Research Article

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and inflammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem a...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001023 Citation

Short Communication

Not-motorized Implantable Cardiac Assistance (NICA): Hemodynamic concepts and clinical perspectives

The considerable improvements in cardiac support systems technologies have not solved until now the problem of connecting the cardiac assistance devices (CAD) to external energy sources, which makes these Patients at risk of lethal infections and dependent on external batteries with few hours ...

Read Full Article HTML DOI: 10.29328/journal.jccm.1001038 Citation

Research Article

Postural and Kynematic effect of a new custom-made foot insole called “Prodynamic” in a cohort of patients affected by extrapiramidal disease

Background: The use of a custom-made orthotic plantar device is referenced as a true sensor-motor facilitation tool for the control of the postural orthostatic and orthodynamic position in patients with Parkinson’s

Read Full Article HTML DOI: 10.29328/journal.jnpr.1001027 Citation

Case Report

A successful case report in woman: A gender medicine?

Introduction: Abdominal hernia is a pathological condition resulting from abnormal protrusion of abdominal viscera. In particular, internal hernias (IH) represents about 0.2-0.9% of all cases with para- duodenal hernias while obturator hernias accounting for only 0.07% of all ...

Read Full Article HTML DOI: 10.29328/journal.ascr.1001029 Citation

Research Article

Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, Alzheimer Disease and other Neurodegenerative Diseases

Aim of this work is to verify the effect of some neurotoxins, physical factors and geography in presentation of some Relevant Neurological disorder like some form of ASL, PD, AD.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001019 Citation

Case Report

Squamous cell carcinoma developed on neglected, mistreated and delayed diagnosed chronic venous leg ulcer

Chronic venous leg ulcers (VLU), especially long-lasting non-healing ulcers, are among the risk factors for squamous cell carcinoma (SCC) with particularly aggressive behaviour. We present a case of a 71-year-old female patient with a relevant personal history of multiple SCC and basal cell ca...

Read Full Article HTML DOI: 10.29328/journal.ascr.1001026 Citation

Research Article

Endogenus toxicology: Modern physio-pathological aspects and relationship with new therapeutic strategies. An integrative discipline incorporating concepts from different research discipline like Biochemistry, Pharmacology and Toxicology

Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro- e...

Read Full Article HTML DOI: 10.29328/journal.acst.1001004 Citation

Research Article

TRIA-MF protocol as an innovative tool in the comprehensive treatment and outcome evaluation of lower limb amputees before and after prosthesis use

Background: A structured multidisciplinary team is very important during every phase of the amputation process and a good communicative team guarantees a greater tranquility for the patient, thanks to more homogenous information, that is already discussed between the clinician...

Read Full Article HTML DOI: 10.29328/journal.jnpr.1001024 Citation

Research Article

Endogenous archeological sciences: Physiology, Neuroscience, Biochemistry, Immunology, Pharmacology, Oncology and Genetics as instrument for a new field of investigation? Modern global aspects for a new discipline

In this work is analyzed scientific literature involved in human evolution to be used as an archeological Pathway to link different sciences in an overall new discipline.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001017 Citation

Research Article

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

In various patients conditions involved in lower urinary tract disease LUT (like overactive bladder, bladder neck sclerosis, dis –synergy (with our synenrgic contraction between bladder detrusor and bladder neck, BPH, recurrent cysytitis, interstitial cystitis, chronic prostatitis, uretr...

Read Full Article HTML DOI: 10.29328/journal.apcr.1001010 Citation

Research Article

Influence of an integrated rehabilitative treatment on the modification of body representation in patients affected by Unilateral Spatial Neglect

Background: In line with the so-called “embodiment concept”, human bodily experience is characterized by the immediate feeling that our body is localized in a certain position in space and that the self is localized within these body limits.

Read Full Article HTML DOI: 10.29328/journal.jnpr.1001023 Citation

Review Article

Neuroscience, Rehabilitation and New Technologies: Perspectives and critical points for a synergistic development

The growth of Rehabilitation, in all of its field and mainly in neuro-rehabilitation applications and settings, is showing increasingly strong interaction with the growth of technology and its innovative applications.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001015 Citation

Case Report

Hyperkalemia: An archenemy in emergency medicine. Description of two case reports

Potassium is an important ion capable to maintain intra-extracellular electric gradient. Variations in the intra-extracellular ionic flow may alter cells functions, skeletal and smooth muscle contractility and electric activity of myocardial cells.

Read Full Article HTML DOI: 10.29328/journal.jccm.1001029 Citation


COPD and low plasma vitamin D levels: Correlation or causality?

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death and its prevalence and incidence is also related to smoking behavior [1]. COPD is still a chronic inflammatory and progressive disease caused by multifactorial agents including environmental pollutants [2].

Read Full Article HTML DOI: 10.29328/journal.jprr.1001008 Citation

Research Article

Amyotropyc Lateral Sclerosis and Endogenous -Esogenous Toxicological Movens: New model to verify other Pharmacological Strategies

In 1874 J.M. Charcot was the first to describe ALS amyotrophic lateral sclerosis, a disease with an high non response therapy rate also to the actual therapy.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001009 Citation

Case Report

Herpes simplex virus (HSV)-1 encephalitis can induce chronic anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis

Herpes simplex virus (HSV)-1 encephalitis is the most common infectious cause of sporadic encephalitis. Despite treatment with acyclovir, HSV encephalitis is still associated with severe morbidity characterized by persistent neurological deficits.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001012 Citation

Case Report

Incidental findings in traditional nuclear medicine practice

The presence of an incidental finding, defined as an abnormality which is unrelated to the initial scanning indication, is widely increases due to the access to new devices and imaging modalities. This growing number of incidental findings can lead to additional medical care including unnecess...

Read Full Article HTML DOI: 10.29328/journal.jro.1001019 Citation

Research Article

Mindset kinetics and some depression status: A new quantitative model under biochemical - toxicology approach?

Depression: According Pubmed Health: Depression is a state of low mood and aversion to activity that can affect a person’s thoughts, behavior, feelings and sense of well-being (moderate or severe).

Can we consider some depression status due to high amount of s...

Read Full Article HTML DOI: 10.29328/journal.ida.1001008 Citation

Research Article

Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?

According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more ...

Read Full Article HTML DOI: 10.29328/ Citation Views: 810

Research Article

Perceptive and Rehabilitative Muscle Recruitment Facilitation Secondary to the use of a Dynamic and Asymmetric Spine Brace in the treatment of Adolescent Idiopathic Scoliosis (AIS)

Background: Supporting our adolescent people in realizing his/her self ability to reorganize and to establish a cross-linked paraspinal muscle control can be considered the most effective approach for muscle rehabilitation in adolescents affected by “AIS.

Read Full Article HTML DOI: 10.29328/journal.jnpr.1001021 Citation Views: 2128

Research Article

Brain and immune system: KURU disease a toxicological process?

Starting from observation of pathogenesis of KURU disease we try to investigate the immunologic role played by central nervous systems. A deeply knowledge in the transmission model of this pathology can be an imaging/diagnostic tool to Verify the progression of this prion molecule from gastro ...

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001010 Citation Views: 2354

Research Article

The Immunitary role in chronic prostatitis and growth factors as promoter of BPH

In the actual medical therapy of BPH, we can see: antibiotics, alpha blockers, 5-ARI, fitotherapeutics/natural products (Serenoa repens) with different which display clinical activities and other molecules such as FANS (local or systemic dosage forms) cortisones and others.

Read Full Article HTML DOI: 10.29328/journal.icci.1001003 Citation Views: 1216

Research Article

Bergamot Polyphenolic Fraction supplementation improves metabolic balance, endothelial function and maximal oxygen uptake in athletes

Background: The study aimed to evaluate the effects of a 4-week Bergamot Polyphenolic Fraction (BPF Gold; Bergamet Sport) supplementation on serum nitric oxide (NO), asymmetric
dimethyl-arginine (ADMA), Endopat indices of endothelial function and maximal oxygen uptake (V_ O2max) of ath...

Read Full Article HTML DOI: 10.29328/journal.jsmt.1001027 Citation Views: 4887

Research Article

Vestibular-limbic relationships Brain mapping

Vestibular disorders and anxiety are closely related, probably because they share some neuronal pathways. Ageing and patient comorbidities are important facilitating factors, and multiple vascular risk.
factors could contribute to the onset of a vestibular syndrome called vascular vert...

Read Full Article HTML DOI: 10.29328/journal.ida.1001006 Citation Views: 2803

Review Article

New pharmacological strategies in some metabolic endocrine disorder under a toxicological approach

In this review After Observing biomedical literature (starting from some heart disease) results that some pathological phenomena are deeply involved in some metabolic endocrine condition:

Read Full Article HTML DOI: 10.29328/journal.acem.1001006 Citation Views: 2503

Case Report

May we feed cancer?

The patient with an oncological disease presents a series of discomforts related to the psychological sphere such as depression, pain, sense of usefulness, anger, but also inconveniences related to food sphere. Neoplastic disease interferes with eating behaviour for several reasons.

Read Full Article HTML DOI: 10.29328/journal.ida.1001005 Citation Views: 3423

Research Article

Comorbidity of alcohol dependence with attention-defi cit/hyperactivity disorder and the role of executive dysfunctions

Background: This study aims to retrospectively investigate the comorbidity of ADHD multiple symptoms (behavioral) with alcohol addiction in a sample of adult alcohol-dependent patients and to test their current attentional skills (behavioral and cognitive).

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001008 Citation Views: 2713

Short Communication

Brain response in some systemic immune condition-Toxicological aspects

From biomedical literature “autism disorder are involved in young patient, that we have abnormalities (Imaging, histology) in some brain areas, and a comples symptomatology.

Read Full Article HTML DOI: 10.29328/journal.icci.1001002 Citation Views: 2429

Case Report

It is not invisible! A case report of 2 patients with scalp Lichen Planopilaris mimicking Androgenic Alopecia

Lichen Planopilaris is known as the form of Lichen Planus typical of the scalp. It is classified as a lymphatic disease and is characterized by chronic inflammation which leads to cicatricial alopecia.

Read Full Article HTML DOI: 10.29328/journal.adr.1001003 Citation Views: 3866

Research Article

Intraepidermal Injections of Autologous Epidermal Cell Suspension: A new promising approach to Dermatological Disorders. Preliminary Study

Regenerative medicine is a modern approach of dermatological treatment, using Epidermal Cells of the interfollicular epidermis (ESCs) for their effect in skin regeneration in chronic ulcers and burns, melanoma, vitiligo, junctional epidermolysis bullosa.

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001007 Citation Views: 4913

Review Article

Intensive Care Units (ICU): The clinical pharmacist role to improve clinical outcomes and reduce mortality rate- An undeniable function

Observing relevant biomedical literature we have see that clinical pharmacist play a crucial role in ICU settings with reducing in mortality rate and improving some clinical outcomes.

Read Full Article HTML DOI: 10.29328/journal.jcicm.1001010 Citation Views: 3138

Research Article

Thirty days post-operative complications after Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass/one Anastomosis Gastric Bypass. Analysis of the Italian Society for Bariatric Surgery and Metabolic Disorders (S.I.C.OB.) database of 7 years time frame

Background: To date, the scientific community has mainly focused on outcomes of obesity surgery such as weight loss and resolution of associated complications. Adverse post-operative events and reoperation rates have been poorly reported even if they are a marker of surgical s...

Read Full Article HTML DOI: 10.29328/journal.ascr.1001011 Citation Views: 4688

Research Article

Cumulative Effect Assessment: preliminary evaluation for Environmental Impact Assessment procedure and for environmental damage estimation

The paper presents and develops the issue of Cumulative Effect Assessment (CEA) in the Environmental Impact Assessment (EIA) screening procedure established by the State and Regional regulations In Italy.

Read Full Article HTML DOI: 10.29328/journal.acee.1001008 Citation Views: 3251

Research Article

Chlorophylls and xanthophylls of crop plants as dyes for Dye- Sensitized Solar Cells (DSSC)

Natural dyes have become a viable alternative to expensive and rare organic sensitizers because of their low cost, easy attainability, abundance of supply of raw materials and environmental friendliness.

Read Full Article HTML DOI: 10.29328/journal.jpsp.1001011 Citation Views: 4462

Research Article

Efficacies of 11% Lactoferricin and 0.05% Chlorhexidine Otological Solution compared, in the treatment of microbialotic overgrowth: A randomized single blinded study

Background: Topical therapy with antimicrobial agents is used in otitis treatment. Due to increase of antibiotic resistance, new strategies are needed. Antiseptics are used but they may induce contact dermatitis. Natural antimicrobial peptides may represent future effective dr...

Read Full Article HTML DOI: 10.29328/journal.ivs.1001004 Citation Views: 4051

Review Article

Ra-223 dichloride management in a Nuclear Medicine Unit: experience of a referral institution

Ra-223 dichloride is a first-in-class alpha-emitting radiopharmaceutical recently introduced into clinical practice for treatment of men with Castration-Resistant Prostate Cancer (CRPC) and symptomatic bone metastases.

Read Full Article HTML DOI: 10.29328/journal.jro.1001010 Citation Views: 4895

Research Article

Fluticasone furoate/Vilanterol 92/22 μg once-a-day vs Beclomethasone dipropionate/Formoterol 100/6 μg b.i.d. in asthma patients: a 12-week pilot study

Two of the most recent LABA/ICS combinations for treatment of persistent asthma are Fluticasone furoate/Vilanterol 92/22 μg (Ellipta) and Beclomethasone dipropionate/Formoterol 100/6 μg (Nexthaler).

Read Full Article HTML DOI: 10.29328/journal.jprr.1001004 Citation Views: 5254

Research Article

The master regulator gene PRDM2 controls C2C12 myoblasts proliferation and Differentiation switch and PRDM4 and PRDM10 expression

The Positive Regulatory Domain (PRDM) protein family gene is involved in a spectrum variety of biological processes, including proliferation, differentiation and apoptosis: its member seem to be transcriptional regulators highly cell type and tissue peculiar, towards histones modifications or ...

Read Full Article HTML DOI: 10.29328/journal.hjbm.1001007 Citation Views: 4406

Case Report

Evolution of anaesthesia in transapical aortic valve implantation Running head: Anaesthesia and transcatheter valve

The Transcatheter Aortic Valve Implantation (TAVI) had emerged more and more in the last twenty years. According to the scientific literature, this is an approved, suitable and alternative therapeutic choice to conventional surgery for aortic valve disease in high risk patients.

Read Full Article HTML DOI: 10.29328/journal.hacr.1001003 Citation Views: 4827

Case Report

A new heart: portraying the physiologic anatomo-functional reconstruction in ischemic cardiomyopathy

Fiber-based model of the left ventricle is known since 1628 but the complex 3D structure of myocardial fibers has not taken into account in normalcy or in disease until the last decade. We here present the case of a 60-year-old female patient affected by ischemic cardiomyopathy and severe left...

Read Full Article HTML DOI: 10.29328/journal.jccm.1001016 Citation Views: 3714

Letter to the Editor

The revolution of cardiac surgery evolution Running head: Cardiac surgery evolution

From the First case of primitive cardiac surgery (CS), treatment of stab wound of the heart (Dr. Daniel Hale Williams, 1893), to recent surgical procedures and device implantations for end-stage heart failure (HF), the CS has grown and emerged in the public health more and more [1].

Read Full Article HTML DOI: 10.29328/journal.ascr.1001007 Citation Views: 1680

Review Article

Surface Plasmon Resonance technology to assess biological interactions

Molecular interactions between proteins or between proteins and small molecules are pivotal events for selective binding of biological structures and, consequentially, for their correct function. In this scenario, the evaluation of kinetic parameters, characterizing a molecular interactions, i...

Read Full Article HTML DOI: 10.29328/journal.hjbm.1001005 Citation Views: 5425

Research Article

How does a Personalized Rehabilitative Model infl uence the Functional Response of Different Ankle Foot Orthoses in a Cohort of Patients Affected by Neurological Gait Pattern?

Background: Orthoses need to support physiotherapy as well as surgical treatment. Related to patient’s rehabilitative goals and pathological gait pattern, orthotists have to produce an orthoses that using an adjustable ankle joint system with preloaded disc springs can s...

Read Full Article HTML DOI: 10.29328/journal.jnpr.1001010 Citation Views: 4525

Review Article

Surgery and new Pharmacological strategy in some atherosclerotic chronic and acute conditions

In actual pharmacological therapy we can see that some drugs can be added to other medical instruments to improve their activity: in example we can see medicated stent for some coronary disease, or hormonal medical devices used in pregnancy prevention, but other example are known today.

Read Full Article HTML DOI: 10.29328/journal.ascr.1001006 Citation Views: 4892

Review Article

Transglutaminase inhibition: possible therapeutic mechanisms to protect cells from death in neurological disorders

Transglutaminases are a family of Ca2+-dependent enzymes which catalyze post-translational modifi cations of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition ...

Read Full Article HTML DOI: 10.29328/journal.hjbm.1001004 Citation Views: 4931

Short Communication

Function Prediction of Proteins from their Sequences with BAR 3.0

Protein functional annotation requires time and effort, while sequencing technologies are fast and cheap. For this reason, the development of software tools aimed at predicting protein function from sequences can help in protein annotation.

Read Full Article HTML DOI: 10.29328/journal.hpbr.1001001 Citation Views: 1779

Research Article

Wave Forces on Vertical Structures in Shallow Water: Numerical Evaluation

The actions exerted by waves on a coastal structure very much depend upon hydrodynamic processes that originate on shallow waters; even though significant progresses have been made in the last few years towards a full understanding of wave breaking, design work is still largely based on classi...

Read Full Article HTML DOI: 10.29328/journal.acee.1001003 Citation Views: 3901

Case Report

Recurrent Cardiac Events Driven by Prothrombotic Burden in a Patient Undergoing Lipoprotein Apheresis for High Lp(a) Levels

Introduction: Lipoprotein (a) [Lp(a)] is a marker for cardiovascular disease, involved in pathogenesis and progression of atherosclerosis. In selected high-risk patients, lipoprotein-apheresis could optimize secondary prevention and improve prognosis.

Read Full Article HTML DOI: 10.29328/journal.hcem.1001001 Citation Views: 3929

Review Article

Rhabdomyoblasts in Pediatric Tumors: A Review with Emphasis on their Diagnostic Utility

Rhabdomyosarcoma is a soft tissue pediatric sarcoma composed of cells which show morphological, immunohistochemical and ultrastructural evidence of skeletal muscle differentiation. To date four major subtypes have been recognized: embryonal, alveolar, spindle cell/sclerosing and pleomorphic.

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001002 Citation Views: 4897

Case Report

Hypoglycemia by Ginseng in type 2 Diabetic Patient: Case Report

Ginseng extracts are often used as adaptogen to improve mental performances and well being, helping to overcome stress. Thus, in our times a lot of ginseng extracts are continuously produced and sold into commercial channels. Both Asian and Korean red ginseng (Panax ginseng) and American ginse...

Read Full Article HTML DOI: 10.29328/journal.hodms.1001001 Citation Views: 3861