Case Report

Single Trans apical access for double aortic and mitral valves-in-valves procedures with high risk of thrombus embolism

<h2>Abstract</h2> <p><strong>Background: </strong>Persistent left atrial thrombus remains a contra indication to transeptal valves in valves procedure. We aimed to perform a double valves in valves replacement through transapical access with cerebral angiography cont...

Case Report

Eosinophilic otitis media and eosinophilic asthma: Shared pathophysiology and response to anti-IL5

<h2>Introduction</h2> <p>Asthma is a highly prevalent airway disease with multiple phenotypes [1,2]. Adult-onset eosinophilic asthma is a severe asthma subtype associated with more frequent and severe exacerbations, the development of persistent airflow limitation and a poorer q...

Editorial

CRISPR genome editing: A general view

<h2>Editorial</h2> <p>CRISPR technology has presented a path forward for genomic engineering and gene modification. The framework for the use of CRISPR technology to manipulate the human genome is of great interest and the form of its development and application has excited the ...