Review Article

Fibrinolytic therapy with tPA failed because it was based on a flawed concept

<h2>Abstract</h2> <p>Fibrinolytic therapy has become synonymous with tissue plasminogen activator (tPA) based on the belief that tPA alone was responsible for natural fibrinolysis. Although this assumption was belied from the outset by disappointing clinical results, it persiste...

Mini Review

Patients suffer when healthcare stocks rise

<p>When a stock price rises or has a better P/E ratio, this is generally considered a measure of success. Is this true for health insurance stocks? Stock holders certainly are happy, but what about the purchasers of the carriers&rsquo; policies? Are patients smiling when the stock price go...

Review Article

Microbiome and Gastroesophageal Disease: Pathogenesis and Implications for Therapy

<h2>Abstract</h2> <p>There is growing evidence that gastroesophageal disease is influenced by the esophageal microbiome, and that commensal bacteria of the oropharynx, stomach, and colon are thought to have a role in modulatiing pathogenesis. These emerging hypotheses are based ...

Research Article

Trial of labor after cesarean outcomes with excessive gestational weight gain

<h2>Summary</h2> <p>The success of vaginal birth after cesarean section (VBAC) has been correlated with a variety of maternal characteristics such as age, ethnicity, and body mass index (BMI, calculated as weight in kilograms divided by height in meters squared). The patient&...

Research Article

Role of community health fairs in providing health services, improving health of rural residents

<h2>Abstract</h2> <p><strong>Introduction:</strong> Obesity (BMI &ge; 30 kg m-2) is epidemic globally and is associated with increased risk for a wide range of physical and mental health comorbidities. This is a particular concern for rural residents who have a g...

Case Report

Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate

<p>The emergence of COVID-19 worldwide in an unprecedented pandemic. COVID-19 has a significant mortality, mostly from acute lung injury. We reviewed the available literature from China and Europe in regard to the behavior of SARS-Cov2 and ability to adhere to the cell wall [1,2]. The evidence...

Review Article

Contemporary American stupidity

<p>The American character is filled with contradictions and paradoxes [1], so it is understandable that, being susceptible to the imperfections, weakness and evils afflicting all peoples [2], it features its share and many types of injustices and stupidity.</p>

Research Article

Neuroticism and BMI: The role of genetic tendency, behavior and environment on body weight

<h2>Abstract</h2> <p><strong>Introduction:</strong> Recent research has explored the role that personality traits play in health and weight determination. This study extends current research by evaluating the extent to which behavior mediates the impact of neuroticis...

Research Article

A comparative study of solid waste management in the United States, Europe and Asia

<h2>Abstract</h2> <p>Managing municipal solid waste correctly is critical to the success of a society. Many regions and countries in the world are behind others in the context of solid waste management. In order to compare three such regions within this context, a meta-analysis ...

Research Article

Rural adolescent health: Issues, behaviors and self-reported awareness

<h2>Abstract</h2> <p><strong>Purpose:</strong> The purpose of the study was to examine the health status of rural adolescents and young adults in the United States through a comprehensive review of detailed health information, behavior and health awareness. The dispa...

Opinion

PR and QT intervals short on the same electrocardiogram

<p>In 2007, Professor Breijo-M&aacute;rquez described an electrocardiographic pattern, consisting of the presence of a short PR interval (or PQ) together with a short QT interval in the same individual. It was published with the headline &ldquo;Decrease in cardiac electrical systole&am...

Review Article

His bundle pacing in heart failure: A review of current literature

<h2>Abstract</h2> <p>Biventricular (BiV) pacing revolutionized the heart failure management in patients with sinus rhythm and left bundle branch block; however, left ventricular-lead placement is not always technically possible. Also, BiV pacing does not fully normalize ventricu...

Research Article

A quantum mechanical model for hole transport through DNA: predicting conditions for oscillatory/non-oscillatory behavior

<h2>Abstract</h2> <p>A quantum mechanical model that considers tunneling and inelastic scattering has been applied to explain the hole transfer reaction from a G (Guanine) base to a GGG base cluster through a barrier of Adenine bases, (A)n (<em>n</em> = 1-16). For &l...

Research Article

Sensitivity and Intertextile variance of amylase paper for saliva detection

<h2>Summary</h2> <p>Contemporary forensic science hinges on DNA analysis to link an individual to a crime scene. Sources of DNA include bodily fluids, including saliva. Amylase is a primary enzyme in human saliva and thus, if detected, indicates possible presence of human saliva...

Research Article

In vitro and preventative field evaluations of potential biological control agents and synthetic fungicides for control of Clarireedia jacksonii sp. nov.

<h2>Abstract</h2> <p>Clarireedia jacksonii sp. nov. Formerly Sclerotinia homoeocarpa F.T. Bennett, the causal agent of dollar spot (DS), is the most destructive pathogen in turfgrass. Symptoms appear as circular patches 10-40 mm in diameter with small tan lesions surrounded by a...

Research Article

Low sensitivity of the careHPV™ Assay for detection of Oncogenic Human Papillomavirus in cervical samples from HIV-infected and HIV-uninfected Kenyan women

<h2>Abstract</h2> <p><strong>Background:</strong> Human papillomavirus (HPV) infection causes cervical cancer (CC), a common malignancy among Kenyan women. New CC screening methods rely on oncogenic HPV (&ldquo;high-risk&rdquo;, or HR-HPV) detection, but most...

Case Report

Granulomatosis with polyangiitis (GPA) in a 76-year old woman presenting with pulmonary nodule and accelerating acute kidney injury

<h2>Abstract</h2> <p>Granulomatosis with polyangiitis (GPA), a form of ANCA-associated vasculitis (AAV), is a rare disease with an often-occult presentation. It is more common in 4th and 5th decades of life but can be seen in all ages.</p> <p>This case report deta...

Research Article

Uterine precursor lesions in patients with incidental nodal lymphangioleiomyomatosis: A report of 4 cases

<h2>Abstract</h2> <p>Uterine sections from 6 patients with incidental nodal lymphangioleiomyomatosis (LAM) were examined for LAM lesions by screening these sections with cathepsin K immunohistochemistry (IHC) stains. The hysterectomy specimens were all concurrent with the lymph ...

Review Article

The Neppe-Close triadic dimensional vortical paradigm: An invited summary

<h2>Abstract</h2> <p>Physicists are generally trained in the Standard Model of Physics (SMP). This implies that they perceive and account for only 3 dimensions of space in a moment in time (3S-1t) (a 4-dimensional [4D] model). However, applying the SMP, more than fifty significa...

Research Article

Aggressive hydration in early resuscitation phase does not provide mortality benefit in acute pancreatitis

<h2>Abstract</h2> <p><strong>Introduction:</strong> Fluid management is the cornerstone of treatment for acute pancreatitis (AP), but the proper rate and volume is still controversial. We aim to evaluate the role of aggressive hydration in AP patients.</p> &...

Case Report

Embolic Septic Emboli with MRSA: A different source

<h2>Abstract</h2> <p>Septic Iliac vein thrombophlebitis with associated psoas abscess is a rare and severe entity, which diagnosis is challenging when no risk factor is clearly present. We are presenting a case of severe septic cavitary pulmonary emboli complicated with Acute Re...

Case Report

Brainstem Death due to hypertension induced brain hemorrhage

<h2>Introduction</h2> <p>Brain stem death is when a person has permanently lost the potential for consciousness and the capacity to breathe. When this happens, a machine called a ventilator keeps oxygen circulating through the person&rsquo;s bloodstream - a person confirmed ...

Research Article

Long-Term Impact of Coronary Artery Disease in Lung Transplantation

<p><strong>Background:</strong> Adoption of the Lung Allocation Score (LAS) has led to increased listing of older patients and those with idiopathic pulmonary fibrosis (IPF) for lung transplantation (LTX). Older patients and those with IPF have higher prevalence of coronary artery ...

Case Report

First trimester growth delay: An early marker of triploidy

<h2>Introduction</h2> <p>Triploidy is one the most common chromosomal abnormality in humans, complicating about 1% of all human pregnancies. Most affected conceptions undergo spontaneous abortion in the first trimester, making the prevalence of second trimester triploidy low. Vi...

Research Article

Evaluation of outcomes of 8-week therapy with ledipasvir/sofosbuvir or glecaprevir/pibrentasvir in veterans with hepatitis C infection

<h2>Summary</h2> <p>Hepatitis C Virus (HCV) infection is usually treated with direct acting antivirals (DAAs) for 12 weeks. In treatment naive patients with genotype (GT) 1 infection without cirrhosis and baseline viral load &lt;6 million, 8 weeks of Ledipasvir/Sofosbuvir (L...

Research Article

Left ventricular ejection fraction and contrast induced acute kidney injury in patients undergoing cardiac catheterization: Results of retrospective chart review

<h2>Abstract</h2> <p><strong>Background:</strong> Contrast-induced acute kidney injury (CI-AKI) is an important cause of increasing the hospital stay and in-hospital mortality. By increasing intra-renal vasoconstriction, left ventricular ejection fraction (LVEF) can ...

Opinion

States Care - The Cure for Patient Healthcare

<h2>Opinion</h2> <p>Clinical physicians believe they are drowning . . . because they are! Between complying with an ever-changing landscape of time-wasting federal regulations, avoiding Health Insurance Portability and Accountability Act violations, plus the entire billing proce...

Editorial

Pulse Synchronized Contractions (PSCs)

<h2>Editorial</h2> <p>A key platform underpinning the traditional understanding of the cardiovascular system, with respect to the behavior of large arterial vessels, is Otto Frank&rsquo;s Windkessel Hypothesis [1]. This hypothesis posits simply that the smooth muscle walls o...

Research Article

A Systematic review for sudden cardiac death in hypertrophic cardiomyopathy patients with Myocardial Fibrosis: A CMR LGE Study

<h2>Abstract</h2> <p><strong>Background:</strong> Hypertrophic cardiomyopathy (HCM) patients have a predisposition for malignant VT/VF and consequently, sudden cardiac death (SCD). In single center studies, late gadolinium enhancement (LGE) defined fibrosis has been ...

Review Article

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

<h2>Abstract</h2> <p>The biological changes caused by oxidative stress (OS) are known to be involved in the etiology of neurodegenerative disorders, including Alzheimer&rsquo;s disease, amyotrophic lateral sclerosis, Huntington&rsquo;s disease, and Parkinson&rsquo;s ...

Commentary

We may need to reconsider when to apply sunscreen in our daily life

<h2>Abstract</h2> <p>Broad-spectrum sunscreens are now widely used worldwide as an adjunct to help prevent sunburn, skin cancers and premature skin aging. In the United States, all persons older than 6 months are recommended to apply sunscreen to all sun-exposed skin from toes t...

Research Article

Comprehensive phenotypic characterization and genetic distinction of distinct goosegrass (Eleusine indica L. Gaertn.) ecotypes

<h2>Abstract</h2> <p>Goosegrass (Eleusine indica L. Gaertn.) is a troublesome weed in turfgrass systems throughout the world. The development of herbicide resistant ecotypes has occurred to multiple modes of action. Goosegrass is a prolific seed producer (~50,000 per plant), fas...

Review Article

A mouse model of coronary microvacsular disease using a photochemical approach

<h2>Abstract</h2> <p>The development of reproducible rodent models of coronary microvascular disease (MVD) is essential for the early detection, treatment, and mechanism study of the pathophysiology. We hypothesized that endothelial dysfunction and subsequent microthrombi in the...

Case Report

Unilateral retinitis pigmentosa: Case report and review of the literature

<h2>Abstract</h2> <p><strong>Significance:</strong> Due to the limited number of reported cases little is known about the characteristics of unilateral retinitis pigmentosa. Information from additional case reports can aid in learning more about the condition. We rep...

Case Report

Weight loss counseling for dialysis patients to prepare for transplant

<h2>Case Report</h2> <p>Obesity has become a worldwide Epidemic affecting more than 300 million people. Overweight is defined as BMI (Body Mass Index) of 25-29.9 kg/m2. Obesity is defined as BMI greater than 30 kg/m2, and Morbid Obesity is a BMI of &gt; than 35 kg/m2 [1].<...

Research Article

Gender and left ventricular structural and functional differences in pulmonary hypertension among end stage renal disease patients on maintenance hemodialysis

<h2>Abstract</h2> <p><strong>Introduction</strong>: Pulmonary hypertension (PH) is prevalent in hemodialysis (HD). In the general population, more women than men have PH due to left ventricular (LV) disease with preserved ejection fraction (EF). Little is known about...

Research Article

Role of novel cardiac biomarkers for the diagnosis, risk stratifi cation, and prognostication among patients with heart failure

<h2>Abstract</h2> <p><strong>Background:</strong> Current guidelines for diagnosis and management of heart failure (HF) rely on clinical findings and natriuretic peptide values, but evidence suggests that recently identified cardiac biomarkers may aid in early detect...

Letter to the Editor

Serum MicroRNA-155 in Acute Graft-Versus-Host-Disease (aGVHD)

<h2>Letter to Editor</h2> <p>Allogeneic hematopoietic stem cell transplant (alloHSCT) is a curative treatment for many hematologic malignancies. Unfortunately, about&nbsp; 30-50% of all recipients undergoing alloHSCT develop acute graft-versus-host-disease (aGVHD), which is ...

Research Article

The effects of a clinical ladder program on professional development and job satisfaction of acute care nurses

<h2>Research</h2> <p>Nurses play a vital role in acute care hospitals and health care delivery. The purpose of this research study is to identify the nurse&rsquo;s perception of the Clinical Ladder Program at their hospital and the correlation it has on the nurse&rsquo;s...

Research Article

Longitudinal and transverse dimensions of Hypertrophied Cardiomyocytes in human Left Ventricle (LV) at autopsy; Heart failure might result from changes in chamber geometry without contractile weakening

<h2>Abstract</h2> <p>The shapes and sizes of human cardiomyocytes are accessible to systematic observation under most circumstances only at autopsy. This constraint has seriously curbed the study of these topics, thereby leaving a crippling gap in our understanding of heart fail...

Review Article

Update on Phenobarbital for Alcohol Withdrawal Syndrome in Intensive Care

<h2>Abstract</h2> <p>Alcohol abuse is a global health problem. Alcohol withdrawal syndrome (AWS) ranges from mild to severe symptoms that can lead to fatal delirium tremens requiring ICU admission and incurring high health care cost as high as $20,000 a month. The latest publish...

Research Article

High water intake in preventing the risk of Uric Acid Nephrolithiasis: A systematic review and meta-analysis

<h2>Abstract</h2> <p><strong>Background</strong>: Hyperuricosuria, persistently low urinary pH, and low urinary volume are the main risk factors of uric acid nephrolithiasis. Epidemiologic studies suggest that high water intake is protective against the occurrence of...

Opinion

Proposal for the elimination of allergies

<h2>Opinion</h2> <p>A man I knew had an extreme allergy to poison ivy when he was a child. When he was about four-teen, he was hanging out with a group of his friends who dared him to eat some poison ivy. He did, and never got poison ivy again. Presumably, the ingestion of the a...

Research Article

A forensic treatment-monitoring study of an adult with attentiondefi cit disorder with hyperactivity and substance use disorder

<h2>Abstract</h2> <p><strong>Background:</strong> The patient in this study experienced a childhood marked by conflicts within the family, physical abuse, frequent changes of school settings, truancy, and unspecified learning disabilities. After leaving school at age...

Research Article

Non-chemical control of Armillaria mellea infection of Prunus persica

<h2>Abstract</h2> <p>Peaches, <em>Prunus persica</em> were planted as grafted saplings in an avocado orchard previously infested with <em>Armillaria mellea </em>(Vahl) P.Kumm. Trees were planted in large or small holes with or without fresh yardwaste chip...

Case Report

Glomus Tumor of the Scrotum: A Case Report

<h2>Introduction</h2> <p>Glomus tumors are rare, usually benign, lesions that arise most often in the<br /> extremities. They are derived from the glomus body and have a propensity to be found in the fingers and toes, and often in the subungual area [1]. They typically de...

Review Article

Connected Health Apps and Devices: Implications for Healthcare Delivery

<h2>Abstract</h2> <p>Healthcare is realizing the importance of health information technology - its applications and devices in play today. Advancing healthcare best practices will rely on up to date data and analysis to provide the most effective forms of therapy. Healthcare is ...

Review Article

Utilizing Pulsed Electromagnetic Field (PEMF) Therapy (Diapulse®) for Drug- Free Pain Management to Eliminate Reliance on Opioids for Non-Malignant Chronic Pain: A literature Review and Proposal for Pilot Study

<h2>Abstract</h2> <p>The Federal and State governments have declared the presence of an opioid addiction pandemic in the United States claiming the lives of more than 55,000 in 2015 (Rudd RA, Seth P, David F and Scholl L. 2016). The pharmaceutical manufacturers of the numerous F...

Research Article

Assessing the stand size of bay trees (Persea spp.) after exposure to laurel wilt disease in a North Florida Preserve

<h2>Abstract</h2> <p>Although laurel wilt disease was first reported in the United States in 2002 from redbay trees (<em>Persea borbonia</em>) around Savannah, Georgia it has rapidly spread throughout the southeastern coastal plain including Georgia and Florida. In t...

Mini Review

Handwashing in healthcare today: Why haven’t we gotten better?

<h2>Introduction</h2> <p>In 2010, a study identified that only about 40 percent of doctors and other health care providers comply with proper hand hygiene techniques in hospitals and other healthcare facilities. These statistics are alarming as healthcare professionals are the o...