August 2021

Flow cytometry potential applications in characterizing solid tumors main phenotype, heterogeneity and circulating cells

Louis WAECKEL, Guorong LI, Anne-Emmanuelle BERGER and Claude LAMBERT*

Abstract

Flow cytometry (FCM) is a unique technique that allows rapid quantitative measurement of multiple parameters on a large number of cells at the individual level. FCM is based on immunolabelling with fluorochrome-conjugated antibodies, leading to high sensitivity and precision ...

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Non-alcoholic fatty liver disease: Update on treatment options and translational implications of sleep disruption

Steve M D’Souza, Byung S Yoo, Kevin V Houston, Ankit J Patel, Parth J Parekh and David A Johnson*

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a condition that is associated with cirrhosis and hepatocellular carcinoma, and is increasing in prevalence worldwide. Sleep disruptions are commonly seen in NAFLD, and the disease process is associated with sleep disorders, includ...

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Victim of violent death: what is the role of alcoholemia?

Ivan Dieb Miziara* and Carmen Silvia Molleis Galego Miziara

Abstract

Introduction: The tendency to impulsive behaviors and/or violence is exacerbated after alcohol consumption. Still, the relation between alcohol/violent deaths reported in the literature is not accurate, and in general, alcohol is only seen as a trigger to aggressive actions. ...

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Evaluation of the effectiveness of transcranial electrostimulation in treatment of neuropsychiatric disorders

Gagik Hakobyan*, Eduard Sekoyan, Karyna Shoman and Krasnopeeva Ekaterina

Abstract

Objectives: Evaluation of the effectiveness the method of transcranial electrostimulation in treatment of neuropsychiatric disorders with the use of a patches by the company “Aganyan”.

Materials and methods: The study was a double-blind, randomized, plac...

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An incidental case report of Disc Battery Ingestion in a child with congenital hearing loss

Betsy Mathew* and Ananta Jois

Foreign body ingestion in children is a serious problem encountered among children. Approximately 80% of cases of foreign body ingestions occur in children between the ages of six months and three years [1]. Button battery ingestion occurs at an estimate rate of ten in one million people per year...

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Immunocompromised patients with SARS-CoV-2 infection in intensive care units, outcome and mortality

Cynthia DENIS*, Hamid MERDJI, Mathieu BALDACINI, Maleka SCHENCK, Thierry ARTZNER, Yoann GRIMAUD, Thierry LAVIGNE, Ferhat MEZIANI, Vincent CASTELAIN, Raphaël CLERE-JEHL, Francis SCHNEIDER and Guillaume MOREL

Abstract

Background: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak severely hit Northeastern France from March to May 2020. The massive arrival of SARS-CoV-2 positive patients in the intensive care units (ICU) raised the question of how immunocompromise...

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Evaluation of microbial contamination in a surgical department of a Romanian military emergency hospital - A case study

Bogdan-Ioan Coculescu* and Elena Claudia Coculescu

Abstract

Assessment of the microbial load of the operating environment during daily pre-, intra-, and post-operative procedures in a surgical department of a military emergency hospital in Bucharest showed the bacterial contamination of intra-operative air by increasing the number of ...

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An algorithm to safely manage oral food challenge in an office-based setting for children with multiple food allergies

Nathalie Cottel, Aïcha Dieme, Véronique Orcel, Yannick Chantran, Mélisande Bourgoin-Heck and Jocelyne Just*

Abstract

Background: In France, from 30% to 35% of children suffer from multiple food allergies (MFA). The gold standard to diagnosis a food allergy is the oral food challenge (OFC) which is conducted in a hospital setting due to risk of anaphylaxis.

The aim of this study wa...

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Application and utility of alternative methods in isolation of pure cells from forensic biological mixtures in modern-day: a review

Suneel Prajapati*, Poonam Rajmane, P Jayakrishna, Maya S Nair, Priyanka Kshirsagar and Mukul Meshram

Summary

Development of genetic profiles from the biological mixtures has remained challenging, although modern-day technologies may help forensic scientists to attain a reliable genetic profile in the identification of the accused.

In the case of rape, vaginal swab exhibits ...

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Difference between conventional and modern methods for examination of fingerprints

Ambati Ramesh Babu*

Abstract

The impression of frictional ridges of the finger is known as fingerprints. Owing to this uniqueness, the fingerprints have long been used to identify a person since Ancient times. In any crime scene the presence of fingerprint makes the identification of the Culprit very easy....

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Strobilurins: New group of fungicides

Rasha E Selim* and Mohamed S Khalil

Abstract

Strobilurin is a group of natural products and their synthetic analogs have been widely used to control and prevent fungal diseases. Strobilurins were firstly isolated in 1977 from the mycelium of Strobilurus tenacellus, a saprobic Basidiomycete fungus causing wood-rotting on...

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MALDI-MSI method for the detection of large biomolecules in plant leaf tissue

Lilian ST Carmo, Daiane G Ribeiro, Eder A Barbosa, Luciano P Silva and Angela Mehta*

Abstract

In this study we describe a method for the detection of biomolecules (in the polypeptide m/z range) directly from the surface of plant leaves by using Mass Spectrometry Imaging. The plant-pathogen interaction between Arabidopsis thaliana and the bacterium Xanthomonas campestr...

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An educational strategy for the implementation of a delirium assessment tool

Beatriz Bonaga*, Elena Ruiz-Escribano Taravilla, Carmen Carrilero-López, María Dolores Castillo-Lag, Leanne M Boehm, Ángela Prado Mira, María Joaquina Piqueras Diaz and E Wesley Ely

Abstract

Background: Delirium is an acute syndrome of organ dysfunction with long-term consequences which commonly occurs in the Intensive Care Unit (ICU). The incidence of delirium ranges from 30% - 50% in low severity ICU patients and up to 80% in mechanically ventilated patients. T...

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Factors influencing referral delay of cancer patients to an oncology unit in the Southern Region of Saudi Arabia

Ali M Al Zahrani*, Hatim M Ali, Shaza A Ahmed, Ahmed M Abdelakher, Asma A Al Zahrani and Hatoon Bakhribah

Abstract

Introduction: Cancer treatment and prognosis depend heavily on early detection. Survival in the early stages is excellent for almost all types of cancer. Unfortunately, in Saudi Arabia, a large number of cancer patients present with advanced disease, resulting in a poor progn...

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Leiomyosarcoma in pregnancy: Incidental fi nding during routine caesarean section

Toon Wen Tang* and Phoon Wai Leng Jessie

Abstract

Uterine leiomyosarcoma (LMS) is uncommon tumour arising from the female reproductive tract. Incidence of LMS in pregnancy is extremely rare, with only 10 cases reported thus far in medical literature.

We present a case of myomectomy performed during elective caesare...

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A rare presentation of orbital dermoid: A case study

Sheetal V Girimallanavar*, Seema Channabasappa, Balasubrahmanyam Aluri, Divya Rose Cyriac and Aiswarya Ann Jose

Summary

Introduction: A dermoid cyst is a developmental choristoma lined with epithelium and filled with keratinized material arising from ectodermal rests pinched off at suture lines. These are the most common orbital tumors in childhood. They are categorized into superficial and dee...

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A comparative study of post-operative astigmatism in superior versus superotemporal scleral incisions in manual small incision cataract surgery in a tertiary care hospital

Soumyadeep Hazra* and Tapes Kanti Saha

Abstract

Background: In developing countries, manual small incision cataract surgery is a better alternative and less expensive in comparison to phacoemulsification and thus the incision is an important factor causing high rates of postoperative astigmatism resulting into poor visual ou...

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SARS-CoV-2 Infection, COVID-19, and long covid: Saga of erratic immune response, waning immunity, and immune system failure

Vinod Nikhra*

Abstract

Introduction - evolution of SARS-CoV-2 variants: With the unrestrained pandemic for over last one-and-half year, SARS-CoV-2 seems to have adapted to its habitat, the human host, through mutations that facilitate its replication and transmission. The G variant incorporating D6...

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“Fatty Lungs”: An uncommon case of Autoimmune Pulmonary Alveolar Proteinosis

Arnaldo A Nieves-Ortiz*, Kyomara Hernandez-Moya, Juan Garcia-Puebla, Kimberly Padilla-Rodriguez, Neshma Roman-Velez, Giovanni Veloz-Irizarry, Keren Mendez-Ramirez, Hector Collazo-Santiago, Jose Adorno-Fontanez and Ricardo Fernandez-Gonzalez

Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease characterized by excessive accumulation of surfactant lipids and proteins in alveoli and terminal airways. It is caused by impaired GM-CSF signaling [1]

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“Vanishing” breast implant – when a breast prosthesis is moving into the pleural cavity

Thomas Grieser*, Daniel Popp, Stephan Raab and Thomas Berghaus

A 57-year-old woman has been referred to our hospital in April 2020 because of suffering necrotizing pneumonia in the right upper lung lobe secondary to preceding pulmonary embolism half a year ago (Figure 1A,B).

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Non-smoking woman with adenocarcinoma of the lung, IV stage with ROS1 mutation and acquired thrombophilia

Immanuels Taivans*, Natalja Senterjakova, Viktors Kozirovskis, Gunta Strazda, Jurijs Nazarovs and Valentina Gordjusina

Abstract

Despite the fact, that lung cancer is more common among older smoking men, however it may also develop among young women without a smoking anamnesis. We report here a history of a non-smoking woman, 40 years old, with a diagnosis of lung adenocarcinoma at IV stage. Despite th...

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Associations of adverse social determinants of health with missed well-child visits and the role of caregiver social support

William Roberts, Eun Ji Kim*, Johanna Martinez and Omolara Thomas Uwemedimo

Abstract

Objective: To examine the association between adverse social determinants of health (SDH) and missed well-child visits and the interaction with the level of caregiver social support.

Methods: This is a secondary data analysis of data collected from a SDH screening p...

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