study period was comparatively higher among non-taboo mothers. It could be suggested that women must be counseled during their antenatal and postnatal visits to the maternity clinics and hospitals about dietary practices and their anticipated impact on health of the newborns.

10/04/2019
Research Article

Plaque morphology in diabetic vs. non diabetic patients assessed by Multi-Slice Computed Tomography coronary angiography

Hesham Mohamed Aboul-Enein, Amr Elsayed El Naggar, Shereen Ibrahim Farag, Waleed Atef Ahmed Hassan*

Background and Objectives: Multi-slice computed tomography (MSCT) provides high accuracy for noninvasive assessment of coronary artery disease (CAD). The introduction of the latest computed tomography technology allows comprehensive evaluation of various aspects of CAD, including the coronary calcium score, coronary artery stenosis, bypass patency, and myocardial function. This study aimed to assess the effect of DM on coronary arteries evaluated by MSCT-CA Comparing Plaque Morphology in Diabetic patients with Non-Diabetic Whoever Controlled or not assessed by HbA1c.
Methods: In this study we randomly assigned 150 adult patients were diagnosed with suspected coronary artery disease underwent MSCT-CA for evaluation their coronaries regarding luminal stenosis, Plaque analysis, Remodeling index, SSS, SIS and Ca score.
Results: There was statistically significant difference between diabetics & non-diabetic groups in LM lesions with (P = 0.029). also, the results of multivariate logistic regression analysis after adjustment for age and sex, diabetics were shown a trend toward more mixed plaque with statistically significant {(OR): 3.422, 95% CI 1.66-7.023, P = 0.001}; whereas, after adjustment for age, sex, history of hypertension, smoking, and hypercholesterolemia, patients with diabetes also shown a trend toward more mixed plaque with statistically significant (OR: 3.456, 95% CI 1.668-7.160, P = 0.001). It means significant differences in coronary atherosclerotic plaque burden and composition between diabetic and non-diabetic patients, with a higher proportion of mixed plaques, a more vulnerable form of atherosclerotic plaque in diabetics (P < 0.001) otherwise No significant difference.
Conclusion: MSCT angiography may be useful for the identification of CAD in diabetic and non-diabetic patients. There were statistically significant differences in coronary atherosclerotic plaque burden and composition, with a higher proportion of mixed plaques, between diabetic and nondiabetic patients. Furthermore, MSCT may give accurate information about plaque characteristics according to different coronary risk factors, thereby identifying high risk features warranting a more intensive anti-atherosclerotic treatment.

10/04/2019
Case Report

Scintigraphic non-invasive diagnosis of amyloid cardiomyopathy

Laroussi Mohamed-Salem*, Tomas E Rodríguez-Locarno, Tatiana Moreno-Monsalve, Isabel Castellon-Sanchez, Jose F Contreras-Gutierrez and Antonia Claver-Valderas

Amyloidosis encompasses a heterogeneous group of disorders, characterized by extracellular deposition of insoluble abnormal amyloid aggregates, due to a failure in protein quality control. Cardiac amyloidosis is a disorder in which proteins misfold and deposit as amyloid fibrils that infiltrate the myocardial extracellular space [1].

09/26/2019
Research Article

Prevalence of congenital heart diseases among primary school children in the Niger Delta Region of Nigeria, West Africa

Ujuanbi Amenawon Susan*, Tabansi Petronilla Nnena, Otaigbe Barbara Edewele

Introduction: Congenital heart diseases (CHD) are leading causes of childhood morbidity and mortality especially in developing countries. Community-based studies are important in ascertaining the burden of the disease.

09/24/2019
Research Article

Novel paclitaxel-coated balloon angioplasty via single retrograde popliteal access for challenging superficial femoral artery and iliac artery lesions?

Erdem Cetin*, Celal Selcuk Unal, Aydın Keskin, Hakan Kartal

Objectives: We report our results regarding the use of BioPath™ paclitaxel-coated balloon catheters for superficial or distal external iliac artery revascularization via single retrograde popliteal access.
Methods: We included 105 prospective consecutive patients. Single retrograde popliteal access was achieved under ultrasound guidance with the patients laid prone. An over-the-wire atherectomy system was used if risk of distal embolization was high due to plaque intensity of the target lesion. A 4 to 7 mm-diameter BioPath™ 035 balloon catheter was used for all lesions. Follow-up at 6th month included doppler ultrasound examination for patency.
Results: Seventy-two patients (68.6%) had total SFA occlusion and 41 patients (39%) had concomitant external iliac artery involvement, out of whom 31 (29.5%) had total occlusion. Procedural success 90.5% for superficial femoral artery and 85.3% for external iliac artery. One-year patency rates in SFA and EIA were 84.8% and 80.4%, respectively
Conclusion: Single retrograde popliteal access and drug-coated balloon angioplasty may offer a useful alternative to known modalities in treatment of challenging superficial femoral artery and concomitant iliac artery lesions.

09/20/2019
Research Article

Prediction of Left Ventricular Systolic Dysfunction after 6 months of Aortic Valve Replacement in patients with Chronic Severe Aortic Regurge

Ahmed S Ammar, Mohammad Gouda*, Mohammad Hassan

The natural history of chronic severe aortic valve regurgitation (AR) is characterized by a prolonged period of preserved global left ventricular (LV) systolic function and compensated eccentric hypertrophy, which insidiously gives way to myocardial decompensation [1].

09/20/2019
Research Article

Arrhythmia of the heart - computer analysis

VI Kaganov*

The problem of synchronization of oscillations of various physical nature is discussed. From the standpoint of the theory of synchronism, a model of the heart is considered as a system of four connected between self-oscillating links: two atria and two ventricles.

09/27/2019
Research Article

Results of chemotherapy in the treatment of chronic lymphoid leukemia in Black Africa: Experience of Côte d’Ivoire

N’dhatz Comoe Emeraude, Packo Dieu-le-veut Saint-Cyr Sylvestre*, Nanho Danho Clotaire, Bognini Sarah, Kamara Ismael, Boidy Kouakou and Koffi Kouassi Gustave

Background: The treatment of chronic lymphoid leukemia currently uses news drugs which are more expensive in our countries. Its why, the results of chemotherapy remains a challenge in our sector.

Aims: To evaluate the place of polychemotherapy in the treatment of chronic lymphoid leukemia in black Africa.

Methods: It was a prospective, descriptive, analytic and non-comparative study, concerning the records of patients with chronic lymphoid leukemia treated and followed at the department of clinical hematology in Abidjan.

Results: We included 56 patients. The average age was 62 years with extremes of 38 and 84 years. The sex ratio was 0.8 in favor of female. The clinical signs noted a tumor syndrome among which splenomegaly, classified stage III (46, 43%) and adenopathy (64, 29%). Biologically, we observed a blood lymphocytosis (50%), an anemia (39.29%) and a thrombocytopenia (62.50%). The majority of patients were classified stage A of BINET (51.79%). The COP protocol (44.64%) and the monochemotherapy with chlorambucil (39.29%) were the most used. The therapeutic response of polychemotherapy was low (12.5%) compared to 35, 71% for monochemotherapy (p = 0.0001) with overall survival significantly better in monochemotherapy. The outcome of patients used polychemotherapy were more adverse that of patients used chlorambucil alone (p = 0,003). The overall probability of survival at 12 months was 90, 9% for patients who used monochemotherapy and 63, 4% for polychemotherapy.

Conclusion: Polychemotherapy in chronic lymphoid leukemia of black African has an adverse therapeutic response hence the interest of using new therapeutic possibilities.

09/18/2019
Review Article

A mouse model of coronary microvacsular disease using a photochemical approach

Xinlu Wang, Fang Liu and Zhen W. Zhuang

The development of reproducible rodent models of coronary microvascular disease (MVD) is essential for the early detection, treatment, and mechanism study of the pathophysiology. We hypothesized that endothelial dysfunction and subsequent microthrombi in the coronary arterioles, two early events in clinical coronary MVD, could be reproduced by photochemical reaction (PCR) technology in mice hearts.

09/13/2019
Case Report

Anomalies of coronary artery origin: About two cases

Dioum M*, Sarr EM, Manga S, Mingou JS, Diack A, Diop AD, Bindia D, Diagne PA, Sarr AN and Diop IB

Anomalies of coronary artery origin are congenital malformations characterized by the abnormal birth of a coronary artery from the controlateral coronary aortic sinus (birth of the left coronary artery from the right sinus or birth of the right coronary artery from the left sinus).

09/03/2019
Research Article

How often is Klippel-Feil Syndrome associated with congential heart disease presentation of five cases and a review of the literature

Ramush Bejiqi, Ragip Retkoceri, Arlinda Maloku, Rinor Bejiqi, Aferdita Mustafa, Faruk Husremovic and Samir Bejic*

Introduction: Klippel-Feil syndrome (KFS), is a bone disorder characterized by the abnormal joining (fusion) of two or more spinal bones in the neck (cervical vertebrae), which is present from birth. Three major features result from this abnormality: a short neck, a limited range of motion in the neck, and a low hairline at the back of the head.

09/18/2019
Research Article

Effect of laparoscopic salpingectomy on subsequent ovarian response after controlled ovarian hyperstimulation

Chadi Yazbeck*, Asma Boukadida, Christian Chauvin, Anne Laure Margulies and Ségolène Falcone

Background: The effect of salpingectomy on ovarian response is a matter of debate. Due to conflicting data, alternative techniques were developed to perform salpingectomy for treatment of hydrosalpinges in infertile patients. This study aims to evaluate the effect of salpingectomy on ovarian response after stimulation with gonadotropins.

08/27/2019
Research Article

The place of health innovation in space to improve the lives of earthlings

Brigitte Godard

For over twenty years, following the creation of space stations, MIR first and then the ISS (International Space Station) men (3 to 6) live and succeed each other continuously about 300 - 400 km of altitude to make scientific experiments. For this reason sending men into space has become an activity “almost banal or regular “but this remains potentially a very dangerous environment for the adapted manon Earth and thus requires medical monitoring to ensure the health of astronauts and the persistence of their ability during their mission. In general, the medical benefits on Earth of space conquest go far beyond envy and the need for man to discover the cosmos but to develop many tools medicines to also offer solutions for all living beings on Earth!

08/27/2019
Research Article

Evaluating cortical bone porosity using Hr-Pqct

Rique AM, Madeira M, Luis L, Fleius MLde F, Paranhos NF and Lima I*

This work aims to evaluate cortical porosity through a high-resolution peripheral quantitative micro-tomography in a group of 47 patients. All patients, in vivo, were subjected to the medical care protocol of the University Hospital Clementino Fraga, 020-213. Patients were women aged from 37 to 82 years old, who did not present fractures in their lower and upper limbs, all of them showing good health. During screening, they were required to have normal BMD (as determined by DXA; T-score ≥ 1.0) and no low-trauma fractures history.

09/24/2019
Research Article

Novel paclitaxel-coated balloon angioplasty via single retrograde popliteal access for challenging superficial femoral artery and iliac artery lesions?

Erdem Cetin*, Celal Selcuk Unal, Aydın Keskin and Hakan Kartal

Objectives: We report our results regarding the use of BioPath™ paclitaxel-coated balloon catheters for superficial or distal external iliac artery revascularization via single retrograde popliteal access.

09/11/2019
Research Article

The validity of progesterone level on hCG injection day in the prediction of IVF/ICSI cycles’ outcome

Mostafa A Abolfotouh*, Hallah Al-Anazi, Samar Hassan

Background: Previous studies highlighted the negative effect of premature progesterone elevation (PE) during IVF cycles on the cycle outcomes. The aim of this study was to assess the validity of progesterone level on hCG day (P4) in the prediction of IVF/ICSI cycles’ outcome. In a retrospective cohort study, all fresh cycles of 256 patients who underwent IVF or ICSI cycles in 2017 at reproductive endocrinology & infertility unit/ Obg/Gyn department at King Abdulaziz Medical city, Riyadh, Saudi Arabia, were followed up.

08/22/2019
Review Article

Management of Ischemic Stroke during cardiac catheterization: A case report and review of literature

Naoufal Chouaib*, Said Jidane, Mounir Lekhlit, Ahmed Belkouch, Tahir Nebhani, Saad Zidouh and Lahcen Belyamani

Stroke following coronary interventions is a devastating and most dreaded complication with significant morbidity and mortality. Various factors have been ascribed for this complication including the technical errors [1]. A small percentage of strokes are iatrogenic, including those associated with invasive cardiac procedures.

08/21/2019
Research Article

Risk factors of survival in breast cancer

Akram Yazdani*

Background: In this study, we aimed to investigate the role of prognostic factors on breast cancer survival in Iran.
Methods: This study was carried out using data from 500 participants with breast cancer. Data were gathered from medical records of patients referring to four breast cancer research centers in Esfahan, Iran, between 1990 – 2000. Age at diagnosis (year), size of tumor, Involve lymph nodes, tumor grade, and family history and married were the prognosis factors considered in this study. A Cox model was used.

09/09/2019
Research Article

An evaluation of visual outcome of corneal injuries in a tertiary care hospital

Aarudhra Premchander, Seema Channabasappa, Nischala Balakrishna* and Neha Nargis

Background: Corneal injuries are significant contributors to blindness. Cornea being the most anterior structure of eye is exposed to various hazards like airborne debris and blunt trauma. By understanding different types of injuries to which cornea is exposed, the practitioner maybe more capable in managing injuries to minimise structural and visual sequelae.

08/22/2019
Case Report

Unilateral retinitis pigmentosa: Case report and review of the literature

Denise Goodwin*, Amanda M Olsen and Karl Citek

Significance: Due to the limited number of reported cases little is known about the characteristics of unilateral retinitis pigmentosa. Information from additional case reports can aid in learning more about the condition. We report a case of retinitis pigmentosa that has remained unilateral for 28 years and review the available literature.

09/02/2019
Case Report

Weight loss counseling for dialysis patients to prepare for transplant

Karen F Factor*

Obesity has become a worldwide Epidemic affecting more than 300 million people. Overweight is defined as BMI (Body Mass Index) of 25-29.9 kg/m2. Obesity is defined as BMI greater than 30 kg/m2, and Morbid Obesity is a BMI of > than 35 kg/m2 [1].
 

09/12/2019
Case Report

A case report of an Erdheim-Chester patient focused on pain management

José Osvaldo Barbosa Neto*, Joao Batista Santos Garcia, Thiago Alves Rodrigues and Camila Freitas de Andrade Rodrigues

Introduction: Erdheim-Chester disease (ECD) is a rare and diffi cult-to-treat non-Langerhans cell histiocytosis characterized by the excessive production and accumulation of histiocytes. This study reports a case of ECD, emphasizing both its diagnosis, assessment and treatment of the
pain associated with the disease.

09/06/2019
Research Article

Outcome of laparoscopic varicocelectomy with mass ligation technique for symptomatic varicocele

Sardar Rezaul Islam*, Majedul islam, Shah Alam Sarkar and Shah Paran

Background: Varicocele therapy is a controversial issue. No single approach is adopted as the best therapeutic option. Testes get blood supply from testicular artery, cremasteric artery and artery to the vas deference. So ligation of testicular artery in the abdomen do not cause ischemia to the testis. This was already demonstrated in many studies. Classical Palomo varicocelectomy also consists of open ligation of testicular vessels in the retroperitoneum. En mass ligation of testicular vein and artery is technically easy and fast in laparoscopic varicocelectomy (LV). Chance of missing some veins are also less. Henceforth recurrence is also less. Recurrence and post-operative complications are high when only testicular vein is ligated by laparoscopy in the retroperitoneum. We wanted to see the outcome of laparoscopic varicocelectomy by mass ligation technique.
Methods: 56 patients of symptomatic varicoceles were included in the study from the outpatient services. Symptomatic varicoceles of grade 2 to grade 3 were operated from January 2012 till January 2019 over a period of 7(seven) years in Jahurul Islam Medical college Hospital. The patients were selected for dull pain and ugly veins not for infertility. All were operated by laparoscopy with en-mass ligation of testicular vein and artery in the retroperitoneum. They were followed up for a period of six months after surgery. We collected all the data in a retrospective manner.

Results: The average operation time was 27±3 minutes. Average post-operative hospital stay was 32±7 hours. There were no technical failures requiring conversion to open varicocelectomy. There was no incidence of hydrocele formation nor testicular atrophy. One patient of bilateral varicocele had 50% reduction of his varicocele. We considered this a recurrence. All other patient had complete reduction of varicocele. One patient developed hemo-peritoneum due to dislodgement of hemo-clip, which required laparotomy. He did not require any further surgery for his varicocele.

Conclusion: Laparoscopic varicocelectomy with mass ligation technique is safe, effective, less time consuming and easy to perform. Recurrence and post-operative complications are minimum. Plastic hemo-lock should be used rather than titanium heom-clip for ligation of testicular vessels. There is no incidence of testicular atrophy or any adverse effect on testis.

09/06/2019
Review Article

Extremely large hemangioma of the liver: Safety of the expectant management

Subhi Mansour, Sharbel Khouri, Maisa Andraous and Safi Khuri*

Hemangiomas are known as congenital vascular malformations that can affect almost any organ or tissue, with the liver being the most common intra-abdominal organ to be involved. It is well known that hemangiomas are the most common benign tumours of the liver, and develop in about 4-20% of people, mainly young adult females. Recently, due to the dramatic rise in the use of imaging studies for different purposes, a parallel increase in the incidence of these tumours has been noticed. Most liver hemangiomas are small (less than 4cm in diameter), asymptomatic and found incidentally during abdominal operation for other indication or on radiologic studies. Giant liver hemangioma is defined as hemangioma with a diameter of more than 5cm. This unique and uncommon type of haemangioma usually poses therapeutic challenges for the treating physician, especially hepatic surgeons, due to the unclear natural history, and due to the risk of life threatening complications is yet to be established. While it is already proved by several studies that conservative management of giant hepatic hemangioma is safe, it is not known whether observation of the extremely large hepatic hemangioma (tumours larger than 10cm) is safe as well.

The aim of this article is to review the English literature to find out if conservative management of the extremely giant liver hemangioma is safe and can be recommended.

08/26/2019
Case Report

Carotid artery disease: AngioCT features

Joana Ferreira*, Olinda Miranda, Alexandre Lima Carneiro, Sandrina Braga, João Correia Simões, Celso Carrilho, Amílcar Mesquita and Jorge Cotter

The objective of this paper is to emphasis the AngioCT features of carotid dissection/mural hematoma. The image show an internal carotid artery with narrowly eccentric lumen surrounded by a crescent-shaped hypodense mural thickening, with a visibly enhancing vessel wall. The carotid hematoma is a hypodense mural thickening that leads to expansion of the arterial wall, compression of the lumen and release of thrombogenic factors by intimal damage. Hematoma between the intima and media causes vessel expansion diameter and a narrow eccentric lumen. Peripheral hyper density is due to the contrast enhancement of the vasa vasorum in the adventitial layer. The physician should be familiar with the imagiologic features of carotid arterial disease, due to the diferent treatment options.

08/28/2019
Case Report

The Pierre Marie-Sainton syndrome: Report of a family

Salem Y*, Omar Y, Dorsaf S, Sonia M, Samir B and Olfa B

Pierre Maria and Sainton syndrome or cleido-cranial dysplasia (CCD) is a rare syndrome presenting an autosomal pattern of inheritance, characterized by characterized by a triad: clavicular aplasia, delayed ossification of the fontanelles and sutures of the vault of the skull. To these may be added multiple dental inclusions.

10/12/2017
Review Article

Wifi and health: Perspectives and risks

Myriam Ben Salah*, Hafedh Abdelmelek and Manef Abderraba

Increased exposure to electromagnetic fields such as radio frequencies used by Wifi technology raise questions and concerns about their impact on health. For answer these questions, several scientifi c studies have carried out followed by results publication in prestigious scientifi c revues.

09/02/2019
Review Article

Essential thrombocythemia: Biology, clinical features, thrombotic risk, therapeutic options and outcome

Accurso V, Santoro M, Contrino AD, Casimiro P, Raso S, et al.

Essential Thrombocythemia (ET) is currently classified as a Philadelphia negative myeloproliferative neoplasm (MPN) together with polycythemia vera (PV) and primary myelofibrosis (PMF); the latter can be further divided in pre-fibrotic primary myelofibrosis (pre-PMF) and overt myelofibrosis, as listed in the revised 2016 World Health Organization classification of myeloid malignancies (WHO 2016).

08/26/2019
Research Article

Gender and left ventricular structural and functional differences in pulmonary hypertension among end stage renal disease patients on maintenance hemodialysis

Malik U, Ajaaj I, Blaschke JP, Skipper B, McClelland SL, et al.

Introduction: Pulmonary hypertension (PH) is prevalent in hemodialysis (HD). In the general population, more women than men have PH due to left ventricular (LV) disease with preserved ejection fraction (EF). Little is known about the gender-specific prevalence of PH and associated LV abnormalities in patients with end stage renal disease (ESRD) on HD. Our aim was to evaluate gender differences and LV structural and functional changes in PH among ESRD patients on HD.

08/20/2019
Research Article

Colour keys to emotion in management of children and intellectual distraction using coloured games in dental environment for children

Rajakumar S*, Kavitha Ramar and Revanth MP

Aim and objective: Dentistry for children is not difficult but is different from what is practiced for adults. The children reacts to differently to people and places around them. Anxiety is an emotional state that helps normal individual defend themselves against a variety of threats and
Dental anxiety refers to patients specific response towards dental suitation-associated stress. So the aim is to evaluate the anxiety related management of the children using intellectual mind game of the individual.

08/22/2019
Research Article

Role of novel cardiac biomarkers for the diagnosis, risk stratifi cation, and prognostication among patients with heart failure

Miao J, Estis J, Su YR, Todd JA, Lenihan DJ

Background: Current guidelines for diagnosis and management of heart failure (HF) rely on clinical findings and natriuretic peptide values, but evidence suggests that recently identified cardiac biomarkers may aid in early detection of HF and improve risk stratification. The aim of this study was to assess the diagnostic and prognostic utility of multiple biomarkers in patients with HF and left ventricular systolic dysfunction (LVSD).

08/19/2019
Case Report

Late discover of a traumatic cardiac injury: Case report

Benlafqih C, Bouhdadi H, Bakkali A, Rhissassi J, Sayah R, et al.

Blunt chest trauma leads to a wide range of lesions, relatively minor parietal injuries to
potentially fatal cardiac lesions, making diagnosis and management difficult. The diagnosis is currently facilitated by imaging, however, these lesions may go unnoticed and be discovered late through complications.

05/03/2019
Research Article

Cytogenetic and clinical features of longlivers with osteoarthritis from Precarpathian region (West Ukraine) for 1998-2014yy

Kozovyy R, Kovalchuk L, Kitsera N

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide.
Aim of our study was to assess the clinical and the cytogenetic characteristics in longlivers with osteoarthritis from Precarpathian region (Ukraine).

08/28/2019
Review Article

Biologic therapy in severe asthma: An update

Maha A Al Ammari

Asthma is a chronic inflammatory disease of the airways characterized by airway inflammation, bronchial hyperresponsiveness, reversible airflow obstruction and recurrent symptoms. Patients often present with coughing, wheezing, dyspnea, and chest tightness, were they usually responds to the mainstay of treatment that relies on inhaled glucocorticoids (ICS), and long acting β2 agonist (LABA), along with leukotriene.

08/16/2019
Letter to the Editor

Serum MicroRNA-155 in Acute Graft-Versus-Host-Disease (aGVHD)

Yvonne A Efebera*, Amy S Ruppert, Apollinaire Ngankeu1, Sabrina Garman, Prasanthi Kumchala, Alan Howard, Steven M Devine, Parvathi Ranganathan and Ramiro Garzon

Allogeneic hematopoietic stem cell transplant (alloHSCT) is a curative treatment for many hematologic malignancies. Unfortunately, about  30-50% of all recipients undergoing alloHSCT develop acute graft-versus-host-disease (aGVHD), which is associated with high morbidity and mortality [1,2].

08/15/2019
Research Article

Discovering the right treatments for diabetes (2), blood’s pressure, and relating diseases

Al-Darraji AH

For last decades diabetes type 2, blood’s pressure (especially hypertension) and relating diseases are most serious problems for much people over the world. These diseases are not like other different diseases then for studying them very accuracy, this research choose sample from different societies a small city called “Al-Mejar Al-Kabeer” in south of Iraq.

08/13/2019
Research Article

Validation of the Omron HBP-9031C blood pressure monitor for clinics and hospitals according to the ANSI/AAMI/ ISO 81060-2:2013 protocol

Kanako Saito, Yukiko Hishiki and Hakuo Takahashi*

Objective: The present study aimed to evaluate the accuracy of the Omron HBP-9031C automated oscillometric upper-arm blood pressure (BP) measurement device for blood pressure monitoring, according to the ANSI/AAMI/ISO 81060-2:2013 protocol (ANSI/AAMI/ISO).

08/13/2019
Research Article

Assessment of the effect of cigarette smoking on the different denture base material

Ashish Pandey*, Neeraja B, Himanshu Joshi, Deepti Upadhyay and Sonam Pandey

Background: The present study was conducted to assess effect of cigarette smoking on different denture base material.

08/12/2019
Research Article

Wound architectural analysis of 1.8mm microincision cataract surgery using spectral domain OCT

de Sousa BA, Teixeira A, Salaroli C, Souza N, Gomes L

Purpose: Analyze Microincision Cataract surgery wound using Fourier-Domain optical coherence tomography.
Setting: Medical School of Medicine, Catholic University of Brasilia, Brasília, Brazil.
Design: Prospective comparative observational study

08/09/2019
Review Article

Timing of cardiac surgery and other intervention among children with congenital heart disease: A review article

Chinawa JM, Adiele KD, Chukwu BF, Onukwuli VO, Ujunwa FA, et al.

Background: Early diagnosis and improved facilities are necessary for determining the optimal timing of surgery and other interventions in children with congenital heart diseases in Nigeria. This is because late presentation, late diagnosis and delayed surgery can lead to mortality and affect the quality of life among these children.

08/16/2019
Research Article

Comparison of selected lower limb biomechanical variables between university of ibadan sportsmen with and without patellofemoral pain syndrome

Fabunmi A, Oladipupo SO

Patellofemoral pain syndrome is common among athletes who participate in jumping, running and pivoting sports. The aim of this study was to compare selected lower limb biomechanical variables between University of Ibadan students (athletes) with and without patellofemoral pain syndrome.

08/09/2019
Research Article

Assessment of shoulder pain and somatic dysfunction in young competitive swimmers: Preventive Osteopathic Manipulative Treatment

Granger F, Etevenard M, Kily JP, Garet M

Context: Shoulder pain is one of the most frequent reported complaints in intensive competitive swimming. The so-called ‘swimmers’ shoulder’ has been widely explored and has been reported sometimes without specific reference to contributing mechanisms or structures. Somatic dysfunction is defined as an impaired or altered function of related components of the somatic system and may appear in the early stage of pain feeling.
 

07/12/2019
Research Article

Nanotechnology to improve the biofouling and corrosion performance of marine paints: from lab experiments to real tests in sea

George Kordas

Nanocontainers of the type CuO, ZnO and CeMo were developed in the present work and incorporated into commercial paints. The nanocontainers were filled with bromosphaerol (CuO and ZnO), SeaNineTM 211 (CuO and ZnO), and 8Hydroxyquinoline (CeMo). The new resulting paints were tested in the lab and in the sea via painting a fraction of two ships. The outcome of this work is encouraging demonstrating that the new nanotechnology-based paints yield to superior commercial paints that may present a major milestone in the new generation of marine paints.

07/15/2019
Research Article

Research of possibilities of studying the areas of development of erosion of slope lands in Azerbaijan and fight it

Rans Aliev ZH*

The study proved that in gully systems with the largest catchment area ranging from 5.0 to 28.8 km2, the degree of dismemberment of gully systems is small, varies mainly from 1 to 3 km / km2, less often from 3 to 5 km / km2. As can be seen, the average annual growth of ravines is 0.34 ... 7.48 m in length, 0.20 ... 2.48 m in width, 0.10 ... 1.16 m in depth. The intensity of erosion development (ravine, planar, etc.) is mediated by their catchment area. Moreover, the degree of division of individual gully systems here is not dependent on their catchment area, moreover, the greatest dissection is observed in gully systems that have the smallest catchment area, which is associated with the conditions of their location.

07/27/2019
Case Report

A fatal portal vein thrombosis: A case report

Kechida M, Yahia WB, Mnari W

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematologic condition which could be revealed by deep venous thrombosis. It could be fatal unless correctly treated.

07/29/2019
Review Article

Fifth “dark” force completely change our understanding of the universe

Skopec R

For something that’s literally as old as the universe, dark matter doesn’t get much attention outside scientific circles. Maybe that’s because, other than a short-lived SyFy series and a late-period Randy Newman album, this nebulous star stuff has had a tough time breaking the pop-culture barrier. But the truth is that today, dark matter has never mattered more.

07/26/2019
Research Article

The effects of a clinical ladder program on professional development and job satisfaction of acute care nurses

Coleman YA, Desai R

Nurses play a vital role in acute care hospitals and health care delivery. The purpose of this research study is to identify the nurse’s perception of the Clinical Ladder Program at their hospital and the correlation it has on the nurse’s job satisfaction and their professional development.

07/26/2019
Review Article

Subungual exostosis: Pediatric aspects

Dendane MA, El Bakkaly A, Hassani ZA, Amrani A

Subungual exostosis (SUE) is a benign phalangeal tumor of an osteocartilaginous nature [1]. SUE is most commonly diagnosed in children and young adults; most of these lesions are located in the big toe, although they can occur (albeit infrequently) in other toes. We report five observations of SUE described in young children under 10 years and discuss the particularities of this pathology in the pediatric population.

07/24/2019
Research Article

Epidemiological Prevalence of Tuberculosis in the State of Maranhão between 2014 and 2016

Miranda Neto PAD, de Melo Santana HB, das Neves VM, Maia HS, França TMN, et al.

Introduction: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Bacillus of Koch), and presents chronic evolution affecting the lungs frequently.
Objectives: Analyse, in the state of Maranhão, the epidemiological prevalence of tuberculosis between 2014 and 2016.
Materials and Methods: Documentary and descriptive study of secondary data collected in the database of the dates, epidemiological information and morbidities, between 2014 and 2016.

07/24/2019
Research Article

The New (2018) European Hypertension Guidelines an overview & comments

Mohsen Ibrahim M*

The European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) jointly developed a series of hypertension guidelines in the years 2003, 207 and 2013. The most recent guidelines were issued by the two societies in August this year (2018) and were published in the European Heart Journal.

07/24/2019
Research Article

Rehabilitation of hearing by cochlear implantation

Raji A, Mounji H, Rochdi Y, Nouri H, Elfakiri M

Background: Cochlear implants (CI) are nowadays a widely accepted treatment for sensorineural hearing loss SNHL.
Aim: This study aimed to describe the epidemiological characteristics and the surgical approach and to evaluate the outcomes of our experience in cochlear implantation.
Setting: Department of Otolaryngology-Head and Neck Surgery of University Hospital Mohammed VI Marrakech Morocco.

07/23/2019
Research Article

Prevalence and seasonal variations of eggs of gastrointestinal nematode parasites of goats from smallholder farms in Mozambique

Atanásio-Nhacumbe A, Sitoe CF

A survey was carried out to determine the prevalence and seasonal variations of eggs of gastrointestinal nematodes in goats in four provinces of Mozambique, from November 2016 to October 2017 in Tete and Cabo Delgado, and from November 2016 to October 2018 in Maputo and Gaza. In each province, flocks were selected from both lowlands, located within the valleys of the rivers, and uplands which are located outside the valleys. Faecal samples were collected at monthly intervals to monitor faecal egg counts fluctuations.

08/08/2019
Research Article

Relation of Arachnophobia with ABO blood group system

Qadir MJ, Zahra SE

In 1901, ABO system of blood groups was determined by Karl Landsteiner. It is present in different organisms like rodents, primates that includes chimpanzees, bonobos etc. The blood groups type in this system depends on some genes that are specific ABO gene. Arachnophobia is the dread of creepy crawlies and different creature like spiders.

08/07/2019
Case Report

Daub, Discolouration, Pigmentation-Solar Lentigo

Bajaj A

Solar lentigo is defined as an alteration in cutaneous pigment deposition on account of exposure to ultraviolet radiation. Solar lentigo is a benign, pigmented lesion with a characteristic increment in the quantification of pigmented keratinocytes. It can manifest as a dark brown spot on the skin.

08/08/2019
Research Article

Prevalence of ESBL urinary tract infection in children

Awean GZA, Salameh K, Elmohamed H, Alshmayt H, Omer MRB

Urinary tract infection (UTI) is one of the extremely popular causes of febrile illness in children, demanding antimicrobial therapy [1]. Overall, 8% of females and 2% of males, experience at least one incident of UTI by seven years of age, and recurrence takes place in up to 30% during a year [2].

07/24/2019
Case Report

Severe Infantile Transaldolase deficiency: A case report

Alqoaer K, Asaad Z, Halabi M

Transaldolase TALDO deficiency is a rare autosomal recessive disorder of the pentose phosphate pathway. It has variable presentations with poor outcome when present early in life. We present a young Saudi infant with a fatal early presentation of TALD deficiency.

08/08/2019
Review Article

A Belgian program to fight child maltreatment: The “SOS children” teams

Dechêne S, de Becker E

Child abuse remains a complex issue affecting individuals, families, groups and society, and one which WHO prevalence figures show as a significant ongoing problem. The nature of the abuse, be it physical, sexual, psychological, or neglect, places the child at high risk of experiencing the multiple sequelae of the trauma.

08/06/2019
Research Article

Effectiveness of ethinyl oestradiol /cyproterone acetate and ethinyl oestradiol/ desogestrel with or without low-dose metformin on perceived health-related quality of life in hirsute women with polycystic ovary disease: A randomised, double-blind, placebo-controlled study

Fonseka S, Subhani B, Alahakoon V, Wijeyaratne CN, Gawarammana IB, et al.

Background: Polycystic ovary disease (PCOD) is an endocrine disorder. It leads to menstrual disturbances, infertility, obesity and dermatological manifestations such as hirsutism and acne which leads to impaired health-related quality of life (QOL).

08/05/2019
Case Report

Clinical, histopathological and surgical evaluations of persistent oropharyngeal membrane case in a calf

Gunes V, Atalan G, Bayram LC, Varol K, Erol H, et al.

A male, 4 days old and 20 kg Simmental calf was evaluated for regurgitation and hyper salivation since birth. The mother became pregnant by artificial insemination and the pregnancy was the second of the mother. A membrane closed the pharynx and a diverticulum on dorsal of this membrane was seen during oropharyngeal examination through inspection.

08/02/2019
Case Report

Type II myocardial infarction and latent LVOT obstruction due to Systolic Anterior Motion of mitral valve

Constantinos M

Left ventricular outflow tract obstruction is a well-recognized feature in hypertrophic cardiomyopathy but can occur in other clinical scenarios when anatomically susceptible heart is subjected to permissive physiological conditions that provoke systolic anterior motion of the mitral valve (SAM): ie, reduced preload, increased inotropic state, and decreased afterload.

08/02/2019
Research Article

Effect of Khaya Senegalensis Bark and Oil on Post-Harvest Fungal Agents of Groundnut Seeds Rot in Adamawa State, Nigeria

Channya FK, Asama P, Anjili SM

Standardized method of seed treatment is of prime importance in the production of groundnut. The study was to carry out control trial using bark extract (aqueous and ethanol) and oil (seed) of mahogany (Khaya senegalensis) on seven (7) isolated fungi from two groundnut varieties (peruvian and valencia).

08/07/2019
Research Article

Prognostic implications of vitamin D deficiency in chronic kidney disease

Martínez-López D, Jover-Ríos D, Esteve-Atiénzar P, Méndez-Mora J, Seguí- Ripoll JM, et al.

Chronic kidney disease (CKD) is a highly prevalent disease, imposing high mortality rates worldwide, and it is closely related to cardiovascular events. Vitamin D deficiency is very prevalent in patients with CKD from the earliest stages of the disease, and it has been associated with higher mortality.

07/31/2019
Research Article

Is there improvement in renal function in patients undergoing bariatric surgery?

Bezerra JAB, Brandt CT, Borborema DMB, Ramos AQ, de Souza MR, et al.

Introduction: Obesity may cause progressive chronic kidney disease. Weight loss in the postoperative follow-up of bariatric surgery may improve renal function in these patients. Thus, the purpose of this study was to give insight on the subject using a sensible biomarker.

08/01/2019
Research Article

Carbonic Anhydrase I modifies SOD1-induced motor neuron toxicity in Drosophila via ER stress pathway

Lu D, Peng X, Jia S, Li G, Tan N, et al.

Background: Drosophila models of amyotrophic lateral sclerosis (ALS) have been widely used in understanding molecular mechanisms of ALS pathogenesis as well as discovering potential targets for therapeutic drugs. Mutations in the copper/zinc superoxide dismutase (SOD1) cause ALS by gain of toxic functions and induce toxicity in fly motor neurons.

07/31/2019
Research Article

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

Luisetto M, Ahmadabadi BN, Rafa AY, Sahu RK, Cabianca L, et al.

Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and inflammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem and the process. Scope of this project is to submit to the researcher a new therapeutic strategy (under a depurative- toxicological-pharmacological) in this complex kind of disease. A Turing machine theory say us a method to TRASLATE the need of a strategy in a practical hypotesys of work. A global conceptual map can help in this field.

07/24/2019
Research Article

Comparative study of carboxylate and amide forms of HLDF-6 peptide: Neuroprotective and nootropic effects in animal models of ischemic stroke

Bogachuk AP, Storozheva ZI, Proshin AT, Sherstnev VV, Smirnova IV, et al.

Aim: The work was to perform a comparative study of the neuroprotective and nootropic activities of two pharmaceutical substances, the HLDF-6 peptide and its amide form (HLDF-6-NH2).

04/30/2019
Review Article

Sleeplessness and health

Sunitha V, Kurushev J, Chitra F, Dash M

Sleep influences each intellectual and physical health. It’s essential for a person’s well-being. The reality is when we see at well-rested people, they’re working at an exclusive degree than people making an attempt to get by way of on 1 or 2 hours much less nightly sleep.

07/31/2019
Research Article

P wave dispersion in patients with premenstrual dysphoric disorder

Yavuzkir S, Aydin S, Baspinar M, Korkmaz S, Atmaca M, et al.

Background: Growing evidence has revealed that fear and anxiety related situations could affect cardiac parameters. P wave dispersion (Pd) is an important index. In the present study, we aimed to evaluate Pd values in patients with premenstrual dysphoric disorder.

07/31/2019
Research Article

Preclinical stiff heart is a marker of cardiovascular morbimortality in apparently healthy population

Fauvel C, Bubenheim M, Raitière O, Vallet C, Bauer F, et al.

Background: The prognostic signifi cance of impaired left ventricular (LV) relaxation and increased LV stiffness as precursor of heart failure with preserved ejection fraction and death is still largely unknown in apparently healthy subjects.

07/30/2019
Case Report

Severe Infantile Coarctation and Mid Aortic Stenosis in Williams Syndrome

Lousararian M, Troglia A, Cabrera M, Alday Luis E

We report a challenging patient with Williams syndrome and severe coarctation of the aorta. As in a few similar cases reported, several surgical and catheter interventions for recoarctation, intrastent intimal proliferation and stenosis of the left sub-clavian artery were required. Aortic patch angioplasty is planned for the future in a grower child.

07/23/2019
Research Article

Longitudinal and transverse dimensions of Hypertrophied Cardiomyocytes in human Left Ventricle (LV) at autopsy; Heart failure might result from changes in chamber geometry without contractile weakening

Richard E Tracy

The shapes and sizes of human cardiomyocytes are accessible to systematic observation under most circumstances only at autopsy. This constraint has seriously curbed the study of these topics, thereby leaving a crippling gap in our understanding of heart failure. In recent years the only published ongoing findings have come from this laboratory.

07/30/2019
Research Article

Determination of anthocyanin content in two varieties of Hibiscus Sabdariffa from Selangor, Malaysia using a combination of chromatography and spectroscopy

Yew-Keong Choong*, Nor Syaidatul Akmal Mohd Yousof, Jamia Azdina Jamal and Mohd Isa Wasiman

The calyces of Hibiscus sabdariffa have been used by many communities as herbal tea. Their anthocyanin contents have been reported as the key component in anti-obesity studies. This present work reported results of anthocyanin content of calyces in two varieties of H. sabdariffa collected from Sabak Bernam, Selangor, Malaysia.

07/23/2019
Research Article

Analysis of the characteristics of chinese traditional sports culture in the new period

SC Wang

Through cultural consciousness, the characteristics of traditional Chinese sports culture in the new period are analyzed and studied, and the traditional Chinese sports culture in the new period has the following six characteristics: 1. Sports social model of “etiquette” 2. Sports personality model of the gentleman’s way; 3. The sports behavior mode of the golden mean; 4. The social nature of sports of socialism with Chinese characteristics; 5. Sports cultural nature of emotional culture; 6 limited competitive sports competition.

07/23/2019
Short Communication

Triathlon challenge – from craggy to crazzy a different kind of pain management program

Michael G Serpell

Sea swim (2.4 mile), bike ride (112 mile) and Marathon (26 mile), all in one day!
There are lessons that the 7.8 million UK Chronic Pain patients can learn from the world of endurance sports, and vice versa [1]. The training, psychological tools and strategies used by athletes to complete an endurance event, are equally relevant for those with chronic pain, who wish to regain some form of “normal” life if treatment therapies have failed [2,3].

07/22/2019
Review Article

Update on Phenobarbital for Alcohol Withdrawal Syndrome in Intensive Care

Parthvi R, Agne P

Alcohol abuse is a global health problem. Alcohol withdrawal syndrome (AWS) ranges from mild to severe symptoms that can lead to fatal delirium tremens requiring ICU admission and incurring high health care cost as high as $20,000 a month.

07/19/2019
Research Article

Causal agents of Post-harvest Rot of Pumpkin (Cucurbita pepo L.) and their control using Indigenous Practices in Hong, Adamawa State

Kazi N, Chimbekujwo IB and Anjili SM*

Pumpkins (Cucurbita pepo) are grown all around the world for a variety of reasons ranging from agricultural purposes to commercial and ornamental sales. The pathogens causing the rot of pumpkin in the world include fungi, bacteria, and viruses. The study was aim to identify fungal pathogens of pumpkin rot during storage, as well as control measures of the diseases using wood ash, mango leaf and rice chaff.

07/15/2019
Research Article

The beneficial effects of varicella zoster virus

Al-Anazi KA, Al-Anazi WK, Al-Jasser AM

Varicella zoster virus behaves differently from other herpes viruses as it differs from them in many aspects. Recently, there has been growing evidence on the beneficial effects of the virus in immune compromised hosts and these effects are translated into prolongation of survival.

07/22/2019
Research Article

ROGAVF STUDY 2019 - Relationship of HbA1C (GLYCEMIC Control) on outcomes of AV FISTULAS: A prospective observational study

Premjeet Singh*, Zainal Ariffin, Hafizan Tajri, Azim Md Idris, Lenny Suryati and Lily Sofida

Objective: The main aim of the study was to compare outcomes based on diabetic control for patients undergoing formation of a new upper limb arteriovenous fistula (AVF). Research design and methods: A prospective cohort study was performed where we obtained baseline HbA1c in 65 patients before undergoing AV fistula formation. Patients were followed up at our clinic 6 weeks after creation to assess fistula maturity.

Results: Multiple logistic regression was used to analyze the association between HbA1c status and maturity of AVF at 6 weeks after controlling for possible confounding factors such as age, sex, presence of hypertension and dyslipidaemia. Those with HbA1c less than 6.5 were 22 times likely to have maturity of AVF at 6 weeks as compared to those with HbA1c 6.5 or more (AOR = 22.65, p < 0.005).

Conclusion: Good diabetes control, reflected by an HbA1c of less than 6.5, is associated with a very high possibility of AVF maturity at 6 weeks post creation.

07/22/2019
Review Article

Idiopathic post-operative biliary duct system dilatation; potential etiology and management

Nasr MM, Nasr MM

What is called “idiopathic biliary duct system dilatation” or better to name it “un-explained biliary dilatation” is mostly following surgical procedures related to upper gastrointestinal and hepato-bilio-pancreatic systems. Having such situation, adaptive physiology of the biliary duct system has to be considered and rational has to be explained. The vast multimodal progress in techniques of investigations that has been applied on studying the hepato-bilio-pancreatic system has been utilized to clear the clinical ambiguity of biliary duct system dilatation for no logic reason but missing the correlation between both fields; the technical and the clinical ones. This clinical review is trying to fill this gap and introduce a comprehensive discussion of the subject.   Mechanical, biochemical and immune causes constitute a wide diversity of etiology related to biliary system dilatation that in some situations is really difficult to verify clinically. On the least, even we could not verify the etiology we need to identify that reaching a closed road is different than postulating suspicions that never exist. This review is a trial collecting all subject-related data that might be related to etiology mechanisms and utilize to find a correlation rationale. At some point verification of such correlation is really a far target that might be even impossible clinically with availing technical tools and hope in the future could be achieved.

07/19/2019
Review Article

Lecture: “First aid to the population for wounds during accidents, сatastrophes, natural disasters, and terrorist attacks” for Humanitarian and Technical Universities

Shapovalov KA, Shapovalova LA

1. The concept of wounds.
2. Classification of wounds.
3. Signs of wounds.
4. Factors affecting the course of the wound process.
5. Phases of the wound process.

07/17/2019
Case Report

Anasarca in a 35 year old man- A diagnostic dilemma

Okafor UH*, Okorie GO and Ede S

Anasarca is generalized swelling of the body following accumulation of fluid in the extracellular compartments. It may result from multiple aetiology mainly of renal, hepatic or cardiovascular origin. 
The aim of this case report is to highlight the challenges encountered in making diagnosis in a patient with anarsaca.

07/17/2019
Research Article

Cognition and Memory Impairment among Patients of Depression in Pakistan-The Role of Conventional and Newer Anti-Depressants

Malik M, Khan MU, Hussain A, Hashmi A

Background: Antidepressant therapy is the most adopted treatment option for depression. The evaluation of cognitive effects related to antidepressant drug use is important for better selection of antidepressant drugs that leads to improved cognitive performance and patient health related quality of life. Aim: The aim of the present study was to evaluate the effects of antidepressant drugs on cognition and memory among patients of depression in Pakistan.

07/16/2019
Research Article

Assessment of lipid and hematological profile among blood donors in European Gaza Hospital, Palestine

Tabash AM, Afana WM, Elregeb AM, Abu Eid S, Abu Mustafa AM

Background: There is an important shortage of blood in the greatest blood banks worldwide to meet up with requirements for numerous medical interventions. Limited studies have associated regular blood donation to the lowering of lipid function parameters. Assessing the lipid function is a classical method of evaluating an individual’s risk for coronary heart disease.

07/16/2019
Case Report

Single Trans apical access for double aortic and mitral valves-in-valves procedures with high risk of thrombus embolism

Adjedj J, Kirsch M, Nowacka A, Muller O

Persistent left atrial thrombus remains a contra indication to transeptal valves in valves procedure. We aimed to perform a double valves in valves replacement through transapical access with cerebral angiography control during the procedure just after implantation.

07/16/2019
Research Article

The relationship between serum and sputum levels of azithromycin and clinical endpoints in patients with bronchiectasis using azithromycin maintenance treatment

Altenburg J, Wilms EB, Boersma WG

Background: Azithromycin (AZM) is a macrolide antibiotic with distinct pharmacokinetic properties and is increasingly used as maintenance treatment in patients with bronchiectasis in order to reduce infectious exacerbations and improve pulmonary symptoms. The exact mechanism of action is not known and the relation between azithromycin dose level, local and systemic drug levels and clinical effect however, has not been extensively studied yet.

07/16/2019
Research Article

Cloning and Characterization of a Pseudo-Response Regulator 7 (PRR7) Gene from Medicago Sativa Involved In Regulating the Circadian Clock

Yilin Shen and Weifeng Nian*

The circadian clock is an endogenous molecular oscillator with a period of about 24 hours, which regulates the physiology and developmental processes of almost all higher plants. Pseudo-response regulators (PRRs) are an important part of the central clock oscillator, together with other clock genes, constituting interlinked transcriptional feedback loops, which partly influence plant growth and development.

07/12/2019
Research Article

Feasibility study on the evaluation of the effect of narrow-band CEChirp ASSR in the hearing fi eld after hearing aid in hearingimpaired children

Wang Yonghua* and Xing Shuoyao

Objective Study: Whether the narrow-band CE-Chirp ASSR test in the sound field is an objective evaluation method for the hearing aid compensation effect, and whether there is a difference in children with different hearing loss levels.

Methods: 39 children (67 ears) wearing full digital hearing aids with good rehabilitation effect and ability to cooperate with behavioral audiometry were selected. The narrow-band CE-Chirp ASSR test group in the sound field was set as the experimental group, and the sound field behavioral audiometry after hearing aid was set as the control group. According to the degree of hearing loss, it was divided into moderate hearing loss group, severe hearing loss group and extremely severe hearing loss group. The difference between test results of experimental group and control group was compared.

Results: There were no significant differences between the experimental group and the control group in the moderate hearing loss group and the extremely severe hearing loss group at 0.5, 1, 2, and 4kHz (P > 0.05). The results of the experimental group and the control group in the severe hearing loss group, There was no significant difference at 0.5, 1, 2kHz (P > 0.05), there was a significant difference at 4kHz (P < 0.05), and the mean difference was - 6.4dB HL. When the degree of hearing loss was not grouped, there was no significant difference between the experimental group and the control group at 0.5, 1, 2kHz (P > 0.05), 4kHz was significantly different (P < 0.05), and the mean difference was -3.2dB HL.

Conclusion: It is clinically feasible to evaluate the hearing aid compensation effect of the narrow-band CE-Chirp ASSR in the hearing-impaired children. The grouping according to the degree of hearing loss can be more accurate in evaluating the hearing aid compensation effect. The narrow-band CE-Chirp in the sound field of children with moderate and very severe hearing loss ASSR results can be directly used to assess the hearing aid compensation effect, while children with severe hearing loss need to apply correction values at 4kHz.

07/12/2019
Case Report

Methotrexate in management of Morbidly Adherent Placenta at Latifa Hospital, DHA, Dubai, UAE.: Case report

Fazari ABE, Aristondo MER, Azim F, Al Maamari BA, Eltayeb R.

Morbidly adherent placenta (MAP) includes the spectrum of placenta accreta, increta, and percreta. It is a major cause of obstetric hemorrhage. Caesarean section is main risk factor for MAP. Ultrasound scan is highly sensitive method for MAP diagnosis and sometime Magnetic resonance image is of choice.

07/15/2019
Review Article

Predictive vision on governance and total quality in sports

Mohamed I, Rabah A, Abdelnour H, Karim L, Riadh FM

The aim of our study is to try to give a predictive vision on governance in the field of sports in Algeria.

07/11/2019
Opinion

The science of enduring pain. What can athletes and chronic pain patients learn from each other?

Michael G Serpell

What mind strategies can an endurance athlete use to get their body that bit further or faster, to be a inisher? At "top-level" sport, some say it's all in the mind!! When we push ourselves to the limit, we experience adversity. How and if we overcome that, will deine us, and our achievements.

07/12/2019
Research Article

High water intake in preventing the risk of Uric Acid Nephrolithiasis: A systematic review and meta-analysis

Lin Z, Lieske JC, Li Y, Jayachandran M

Background: Hyperuricosuria, persistently low urinary pH, and low urinary volume are the main risk factors of uric acid nephrolithiasis. Epidemiologic studies suggest that high water intake is protective against the occurrence of symptomatic kidney stone events of all types. The objective of this systematic review and meta-analysis were to evaluate the effectiveness of increased water intake to prevent symptomatic uric acid kidney stone events.

07/11/2019
Research Article

Complications of Internal jugular catheters in haemodialysis patients at a kidney care center in Nigeria

Hughes OU, Stella A, Samuel E

Internal jugular vein catheters (IJC) is recommended as the central venous access of choice in haemodialysis patients. However it is associated with complications of variable severity.

07/11/2019
Opinion

Proposal for the elimination of allergies

Welles JF

A man I knew had an extreme allergy to poison ivy when he was a child. When he was about four-teen, he was hanging out with a group of his friends who dared him to eat some poison ivy. He did, and never got poison ivy again. Presumably, the ingestion of the allergen led to the development of immunity.

07/02/2019
Research Article

Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications

Hyánek J, Pehal F, Dryahina K, Dubská L, Míková B, et al.

Introduction: In this retrospective study, we comment on the cause and diagnostic potential of the elevated serum total cholesterol and some non-cholesterol sterols in a population of healthy pregnant women from Prague, Czech Republic.

07/05/2019
Research Article

Knowledge, perception and practices of Suez Canal University students regarding Hepatitis C Virus infection risk and means of prevention

El-Sayed H, Mehanna S, Hassan A, Sheded M, Elmaraghy N, et al.

Background: Egypt has the highest prevalence of HCV in the world as more than 10% of population suffers from HCV infection. High prevalence of HCV in Egypt represents a great risk to the whole population that requires aggressive mass awareness regarding routes of infection and
means of prevention.

07/05/2019
Research Article

Virulence Genes in Pseudomonas Aeruginosa Strains Isolated at Suez Canal University Hospitals with Respect to the Site of Infection and Antimicrobial Resistance

Elmaraghy N, Abbadi S, Elhadidi G, Hashem A, Yousef A.

Background: Pseudomonas aeruginosa is one of the top fi ve pathogens causing healthcareassociated infections. Biofi lm formation is nowadays a major problem. Aim: The aim of this study was to examine the prevalence of virulence genes in clinical isolates of Pseudomonas aeruginosa at Suez Canal University Hospitals with respect to the site of infection and microbial resistance of the strains.

07/08/2019
Research Article

Endoscopic treatment of pancreatic diseases via Duodenal Minor Papilla: 135 cases treated by Sphincterotomy, Endoscopic Pancreatic Duct Balloon Dilation (EPDBD), and Pancreatic Stenting (EPS)

Tadao Tsuji*, G Sun, A Sugiyama, Y Amano, S Mano, T Shinobi, H Tanaka, M Kubochi, K Ohishi, Y Moriya, M Ono, T Masuda, H Shinozaki, H Kaneda, H Katsura, T Mizutani, K Miura, M Katoh, K Yamafuji, K Takeshima, N Okamoto, Y Hoshino, N Tsurumi, S Hisada, J Won, T Kogiso, K Yatsuji, M Iimura, T Kakimoto and S Nyuhzuki

Treatments via the minor papilla is effective where the deep cannulation via the major papilla is impossible in such cases as [1] the Wirsung’s duct is inflammatory narrowed, bent or obstructed by impacted stones [2] pancreatic duct divisum (complete or incomplete) [3], maljunction of pancreatico-biliary union with stones [4], pancreatic stones in the Santorini’s duct. In [1,2] cases, the pancreatic juice flow via the major papilla decreases, while that of the minor papilla increases. Then the size of minor papilla and its orifice shows corresponding enlargement. This substitutional mechanism is an advantage when undertaking our new method. Since the pancreatic juice flow is maintained via the minor papilla in these cases, accurate and careful endoscopic skills are necessary to prevent pancreatitis due to the occlusion of the Santorini’s duct after this procedure. We have experienced 135 cases treated via minor papilla in these 27 years, so we would like to report about its safety and efficacy.

07/09/2019
Research Article

Blockade of the distal sciatic nerve with the patient in the supine position using a newly developed position aid with integrated ultrasound probe holder

Magunia J, Bernd HB, Schütz M

Background: We have developed a femoral supporting pad with an integrated ultrasound probe holder and examined its practical usability on patients with lower limb surgery.

07/09/2019
Research Article

The value of routine ultrasound at discharge to identify patients at risk of developing symptomatic lymphoceles after kidney transplantation: A case-cohort study

Joosten M, Poyck PP, d’Ancona FC, van der Meijden WA

Background: Ultrasound examination is frequently used to evaluate the graft after renal transplantation and to detect possible lymphoceles.
The first ultrasound scan in our hospital is normally performed on the day of discharge. We questioned whether perirenal fluid collections detected
by ultrasound examination at discharge are predictive for future symptomatic lymphoceles.

07/09/2019
Research Article

Effectiveness of dexamethasone and hyaluronidase + valerate of bethasone associated with prepucial massage in the treatment of child phimosis

da Rocha AK, Meyer KF

Introduction: The phimosis condition is characterized by the inability to retract the foreskin on the glans, making it impossible to expose them. Surgical treatment, although effective, has been questioned by the risk to which the patient is exposed. Therefore, we have opted for the use of
topical corticosteroids to resolve this pathology.

07/09/2019
Case Report

Mimicking multiple sclerosis - Ghost tumor that comes and goes in different parts of the brain without any treatment

Ching L, Yuen MH, Poon TL, Cheung FC, Ting SH, et al.

Lesions that spontaneously come and go in central nervous system without any treatment at different time points and at different locations (CNS) usually lead ones to think of the possibilities of multiple sclerosis. However, sometimes there are exceptions. Surgical biopsy remains an important tool for defi nitive diagnosis in difficult cases. We report a case of intracranial diffuse large B cell lymphoma that spontaneously disappeared without any treatment and then reappeared at different time points and different locations.

07/09/2019
Research Article

Diseases of the mental sphere revealed by the psychiatrist at contingent of patients of the consultative outpatient admission

Shapovalova LA, Shapovalov КA

Introduction: The problem of protecting and strengthening the mental health of the population is the most important task of ensuring the socioeconomic well-being of the Komi Republic (RK) as an integral part of the Russian Federation (RF), since it is a key resource for the development of a subarctic region.

07/09/2019
Research Article

Micropollutants in wastewater irrigation systems: Impacts and perspectives

Jimena Lazaro Gil*

Climate change and the increasing global population pose a severe threat to the availability of freshwater in the world. Over consumption of water and deteriorating water quality are problems that should be addressed in order to ensure water availability for the coming decades. In this context, the increasing presence of micropollutants in water has shown to cause detrimental impact on water quality, given the negative disturbances that they can cause on human health and on the environment. Thus, it is important to study and quantify the presence of micropollutants in water bodies and also in regenerated wastewater based irrigation systems.

07/04/2019
Case Report

Benzine as fire source in operation room

Cicarelli DD, Silva FC, Ricardo CM, Antunes ACM, Carmona MA, et al.

Provide a safety anesthesia to patient is only possible with the knowledge of material surrounding the operation room. Benzine is highly flammable substance and can produce several injures without the necessary care. This case describes a small fire caused by the presence of benzine in the surgical field concomitant with the use of electrocautery, which caused slight burns to the patient, but which could have been catastrophic, and proposes the use of protocols to prevent such accidents.

07/04/2019
Review Article

Let us start an epidemic by giving away kindness

Russer Y, George K

‘Patients were left in soiled sheets or sitting on commodes for hours. Some patients needing pain relief got it late or not at all.’ These were a sample of the findings in the Francis Report which revealed severe failings in patient care in the Mid Staffordshire NHS Foundation Trust in the UK. Recommendations in the Francis Report included the need to recruit compassionate staff and having compassion training for clinicians [1].

06/27/2019
Mini Review

Circulating platelet-derived vesicle in atrial fi brillation

Alexander E Berezin* and Alexander A Berezin

Platelet vesiculation is common factor contributing in coagulation and thromboembolism in patients with atrial fibrillation (AF). Platelet-derived vesicles are involved in the coagulation, thromboembolism, microvascular inflammation, arterial stiffness, vascular calcification, atherosclerotic plaque shaping and rupture, endothelial dysfunction, cardiac remodelling, and kidney dysfunction.

07/05/2019
Editorial

Varicella zoster virus: The potentially useful virus

Al-Anazi KA, Al-Jasser AM

Varicella zoster virus (VZV), a double-stranded DNA virus, is a highly contagious human neurotropic virus that belongs to the alpha group of herpes viruses [1-4]. Primary VZV infection (chickenpox) occurs in childhood then the virus becomes latent in the nerve ganglia [1,5-7].

06/27/2019
Research Article

A forensic treatment-monitoring study of an adult with attentiondefi cit disorder with hyperactivity and substance use disorder

Nielsen NP, Wiig EH

Background: The patient in this study experienced a childhood marked by confl icts within the family, physical abuse, frequent changes of school settings, truancy, and unspecifi ed learning disabilities. After leaving school at age 17, she was chronically depressed, had anger attacks, lacked motivation, refused psychological assistance, and had problems finding work.

07/02/2019
Research Article

Maternal mortality and factors affecting it, among pregnant women in Abeokuta South, Nigeria

Amoo TB, Ajayi OS

This observational study assessed the knowledge of pregnant women attending antenatal clinics at two selected hospitals in Abeokuta South, Nigeria on the causes and risk factors of maternal mortality, identifi ed barriers to knowledge acquisition, and examined the infl uence of
parity of respondents on their knowledge of factors causing maternal mortality.

07/02/2019
Case Report

Mesenteric cysts: A rare case

Asgharnia M, Rahbar T, Dalil Heirati SF

Mesenteric cysts are rare benign intra-abdominal tumors with an incidence of 1 case per 250,000 hospital admission. This lesion occurs most frequently in women in the reproductive period.The etiology of such cysts remains unknown but several theories regarding their development exist. Most of these lesions present with vague abdominal pain and nausea. Less commonly they will present with bowel obstruction due to external compression. The diagnosis of these tumors is by abdominal ultrasound or computed tomography. We report a case of Mesenteric cyst in 51-year-old female patient.

07/02/2019
Research Article

Focused Antenatal Care in urban Ghana: A qualitative study into physical accessibility of maternal health services in Kwabre East Municipality

Akowuah JA and Owusu BK

Background: Accessibility to healthcare is a major component of primary health care campaign for maintaining population health. Owing to this, the government of Ghana has instituted the free maternal care and focused antenatal care policies into the maternal health care policies to woefully
control maternal mortality, morbidity and to ensure improved access, quality and continuous ANC use among pregnant women.

07/02/2019
Research Article

Determinants of women’s perceived satisfaction on Antenatal care in urban Ghana: A cross-sectional study

Akowuah JA and Danquah BA

Despite evidence on major interventions on the uptake and scale up of interventions meant to promote maternal health care services, little is known about adequate use of such programmes in urban Ghana among reproductive aged women.

06/27/2019
Procedure

Thirteen steps for offi ce hysteroscopy with minimal discomfort

Lasmar RB, Lasmar BP

The Office hysteroscopy (OH) is a important procedure to make diagnosis and sometimes, treatment, of intrauterine pathology, without getting the patient to Operating Room. Its advantages are very well known: less costs, fast diagnosis, see and treat and several others. Its mainly difficulty is the discomfort during the procedure. To stimule to grow the number of
gynecologist to leave OR and to go to office hysteroscopy, we propose thirteen steps for office hysteroscopy with minimal discomfort.

06/20/2019
Rapid Communication

Utilization of post abortal contraceptive use and associated factors among women who came for abortion service at Debre Berhan Hospital, Debre Berhan, Ethiopia March 2019: Institution based cross sectional study

Muche A, Bewket B, Ayalew E, Demeke E

Background: Post abortion family planning (PAFP) is the initiation and use of family planning methods immediately after, and within 48 hours of an abortion, before fertility returns. In most women fertility returns on average about two weeks after an abortion; however, ovulation can
occur as early as 11 days post-abortion.

07/04/2019
Research Article

Non-chemical control of Armillaria mellea infection of Prunus persica

Jim Downer* and Ben Faber

Peaches, Prunus persica were planted as grafted saplings in an avocado orchard previously infested with Armillaria mellea (Vahl) P.Kumm. Trees were planted in large or small holes with or without fresh yardwaste chips added as an amendment and with or without a Trichoderma biocontrol product sprayed into the hole. Trees were monitored for six years -- growth and mortality was tabulated.

07/21/2019
Case Report

Glomus Tumor of the Scrotum: A Case Report

Legg S

Glomus tumors are rare, usually benign, lesions that arise most often in the
extremities. They are derived from the glomus body and have a propensity to be found in the fingers and toes, and often in the subungual area [1]. They typically demonstrate pinprick sensitivity, cold hypersensitivity and paroxysmal pain [2]. Only two glomus tumors of the scrotum have been reported and we report a third case of this rare tumor.

07/02/2019
Research Article

Insilico investigation of TNFSF10 signaling cascade in ovarian serous cystadenocarcinoma

Tayyeb A, Shah ZA

The ovarian serous Cystadenocarcinoma shared large number of deaths in gynecologic carcinoma. It has various numbers of molecular events from initiation to progression and at advance stage, surgery is the end product of such molecular signaling. We assess in this study the whole mechanistic view of TNFSF10 network which has the ideal apoptotic causing identity.

07/01/2019
Review Article

Cardiomyopathies - The special entity of myocarditis and infl ammatory cardiomyopathy

Escher F, Kühl U, Lassner D, Schultheiss HP

Cardiomyopathy is a heart muscle disease with structural and functional myocardial abnormalities in the absence of coronary artery disease, hypertension, valvular disease, and congenital heart disease. However, it has become clear that diverse etiologies and clinical manifestations (e.g. arrhythmogenic right-ventricular cardiomyopathy/dysplasia (ARVC/D), ARVD/C, left-ventricular non-compaction cardiomyopathy (LVNC)) are responsible for the clinical picture of dilated cardiomyopathy (DCM).

06/27/2019
Research Article

C-reactive protein is associated with ventricular repolarization dispersion among patients with metabolic syndrome

Jani Y, Rexhepi A, Pocesta B, Kamberi A, Ferati F, et al.

Background: An increasing body of evidence indicates that inflammatory activation profoundly impacts the electrophysiological properties of cardiomyocytes. A marker of systemic inflammation such as C-reactive
protein(CRP), is associated with all parameters of the Mtabolic syndrome(MetS) and that may result in adverse cardiac events via multiple effects, ultimately resulting in a prolongation of Action Potential duration (APD), and thereby of the QTC (QT corrected) interval on ECG.

06/20/2019
Case Report

Acute viral myocarditis due to Influenza H3N2 infection resembling an acute coronary syndrome: A case report

Rodriguez-Zuñiga CJ, Martínez-Ramírez L, Guizar-Sanchez CA, Trejo-Mondragon MQ, Espinola- Zavaleta N.

A 16-year-old man with history of two weeks-flu like symptoms with intermittent fever. He came to the emergency department with 2 hours-chest pain that radiates to the back and upper extremities. At the admission he was hemodynamically stable with normal blood pressure The ECG showed sinus rhythm and ST segment elevation of 0.5 mV in all leads (Figure 1A).

06/21/2019
Research Article

Bone marrow histology in CALR mutated thrombocythemia and myelofi brosis: results from two cross sectional studies in 70 newly diagnosed JAK2/MPL wild type thrombocythemia patients

Jan Jacques Michiels*, Yonggoo Kim, Myungshin Kim, Francisca Valster, Vincent Potters, Zwi Berneman, Alain Gadisseur, Wilfried Schroyens and Hendrik De Raeve

The clinical phenotypes in 268 JAK2V617F mutated MPN patients in the Seoul study were PV in 101, ET in 95 and MF in 78 and 56 CALR mutated MPN consisted of PV in none, ET in 40 and MF in 16 cases. CALR mutated MPN patients were younger than JAK2V617F mutated MPN patients (mean ages 57.5 and 66 years), had lower values for values for leukocytes (8.6 vs 11.9x109/L) and higher values for platelets (898 vs 643x109/L respectively).

06/27/2019
Review Article

Altitude sickness and Antarctic polar plateau: A review

Mishra KP, Singh SB

Antarctica is known for its extreme environmental conditions. It is the best model to study multiple stress factors at a time on human physiological responses. Although the coastal Antarctica is on Sea level but the Antarctic plateau or pole at high altitude. Since Antarctica is also becoming tourist site it is pertinent to have a proper understanding of altitude induced illnesses. In this review we have described the human acclimatization process at high altitude of Antarctic polar plateu and South Pole. The review also highlighted the symptoms, clinical features and prevention of altitude induced diseases.

06/27/2019
Research Article

Alternate day outpatient hemodialysis schedule is the appropriate practical alternative schedule to improve patients’ outcomes

Nasrulla Abutaleb*

The rise in all-cause and cardiovascular mortality and hospitalization rates among the hemodialysis (HD) patients after the long weekly inter-dialysis interval is very impressive. In fact, there is an additional long-term morbidity risk besides this acute rise in mortality and hospitalizations that can be expected from the weakly exaggerated pre-dialysis peaks of the less risky hemodynamic and biochemical parameters.

Research Article

Causes of hospital admission of chronic kidney disease patient in a tertiary kidney care hospital

Imtiaz S, Qureshi R, Hamid A, Salman B, Drohlia MF, et al.

Background: Patients with chronic kidney disease (CKD) are at the risk of increase hospital admission as compared to the general population, due to various reasons. They have increased vulnerability to cardiovascular diseases (CVD) as well as infections, therefore they usually got admit in health care units due to various reasons. The causes of hospitalization in CKD patients in this part of the world are not studied well.

06/27/2019
Review Article

Possible links between consumption of A1 “like” milk And Type 1 Diabetes (T1D)

Mohammad Raies Ul Haq, Asima H, Aarif B

During the last three decades, there has been an interesting debate on the intake of A1 ‘like” milk and incidence of type 1 diabetes (T1D) in genetically predisposed individuals. The epidemiological, ecological and case-control studies have concrete pieces of evidences in favor of the hypothesis that is further supported by animal trials in mice and rat and in vitro trials on cell lines.

06/28/2019
Short Communication

Nanotherapeutic agent for cancer: Miracle or catastrophe

Archna Dhasmana*

Nanotechnology is a smart technology in the field of biomedical engineering used for the diagnosis and treatment of diseases. Nanodrugs provide better encapsulation of drug and efficiency at low dosage to kill the targeted tissue/cells. However, the chances of chronic toxicity and high cost of treatment limits its applicability [1]. To overcome these problems still, the experts of the scientific community have been working on it, to design the best one and cost-effective treatment for the human welfare.

06/25/2019
Review Article

Connected Health Apps and Devices: Implications for Healthcare Delivery

Figge H, Kvedar JC

Healthcare is realizing the importance of health information technology - its applications and devices in play today. Advancing healthcare best practices will rely on up to date data and analysis to provide the most effective forms of therapy. Healthcare is becoming more reliant on patients who are engaging in their own healthcare. With this we are seeing an increase in available health related apps for these devices.

06/17/2019
Review Article

Utilizing Pulsed Electromagnetic Field (PEMF) Therapy (Diapulse®) for Drug- Free Pain Management to Eliminate Reliance on Opioids for Non-Malignant Chronic Pain: A literature Review and Proposal for Pilot Study

Thomas A Sharon

The Federal and State governments have declared the presence of an opioid addiction pandemic in the United States claiming the lives of more than 55,000 in 2015 (Rudd RA, Seth P, David F and Scholl L. 2016). The pharmaceutical manufacturers of the numerous FDA-approved opioid
drugs are raking in more than $5 billion per year with about 2 million chronic pain sufferers addicted.

06/13/2019
Short Communication

Not-motorized Implantable Cardiac Assistance (NICA): Hemodynamic concepts and clinical perspectives

Caimmi P, Martinelli GL, Barbieri G

The considerable improvements in cardiac support systems technologies have not solved until now the problem of connecting the cardiac assistance devices (CAD) to external energy sources, which makes these Patients at risk of lethal infections and dependent on external batteries with few hours of autonomy. Authors illustrate and discuss the hemodynamic concepts and clinical that underlie the mechanics of the first not-motorized implantable cardiac assistance device (NICA).

06/18/2019
Review Article

Trans-abdominal cervical cerclage revisited

Svigos J

Changes in contemporary obstetric and gynaecological practice in relation to ultrasound cervical screening during pregnancy, the treatment of intra-epithelial cervical neoplasia and laparoscopic surgery have resulted in an increased utilization of trans-abdominal cervico-isthmic cerclage in an attempt to reduce the incidence of mid-trimester and early preterm birth in women with repeated pregnancy loss.

06/12/2019
Research Article

Biodegradation of waste streams containing benzene, toluene, ethylbenzene and xylene (BTEX): Practical implications and brief perspectives

Srishti Singh*

Benzene (B), toluene (T), ethylbenzene (E) and xylene (X), collectively named as BTEX are mono-aromatic ring compounds with a 6-carbon benzene ring. Due to the presence of the aromatic ring, these compounds, especially benzene, are generally considered to be non-reactive species [1]. However, they are known to undergo hydrogenation and certain substitution reaction depending on the prevailing environmental conditions. Their solubility in water is usually low (i.e. relatively hydrophobic in nature) due to the low octanol-water partition coefficient (Kow) values which favour hydrophilic dissolution [2]. BTEX compounds are relatively insoluble in water and in some situations, their levels have been recorded at up to 1000 mg/L, which is much higher than the allowed maximum contaminant level of 0.005 mg/L for B, 1 mg/L for T, 0.7 mg/L for E, and a total of 10 mg/L for all three forms of X [3]. They are released into the natural environment (air, water, soil and sediments) due to landfill leaching, underground storage tanks, accidents during oil transportation and pipeline leakage from petroleum and chemical industries [4].

06/11/2019
Review Article

Stoichiometric approach to redox back titrations in ethanol analyses

Anna M Michałowska-Kaczmarczyk and Tadeusz Michałowski*

This article refers to calculations involved with determination of ethanol, analyzed according to redox back titration principle. A quantitative reasoning, based on logical sequence of statements, is presented for derivation of the formulas required to calculate the results of chemical analyses according to stoichiometric principles. The titrations are considered as two-step analytical procedures. This way, one can gain an insight into a classical redox titration and get a knowledge on the advantages of back titrations.

06/05/2019
Review Article

Host biomarkers for early diagnosis of infectious diseases: A comprehensive review

Chakraborty A, Monica S

Biomarkers have been used in the diagnosis of disease and other conditions for many decades. There are diverse ranges of analytical targets, including metabolites, nucleic acids and proteins were used as a biomarker. Clinical diagnoses already rely heavily on these for patient disease classification, management, and informing treatment and care pathways.

06/04/2019
Research Article

Correlation between mandibular condylar position and clinical dysfunction index after bilateral sagittal split osteotomies

Kalach Mussali AJ, Gonzalez-Magana F, Malagon Hidalgo HO

Several articles have discussed mandibular condyle position after bilateral sagittal split osteotomies (BSSO). However, previous studies have sought to establish a relationship between orthognathic surgery and the improvement of temporomandibular joint (TMJ) signs and symptoms.

05/31/2019
Research Article

Urinary NGAL incorporation into Renal Angina Index for early detection of acute kidney injury in critically ill children

Abu Zeid AM, Mohammed DY, AbdAlazeem AS, Mohammed Seddeeq ASE Elnaany AM

Background and objectives: New AKI biomarkers (on the top of it NGAL biomarker) have demonstrated better performance for prediction of AKI in critically ill patients with heterogeneous illness. Renal angina index was recently reported to enhance prediction of severe AKI at the time of intensive care unit admission. This study tested the hypothesis that incorporation of uNGAL in patients with renal angina improves the prediction of severe AKI.

06/07/2019
Research Article

Transcatheter Arterial Embolization for the treatment of upper gastrointestinal bleeding

Mohammed Habib* and Majed Alshounat

Background: Transcatheter arterial embolization can be used for patients with recurrent bleeding from the upper gastrointestinal tract after failed endoscopic treatment. Our aim to identify the clinical and technical factors that influenced the outcome of transcatheter embolization for therapy of upper gastrointestinal bleeding after failed surgery or after failed endoscopic treatment in high risk surgical patients.

Methods: We performed a prospective study to analysis of the 15 patients who underwent Transcatheter arterial embolization for nonvariceal upper gastrointestinal bleeding at Alshifa hospital from January 2015 to March 2019.

The following variables were recorded: demographic data, time from bleeding start to TAE, units of packed red cells before TAE and units of packed plasma before Transcatheter arterial embolization and we analysis 30 days rebleeding rates and mortality

Results: Patients treated with Transcatheter arterial embolization (median age: 62 years, range: 14–79 years).The technical success rate of the embolization procedure was 100%. Time from bleeding start to TAE was 2.1 (1-4) days , units of packed red cells before Transcatheter arterial embolization was 12.8 (4-22) packed and units of packed plasma was 3.2 (2-5) packed. Following 30 days after embolization, 2 (13%) patients had repeated bleeding and 3 (20.0%) patients died.

Conclusion: In our experience, arterial embolization is a safe and effective treatment method for upper gastrointestinal bleeding and a possible alternative to surgery for high-risk patients.

06/04/2019
Review Article

A few observations of clinical importance

Kader SA

This article reflects the opinion on a few of my clinical experiences involving symptoms and signs which are not mentioned in standard textbooks on medicine or clinical methods. These are clinical and a few radiological signs which I think worth discussing by clinical community, includes Muslim prayer’s feet, hyponatraemic bullae, early signs of oedema, PCV sign, hemi-semi-Hoffman’s sign and a few more.

06/05/2019
Research Article

Radiofrequency ablation for snoring and sleep apnoea

Neha S

Radiofrequency proves to be a useful tool for snoring/ sleep apnoea cases. Its advantage includes relative precision in incision making, relative bloodless fields if used appropriately, decrease postoperative pain and excellent healing with fibrosis which aids in stiffening tissues.

05/15/2019
Case Report

Autoimmune encephalitis associated with an ovarian teratoma in a 29-year old woman

Plaikner A, Jacob A, Rother J, Kohler C.

NMDA receptor encephalitis is a rare disease first described in 2007. Anti-NMDA receptor encephalitis affects mostly young women as neoplasms, mostly ovarian teratomas, are the underlying cause. The disease is caused by antibodies binding to extracellular epitopes of neuronal cell-surface, which leads to an internalization of NMDA-receptors. The characteristic syndrome of patients with anti-NMDAR as well as its recovery follows a certain pattern. Treatment includes
immunotherapy and removal of the immunologic trigger. This case report describes a young woman with anti-NMDA receptor encephalitis caused by an ovarian teratoma.

06/04/2019
Case Report

Brachial pseudoaneurysm associated with median nerve injury as a complication of peripherally inserted central catheter: A case report

Kauffman P, Helito AS, Poltronieri MJA, Garcia MR, Viana PCC

Introduction: Peripherally inserted central venous catheters (PICCs) have been increasingly used as an alternative to conventional central venous catheters for long-term administration of chemotherapy, antibiotics, parenteral nutrition, and hydration in patients with difficult venous
access. Traumatic complications to arteries and nerves adjacent to veins selected for PICC placement have been rarely described.

05/14/2019
Research Article

Frequency of cytomegalovirus infection in children with Nephrotic Syndrome

Youssef DM, Mohammed MH, EL-Behaidy EM, Abo-Warda AE

Introduction and aim: Idiopathic nephrotic syndrome (INS) is the most common type of this disease during childhood. Minimal change nephrotic syndrome (MCNS) is the most common histopathological lesion (80 – 90%) of INS in children and about 90% of patients are steroid responsive, while congenital nephrotic syndrome is disorder that may be caused by several diseases.

06/07/2019
Research Article

Transcatheter embolization of congenital vascular malformations, single center experience

Habib M, Alshounat M.

Background: Congenital Vascular malformation relatively rare and extremely varied clinical presentations. The purpose of our study was to present our initial experience of embolization in a series of 26 patients with congenital vascular malformation to assess retrospectively the results and the complications of ethanol and coils embolization treatment of these patients.

06/04/2019
Case Report

Eosinophilic otitis media and eosinophilic asthma: Shared pathophysiology and response to anti-IL5

Drijver-Messelink MT, Wagenaar M, van der Meij J, ten Brinke A

Asthma is a highly prevalent airway disease with multiple phenotypes [1,2]. Adult-onset eosinophilic asthma is a severe asthma subtype associated with more frequent and severe exacerbations, the development of persistent airflow limitation and a poorer quality of life. This type of asthma is much more difficult to control than other asthma subtypes, requiring high doses of inhaled or even oral corticosteroids (OCS) [3,4].

06/04/2019
Research Article

Assessing the stand size of bay trees (Persea spp.) after exposure to laurel wilt disease in a North Florida Preserve

Anthony M Rossi* and Christopher Bentzien

Although laurel wilt disease was first reported in the United States in 2002 from redbay trees (Persea borbonia) around Savannah, Georgia it has rapidly spread throughout the southeastern coastal plain including Georgia and Florida. In the current study, transects were used to assess the spread and impact of the disease on two native bay trees redbay (P. borbonia) and swampbay (P. palustris) from north Florida in a semi-naturalized ecological preserve.

05/27/2019
Research Article

Investigation and analysis of fracture failure and fatigue cracking in Highrise pavement using simulation software of ABAQUS

Seyed Masoud Hadian*

Assuming that the road infrastructure has been implemented in accordance with specifications and standards, poor adhesion between the two layers of asphalt mix can be a significant cause of pavement problems. The general problem observed with the weak adhesion between the layers is the slip failure. Slipping disruption in areas where transport acceleration increases, in areas where acceleration decreases or may occur in bumps. One of the criteria and a test method for measuring adhesion resistance between the hot mix asphalt layers is needed to improve the surface finish. The main objective of this study is to determine the effect of reducing the coefficient of friction between asphalt layers in the displacement of asphaltic layers. Because performing experimental experiments in the country is a deterrent to this goal, the use of analytical and numerical methods has been shown to play an important role in conducting studies. Therefore, in this paper, using vehicle simulation in ABAQUS software and analyzes, it has been found that decreasing the coefficient of friction (adhesion reduction) increases the interlayer deformation, which causes the surface of the pavement to fail. Three different thicknesses for asphalt cladding, including 4, 6, and 7 centimeters, and three different thicknesses for roller concrete layers of 18, 20 and 22 centimeters are used. Modeling and analysis of pavements with finite element method has been performed and the depth of the asphalt and tensile strain slope is calculated at the maximum level. The results show that the type of asphalt mix has a high impact on the amount of sloping and tensile strain at the maximum level. So that under different conditions it is estimated to be about 2-3 times in the amount of rotation at the surface. Also, the amount of groove and strain in the middle of the procedure is increased by a thickness of 11% the thickness of the roller concrete thickness has not changed, but the surface strain has been reduced by 9%.

06/07/2019
Research Article

Impact of the Israeli attacks at 2014 on incidence of STEMI in Gaza

Habib M, Aldabbour B

For 51 days, Gaza was pummeled down by the Israeli military in a war known as Operation Protective Edge. During the 50 days (7-7-204 to 28-8-2014) of the Israeli campaign, 2104 Palestinians were killed, including 253 women (12%) and 495 children (24%). According to the UN, at least 69% of Palestinians killed were civilians. It is estimated that 10,224 Palestinians, including 3,106 children (30%) and 1,970 women (19%) were injured.

06/04/2019
Research Article

Single-centre real world experience of the Mynx Femoral closure device in patients undergoing percutaneous coronary intervention

Thirunavukarasu S, Zaman M, Hayat A, Aghamohammadzadeh R, Malik N.

Background: Vascular closure devices are routinely used following femoral artery access to perform percutaneous coronary interventions (PCI). A number of devices are available on the market. We have reported previously on our experience of the Mynx device following diagnostic coronary angiography.

06/03/2019
Case Report

Massive gastrointestinal bleeding; never too old to be due to Meckel’s Diverticulum - A case report and literature review

Mansour S, Halloun K, Khuri S

Gastrointestinal (GI) bleeding is a very common medical problem encountered in the acute care setting, and is a major cause of admission to hospitals with about 300,000 patients admitted annually. Obscure GI bleeding, defined as persistent or recurrent bleeding following initial negative upper and lower endoscopy, represents approximately 5% of all GI hemorrhages.

06/05/2019
Research Article

Knowledge and views about coordinated individual planning from the perspective of active older adults

Jobe I, Engstrom A, Lindberg B

Background: Today’s older adults are often well informed and want to participate in decision-making processes. The coordinated individual planning process offers them active involvement in deciding and owning how their care will be managed.

05/15/2019
Research Article

Asynchronous flowering in clonal seed orchards - An effective strategy for alternative management

Soma Mondal*, Ashutosh Srivastava, Geeta Joshi and HC Yashavantha Rao

Tropical forests have long been of interest to biologists because of their high species diversity and their complicated patterns of community organization. The recent ecological studies which have demonstrated that tropical trees are diverse in their reproductive biology and dynamic population structure.

05/23/2019
Research Article

Postural and Kynematic effect of a new custom-made foot insole called “Prodynamic” in a cohort of patients affected by extrapiramidal disease

Falso M, Grillo M, Righetti A, Lopa F, Rocco L, et al.

Background: The use of a custom-made orthotic plantar device is referenced as a true sensor-motor facilitation tool for the control of the postural orthostatic and orthodynamic position in patients with Parkinson’s
disease.

05/22/2019
Research Article

Kinesio taping in patients with shoulder impingement

Sorin P, Ramirez FJ, Joly A, Patiño O Terrasa S

Study Design: Prospective Observational Study

Background: Physical therapy is one of the primary treatment options for these patients, however, we were unable to identify previously published research that objectively assesses the impact of taping on joint range of motion or on pain levels in patients with SAIS. This gap in the
literature motivated the present study.

04/23/2019
Research Article

Effectiveness of therapeutic ultrasound and kinesio tape in treatment of tennis elbow

Shaheen H, Alarab A, Ahmad MS

Objective: To investigate the effect of kinesio tape and therapeutic ultrasound on pain and hand grip strength associated with tennis elbow.

05/13/2019
Case Report

The forgotten player in the surgical history

Yves Cirotteau*

The research concerning a preventive treatment of an osteoporitic femoral neck fracture started in 1990 because the surgical procedure of unstable femoral neck fractures is difficult. After effects are frequent and
their number will increase in the next decade. The goal is to reinforce the femur with a biomaterial acting as a bone graft.

04/17/2019
Research Article

The PVSG/WHO versus the Rotterdam European clinical, molecular and pathological diagnostic criteria for the classification of myeloproliferative disorders and myeloproliferative neoplasms (MPD/MPN): From Dameshek to Georgii, Vainchenker and Michiels 1950-2018

Jan Jacques Michiels* and Hendrik De Raeve

The present article extends the PVSG-WHO criteria into a simplified set of Rotterdam and European Clinical, Molecular and Pathological (RCP/ECMP) criteria to diagnose and classify the myeloproliferative neoplasms (MPNs). The crude WHO criteria still miss the masked and
early stages of ET and PV.

04/15/2019
Research Article

Primary myelofibrosis is not primary anymore since the discovery of MPL515 and CALR mutations as driver causes of mono-linear megakaryocytic and dual megakaryocytic granulocytic myeloproliferation and secondary myelofibrosis

Jan Jacques Michiels* and Hendrik De Raeve

Primary myelofibrosis (PMF) is a distinct clinicopathological myeloproliferatve disease (MPD) not preceded by any other MPD ET, PV, CML, or MDS. With the advent of the MPL515, CALR and
JAK2V617F mutations as the driver causes of three variants of ET (thrombocythemias) the term ET is not essential and PMF is not primary anymore simple because myelofi brosis is a secondary event in all three molecular variants of thrombocythemia and PV

04/25/2019
Mini Review

Handwashing in healthcare today: Why haven’t we gotten better?

Carte NS

In 2010, a study identified that only about 40 percent of doctors and other health care providers comply with proper hand hygiene techniques in hospitals and other healthcare facilities. These statistics are alarming as healthcare professionals are the ones who set the gold standard for hygiene and sterility, but they continue to find it difficult to demonstrate this standard in every practice [1].

04/26/2019
Case Report

An uncommon cause of isolated ascites: Pseudomyxoma peritonei

Louly Hady*, I Nassar, K Znati and N Kabbaj

Pseudomyxoma peritonei or Gelatinous Peritoneal Disease is a rare disease. We report a case treated in the department of Hepato-Gastroenterology at Ibn Sina Hospital in Rabat, of a 64-year-old male who presented with an abdominal pain and an increased volume of the abdomen corresponding to ascites. Imaging and anatomopathological study made it possible to diagnose the disease. However, given the general state of the patient, he is under palliative care.

05/07/2019
Case Report

A successful case report in woman: A gender medicine?

Laviscio E, Ciarambino T, Imbriani A, Giordano M, Topo F

Introduction: Abdominal hernia is a pathological condition resulting from abnormal protrusion of abdominal viscera. In particular, internal hernias (IH) represents about 0.2-0.9% of all cases with para- duodenal hernias while obturator hernias accounting for only 0.07% of all hernias.

Methods: We reported the case report of 79 year old women who was admitted to Internal Medicine Department of our Hospital for lung failure and after few days transferred to our Surgery Department for abdominal pain.

Conclusion: Obturator hernia is rare type of hernia and it is more frequent in older women with history of multiple pregnancy, chronic cough, and habitual constipation. In our patients, detailed physical examination and MRI preoperative imaging studies, have induce to the successful diagnosis.

05/02/2019
Research Article

A model of the 2014 Ebola virus: Evidence of West Africa

Nadhem Selmi

Outbreaks of Ebola virus can cause substantial mortality in affected countries. The largest outbreak of Ebola to date is currently underway in West Africa, with 3944 cases reported as of September 5, 2014. For the sake of deriving a better understanding of the Ebola transmission
dynamics, we have undertaken to revisit data from the initial spark of origin of the Ebola virus, which occurred in 1976 in Zaire (now Democratic Republic of Congo). By fi tting a mathematical
process to time series stratifi ed by disease onset, outcome and source of infection, we have managed to estimate several epidemiological quantities, previously admitted to be too challenging to measure, including hospital and infected community contribution infection to the widespread transmission.

04/19/2019
Research Article

Determine seroprevalence and associated risk factors of HBV infection among pregnant women and it relationship with blood transfusion at Hargeisa Group Hospital, Hargeisa, Somaliland

Al-Mamari A.

Background: The measures are being put in place for the management of Hepatitis B virus (HBV) infection in Hargeisa, Somaliland among pregnant women remain the most vulnerable to develop chronic hepatitis. Routine screening in pregnant women is therefore necessary for
effective control.

05/08/2019
Review Article

Pharmacodynamics of cannabinoids

Sulcova A

“Pharmacodynamics of cannabinoids “(i.e. a set of biological effects elicited in the living organism by interaction with its biochemical and biophysical functions up to the cellular level) is studied for a long time during both, physiological and pathological conditions.

05/14/2019
Case Report

Hypertriglyceridemia induced acute pancreatitis in pregnancy: Learning experiences and challenges of a Case report

Athar S, Ramawat J, Aziz MA, Boama V

Hyperglyceridemia induced pancreatitis in pregnancy accounts for 4% of all cases of acute pancreatitis. Though rare, hypertriglyceridemia induced pancreatitis may lead to fatal maternal and fetal complications, even maternal death. Its management during pregnancy remains a
challenge for many physicians. Management options are limited in pregnancy. In the refractory cases, management options and timing of delivery is debatable. Here we report a case of hyperglyceridemia induced pancreatitis and the challenges faced in the management.

05/09/2019
Case Report

Giant cellular angiofi broma of the vulva: case report

Ribeiro A, Ferreira I, Ramos

Cellular Angiofibroma is a rare benign mesenchymal tumor without gender preference. It is usually a small (<3cm), well-circumscribed, mostly asymptomatic and typically slow growing. Surgical removal of the mass with its capsule is the preferred treatment, not only helps guarantee complete excision and prevent its recurrence but also minimize blood loss. We present the case of a 76-year-old woman with a giant vulvar mass

04/23/2019
Research Article

Demographic survey and management outcome of Post-Neonatal Tetanus at the Ekiti state university teaching hospital, Ado Ekiti

Ajite AB*, Ogundare EO, Oluwayemi IO, Olatunya OS, Babatola A, Taiwo A, Komolafe A and Fatunla O

Background: Tetanus continues to threaten the survival of children in spite of it being a vaccine preventable disease. The objective of this study was to determine the prevalence of post-neonatal tetanus, review the vaccination of affected children, complications encountered and the outcome among affected children in a tertiary health institution in southwestern Nigeria.

05/09/2019
Mini Review

An analysis of wild animals with respect to French Ethics and Law

Nouet JC, Brigaudeau J

Before discussing the crux of the matter, it is important to understand what “wild” signifies and the characteristics that define a wild animal.
 

05/07/2019
Research Article

Medical coverage of the 29th “Tour du Faso”

Cisse AR, Hope JMV, Ba A

Purpose: Medical coverage of the 29th “Tour du Faso” primarily aimed to report the experience of the medical coverage of the 2016 International Cycling Tour of Burkina Faso.
Methods: This is a prospective study of the medical coverage of the 2016 International Cycling Tour of Burkina Faso.
Results: During the 12 days of medical coverage, 216 consultations were recorded. The complaints were diversified. From simple asthenia to severe malaria. There were cases of indigestion, gastroenteritis and food allergies.
Conclusion: The medical coverage of a cycling competition requires knowledge of the discipline, expertise in sport and emergency medicine.

04/29/2019
Research Article

Head impact exposure comparison between male and female amateur rugby league participants measured with an instrumented patch

King DA, Hume PA, Cummins C, Clark T, Gissane C, et al.

Background: Epidemiological studies report that females experience greater rates of concussion when compared with males. Biomechanical factors may result in greater post-impact head velocities and accelerations for a given force for females when compared with males.

05/08/2019
Research Article

Is secondary prevention information before discharge adequate after percutaneous coronary intervention?

Henriksson C, Perk J

Introduction: Implementation of prevention strategies for patients with coronary artery disease (CAD) is essential, but many fall short of reaching their goals. Patients often perceive themselves as healthy and are less motivated to change lifestyle. To obtain better results patients need repeated information, preferably with motivational and person-centered approaches.

04/25/2019
Research Article

A qualitative method for determining the surfaces between asphalt layers using ABAQUS software

Seyed Masoud Hadian*

The analytical models are mainly combined with numerical equations for the problems of the pavement under the wheel load. Different assumptions can be considered, such as elastic asphalt and viscoelastic as well as static or dynamic load. Mainly on deformation at the bottom of asphalt and tension layers focus on subgrid. The pavement structure was considered as layers with uniform characteristics. Therefore, this analytical model calculates the three-dimensional contact tension between the wheel and the pavement and the shape of the contact area. Basis and subgrid are considered linear and the asphalt layers can be linear or viscoelastic. This model is based on the results of direct shear stress tests at an axial load constant. The curves obtained from this experiment can be defined by three parameters: the maximum shear stress (shear stress curve versus shear displacement), the interaction modulus between the layers (the same curve slope) and the friction coefficient after the failure. Due to the ability of ABACOUS software, this project is done with this software. One of the methods widely used to predict viscoelastic responses of asphalt mixtures is the finite element method. ABAQUS software is one of the tools that can simulate mixed asphalt behavior based on a finite element method, taking into account all the determinant parameters. The use of the Prony series is one of the common techniques for describing the viscoelastic behavior of asphalt mixtures in ABAQUS software. For this purpose, it is necessary to determine the parameters required for this field, including proven constants, moment elastic modulus, and asphalt mixture poison ratio. On the other hand, the determination of these parameters through testing in addition to spending time and costs requires laboratory equipment. Therefore, in this thesis, a three-dimensional finite element model with ABAQUS software was constructed to analyze the persistent pavement using theoretical relations without conducting the experiment. Also, viscoelastic behavior of common asphalt mixtures and time dependence of its responses at different temperatures can be modeled in ABAQUS software. After performing the shear stress test for different axial loads, different temperatures, with or without a single coil, they found that all parameters are temperature dependent and the coefficient of friction does not depend on the applied axial load. This new model improves the accuracy of the finite element model and its important role can be an analytic expression that includes all the variables that are effective in the problem.

04/16/2019
Research Article

Study the effect of transient vibration on multi-storey building structure according to equivalent spring-mass system performed by Ansys

Dinesh Sen and Anosh Kujur*

The carried work has based on transient vibration response of multiple degrees of freedom (MDOF) system. By this work study of Time–history analysis and prediction of the displacement for excitation has done. For the MDOF system, we have taken the four-storey building to done transient vibration. We establish the equivalent spring-mass system. Transient analysis has done for both Undamped and Damped of the forced system of multiple degrees of freedom (MDOF) system. In the case of the Damped system, we have done three stages of damping, i.e., (1) Underdamped system, (2) Critically damped system, (3) Overdamped system. The time-history graph obtained for two different time stages i.e. 0.001 sec & 0.01 sec with initial time 0.000001 sec. The natural frequency has determined by both theoretical calculation and ANSYS. The whole study of transient vibration makes it possible to predict the damping values that oppose any kind of sudden impact or force vibration, such as blasts, earthquakes and tsunamis. The ANSYS is the modelling and simulation software is used to perform the transient vibration response. The Mode Superposition method is used by ANSYS to calculate the structure response.

05/02/2019
Research Article

Prevalence of premarital sexual practice and associated factors among Goba town high school students, Southeast Ethiopia

Hagisso SN, Handiso TB

Background: Premarital sexual practice signifi cantly attributes for increase adolescent’s risk of unintended pregnancy, early marriage, abortion and STIs. In Ethiopia adolescents were intended to engage at early initiation to sexual intercourse without having proper protection has been one of the concerns. Study aimed to assess the prevalence of premarital sexual practice and associated factors among high school students.

05/03/2019
Case Report

Reversal of pure red cell aplasia by varicella zoster virus infection

Al-Anazi KA, Kanfar S, Aldayel A, Abduljalil O, Sayyed AH

Background: Pure red cell aplasia is characterized by anemia, reticulocytopenia and diminished bone marrow erythroid precursors. It has multifactorial etiology and consequently several therapeutic interventions.

04/26/2019
Review Article

Topical Management of chronic rhinosinusitis - A literature review

Aremu Shuaib Kayode* and Tesleem Olayinka Orewole

Chronic rhinosinusitis (CRS) is an inflammatory condition involving nasal passages and the paranasal sinuses for 12 weeks or longer [1]. It can be subdivided into three types: CRS with nasal polyposis (CRS with NP), CRS without nasal polyposis (CRS without NP), and Allergic fungal rhinosinusitis (AFRS).

04/15/2019
Research Article

Stability determination of candidate reference genes in cucumber plants subjected to stresses from Phytophthora melonis

Rui Wang, Hu Du, Qingmin Jin, Yu’e Lin, Yujuan Zhong, Chunpeng Yao, Xiaomei Xu and Tingquan Wu*

Stable reference genes are indispensable for ensuring the fidelity of determined gene expression levels. However, the expression levels of reference genes are unable to remain constant under all possible experimental conditions. Therefore, the stability determination of reference genes is necessary in an experimental system set.

04/19/2019
Letter to the Editor

Do you really want to improve the results of treatment for acute pneumonia?

Igor K

The question raised in the title of this letter is a natural consequence of the findings and conclusions that have been growing steadily in recent years regarding the results of treatment for acute pneumonia (АР). If you look at the publications of recent years in this field of medicine, it turns out that one of the main obstacles to progress in improving the results of treatment of this disease is the lack of appropriate methods for determining the pathogen.

04/16/2019
Research Article

The pattern of blood pressure and renal function among children with Sickle Cell Anaemia presenting in a tertiary health institution in Nigeria

Ajite A, Ogundare E, Oluwayemi O, Olatunya O, Oke O, et al.

Background: In sickle cell anemia (SCA), compromise of the renal vasculature due to sickled red cells has been recognized.
Objectives: To assess the renal function and blood pressure pattern in children with sickle cell anaemia (SCA) presenting in a tertiary institution.

04/15/2019
Research Article

Can bloodstream infection be predicted by nasal culture in hemodialysis patients?

Broumand B, Boroumandi S, Rahbar Z, Sheikhvatan M, Shahroukh M

The blood and drainage cultures are suggested for early diagnosis of bloodstream infection (BSI), which are time consuming and laborious. Nasal colonization of bacteria is one of the modalities, occasionally can predict BSI. We hypothesized that nasal culture, as an accessible fluid may be helpful to predict future BSI in hemodialysis patients.

03/28/2019
Opinion

Moving space-matter as the basis of the intelligence in the Physical World

Dizhechko BS

The concept of space-matter motion in the new Cartesian physics, based on the identity of space and matter, creates the basis for the study of consciousness as the action of the brain in space inside and outside itself and offers a way of materialistic explanation of life on Earth.

04/02/2019
Research Article

Knowledge, attitude, practice and associated factors towards nursing care documentation among nurses in West Gojjam Zone public hospitals, Amhara Ethiopia, 2018

Andualem A, Asmamaw T, Sintayehu M, Liknaw T, Edmealem A, et al.

Background: In health care systems nursing care documentation is a vital and powerful tool that ensures continuity of care and communication between health personnel for better patient outcomes. Knowledge, attitude and practice of nurses’ towards nursing care documentation affect the quality and coordination of patients’ care.

04/03/2019
Review Article

Hypertension as a persistent public health problem. A position paper from Alliance for a Healthy Heart, Mexico

Luis Alcocer, Humberto Álvarez-López, Gabriela Borrayo-Sánchez, Ernesto Germán Cardona-Muñoz, Adolfo Chávez-Mendozaa, Enrique Díaz y Díaz, José Manuel Enciso-Muñoz, Héctor Galván-Osegueraα, Enrique Gómez-Álvarez, Pedro Gutiérrez-Fajardo, Héctor Hernández y Hernández, Francisco Javier León-Hernández, José Antonio Magaña-Serrano, José Zacarías Parra-Carrillo and Martin Rosas-Peralta*

Today, Mexico has more than 130 million inhabitants; 85 millions of them are adults of 20 or more years old. The population pyramid is still one of base wider and this base corresponds to adults younger than 54 years old. Despite predictions made 20 years ago, about a transformation of the population pyramid shape to a mushroom shape as a consequence of more life expected and adult population growth; this change has not been occurred.

03/04/2019
Research Article

Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, Alzheimer Disease and other Neurodegenerative Diseases

Luisetto M, Almukhtar N, Rafa AY, Ahmadabadi BN, Mashori GR, et al.

Aim of this work is to verify the effect of some neurotoxins, physical factors and geography in presentation of some Relevant Neurological disorder like some form of ASL, PD, AD.

In
04/03/2019
Case Report

A serious pulmonary infection secondary to disseminated Strongyloidiasis in a patient with Nephrotic syndrome

Ma M, Cui S, Luo T, Chen Z, Yin L

We report a case involving infection with Strongyloides stercoralis found in the sputum of a 66-year-old male patient who had a medical history of nephrotic syndrome and was treated with methylprednisolone and monthly intravenous cyclophosphamide therapy 3 months previously. This patient presented with stubborn pulmonary symptoms and signs, which was the mechanical destruction caused by larval migration. We found strongyloides in his sputum that provided diagnostic proof.

04/03/2019
Research Article

Peritonitis: Culprit for peritoneal dialysis decline

Kumar K, Kumar J, Naureen C

Peritonitis is the main complication of peritoneal dialysis caused the withdrawal of treatment like peritoneal dialysis which was used as primary treatment modality few years back in Pakistan. With this motto to know the exact cause of peritonitis this retrospective study was done and 35 out
of 42 pervious peritoneal dialysis patients who had peritonitis were analyzed using old data.

04/03/2019
Case Report

Anti-glomerular basement membrane disease: A case report of an uncommon presentation

Silva N, Oliveira L, Frutuoso M, Morgado T

Anti-glomerular basement membrane (anti-GBM) disease is an uncommon autoimmune disease that classically presents as an aggressive necrotizing and crescentic glomerulonephritis (CG), with or without pulmonary hemorrhage, and typically does not relapse.

04/02/2019
Opinion

Managing epileptic women in pregnancy

Soomar SM, Rajpali S

Epilepsy is commonly seen in women of reproductive age and it is affecting their reproductive and pregnancy outcomes in an adverse manner [1]. It has seen that there are increased numbers of maternal deaths of pregnant women with epilepsy than those who have no any epilepsy symptoms or episodes.

04/05/2019
Case Report

Local recurrence after enlarged total nephrectomy

Graiouid M, Bai W, Gallouo M, Mohammed D, Debbagh A, et al.

Local isolated recurrence of kidney cancer in the renal lodge after radical nephrectomy is rare and has a poor prognosis. Surgical excision, sometimes even extended to neighboring organs, is currently the only effective treatment for local recurrence of kidney cancer. The interest of new medical therapies remains to be defined. We report a case of local recurrence in a patient with radical nephrectomy.

03/08/2019
Case Report

A Case of Acute Peripheral Vertigo: Using the HINTS Exam to guide diagnostic workup

Thong G, Casserly P

Acute dizziness/vertigo is among the most common causes for visiting the emergency department or primary care physician. Although the majority of these presentations represent an acute peripheral vestibulopathy (APV), lateral medullary, lateral pontine, and inferior cerebellar infarctions can mimic APV very closely.

04/28/2019
Research Article

Isolation and biochemical characterization of Plant Growth Promoting (PGP) bacteria colonizing the rhizosphere of Tef crop during the seedling stage

Zerihun Tsegaye*, Birhanu Gizaw, Genene Tefera, Adey Feleke, Solomon Chaniyalew, Tesfaye Alemu and Fasil Assefa

The use of novel PGPR as bio inoculant is an alternative sustainable agricultural practice to improve soil health, grain quality, increase crop productivity, and conserve biodiversity. The aim of this study is to isolate, and characterized PGP bacteria colonizing tef rhizosphere during the seedling stage.

03/12/2019
Research Article

Evaluation of cold response in Ilex paraguariensis

Sandonaid Andrei Geisler, Carina Francisca Argüelles and Cristian Antonio Rojas*

Ilex paraguariensis, also known as ‘Yerba mate’, occurs naturally in Argentina, Brazil and Paraguay and is also grown in these countries with different intensities. Leaves and branches of this plant are used in the preparation of a stimulant beverage that beside social importance
has notorious health impact.