02/22/2019
Review Article

The role of genetic mutations in genes LMNA, PPARG, PLIN1, AKT2, CIDEC in Kobberling–Dunnigan Syndrome

Shahin Asadi* and Mahsa Jamali

Abstract

Köbberling-Dunnigan syndrome, also known as partial familial lipodystrophy, is a rare genetic disorder characterized by abnormal distribution of adipose tissues. Many people with Köbberling-Dunnigan syndrome develop insulin resistance, a condition in which body tiss...

02/22/2019
Case Report

Hypocomplementemic interstitial nephritis with long-term follow-up

Alyssa Penning, M.D, Claire Kassakian, M.D, Donald C Houghton, M.D and Nicole K Andeen, M.D*

Abstract

Prednisone-sensitive hypocomplementemia, renal insufficiency, and kidney biopsy demonstrating severe tubulointerstitial nephritis (TIN), storiform fibrosis, and tubulointerstitial immune deposits are typical of IgG4-related tubulointerstitial nephritis and hypocomplementemic ...

02/22/2019
Research Article

Diagnostic accuracy of TIMI versus GRACE score for prediction of death in patients presenting with Acute Non-ST Elevation Myocardial Infarction (NSTEMI)

Syed Haseeb Raza Naqvi, Tariq Abbas, Han Naung Tun*, Ali Ahmad Naqvi, Zubair Zaffar, Badar ul Ahad Gill and Nisar Ahmad

Abstract

Background: Acute Coronary Syndrome describes a spectrum of disease ranging from unstable angina through non-ST-Elevation Myocardial Infarction (NSTEMI) to ST-Elevation Myocardial Infarction (STEMI). Early death in NSTEMI is usually due to an arrhythmia. Pati...

02/14/2019
Research Article

Biological dose calculation using variable RBE in Single- and Multi-field Optimization IMPT plans for 3 Brain Tumor patients

Ryosuke Kohno*, Wenhua Cao, Pablo Yepes, Xuemin Bai, Falk Poenisch, David R Grosshans, Tetsuo Akimoto and Radhe Mohan

Abstract

Purpose: The purpose of this study was to evaluate biological dose in single-field optimization (SFO) and multi-field optimization (MFO) intensity-modulated proton therapy (IMPT) plans for brain tumor patients that used a fixed relative biological effectivene...

02/19/2019
Research Article

Biliary reflux gastritis after Mini Gastric Bypass: The effect of Bilirubin level

Mohamed Lasheen, Mohamed Mahfouz, Tamer Salama* and Hossam El-Deen M Salem

Abstract

Background: Minigastric bypass is gaining popularity worldwide as an effective bariatric surgery which has fewer complications than RYGB. There is raising concerns about biliary reflux and its effect on gastric mucosa. In this study we tried to find the link ...

02/12/2019
Research Article

Application of autologous adipose-derived stem cells for thin endometrium treatment in patients with failed ART programs

I Sudoma, L Pylyp, Y Kremenska and Y Goncharova*

Introduction

One of the factors of assisted reproduction technology (ART) success is an adequate growth and development of endometrium. At the end of follicular phase of menstrual cycle endometrium reaches its greatest thickness. It is believed that there is a critical limit of endome...

02/08/2019
Research Article

Association of Toll-like receptor 2, 4, and 9 gene polymorphism with high altitude induced thrombosis patients in Indian population

Swati Sharma#, Iti Garg*#, Gauri Mishra, Babita Kumari, Lilly Ganju and Bhuvnesh Kumar

Abstract

Venous Thromboembolism (VTE) is a multifactorial disease that is influenced by individual genetic background and various environmental factors, high altitude (HA) being the one. HA exposure may cause release of several damage associated molecular patterns (DAMPs), which act a...

02/07/2019
Clinical Image

New technique of imaging cellular change to squmous cells metaplsia of cervix

Salwa Samir Anter*

Clinical Image

Flexible magnifying endoscopy with narrow band imaging (ME-NBI) has outstanding diagnostic correctness for gastrointestinal metaplsia and is hope for to be highly useful for imaging stage cervixcal metaplsia beginning by imaging the first stage of metaplasia by imaging ...

02/07/2019
Research Article

Risk definition in Laparoscopic versus Open Cholecystectomy

Abdelhamid MS, Nabil TM, Nafady HA, Garib AZ, Soliman SS

Abstract

Nothing without risk. As cholecystectomy is one of the most common procedures, any minor risk will be a mass volume. This study was to define the magnitude of that risk. In the study were 1486 patients between Feb. 2009 and April. 2018. Open in 292 (19.6%), 1194 (80.4%) lapar...

02/04/2019
Case Report

Squamous cell carcinoma developed on neglected, mistreated and delayed diagnosed chronic venous leg ulcer

Laura Maria Curic* and Marino Cordellini

Abstract

Chronic venous leg ulcers (VLU), especially long-lasting non-healing ulcers, are among the risk factors for squamous cell carcinoma (SCC) with particularly aggressive behaviour. We present a case of a 71-year-old female patient with a relevant personal history of multiple SCC...

02/01/2019
Research Article

Naphazoline nitrate treat the Frey effect of microwave and other sonic weapon’s damages in Human’s Internal, Endogenous Organs

Robert Skopec*

Abstract

State Department had evacuated a number of Americans from the U.S. consulate in Guangzhou, China after they experienced unexplained health issues. A group of U.S. diplomats stationed in China have been brought back to the states after being inflicted by a mystery illness that...

02/01/2019
Review Article

Renal function during exercise and recovery

Javier Calderón Montero*

Abstract

This review paper analyzes the response of renal function during two types of exercise: 1) exercise of increasing intensity and 2) exercise of submaximal intensity and prolonged duration. During an effort of increasing intensity there is a decrease in renal blood flow that, t...

02/07/2019
Opinion

Zoonotic potential of Giardia lamblia and control of giardiasis

Maria Fantinatti*

Opinion

Giardia is the most common pathogenic intestinal flagellate protozoan in the world. The most studied species is Giardia lamblia (syn. Giardia intestinalis, Giardia duodenalis) that infects mammals, including humans.About the other seven species the scientific literature is ver...

02/05/2019
Research Article

Phylogenetic analysis of metalloprotease from transcriptome of venom gland of Hemiscorpius lepturus

Fatemeh Kazemi-Lomedasht*, Delavar Shahbazzadeh and Mahdi Behdani

Abstract

Hemiscorpius lepturusis a dangerous scorpion and referred to health concern issue in Khuzestan, Iran. The venom of H.lepturus is cytotoxic and its effect is similar to spider Loxosceles reclusa. Metalloproteinases are the important class of enzymes in the venom that has hemor...

02/07/2019
Research Article

Angioarchitectonics of acute pneumonia

Klepikov Igor*

Abstract

The article presents the results of x-ray anatomical studies of 56 whole lung preparations, which were carried out immediately after the autopsy of children who died from АP. In 47 cases it was carried out the contrast of the vessels and in 9 cases the bronchial tree. The re...

02/04/2019
Research Article

Acute pneumonia: Facts and realities against etiological hypotheses and beliefs

Klepikov Igor

Abstract

Modern AP concepts are focused exclusively on the infectious nature of the disease and the presence of certain pathogens. This belief determines the principles of treatment, the lack of effectiveness of which remains a concern of health professionals. The article presents a f...