Clinical Image

COVID-19 Associated acute limb ischemia

A 78-year-old man, known case of, diabetes mellitus, and hypertension presented with fever, dry cough and dyspnea of five-day duration.

Review Article

Multimodal treatment strategies in Huntington’s disease

Abstract

Huntington’s disease (HD) is an incurable neurodegenerative disease that causes involuntary movements, emotional lability, and cognitive dysfunction. HD symptoms usually develop between ages 30 and 50, but can appear as early as 2 or as late as 80 ...

Research Article

AsdamarinTM relieves functional dyspepsia in healthy adults in only 7 days: A randomized, double-blind, placebo-controlled pilot study

Abstract

Functional dyspepsia (FD) is a prevalent global health concern increasing with years. Inspired by the Traditional Chinese Medicine (TCM) liver-stomach disharmony syndrome in order to find a quick natural alternative treatment, a Ferula asafoetida-Silybum mar...

Research Article

Novel Coronavirus Disease (COVID-19): An extensive study on evolution, global health, drug targets and vaccines

Abstract

The Coronavirus disease-2019 (COVID-19), has become a worldwide pandemic and the scientific communities are struggling to find out the ultimate treatment strategies against this lethal virus, Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-Co...

Review Article

Role of neuron specific enolase as a biomarker in Parkinson’s disease

Abstract

Parkinson’s disease (PD) is thought to be the most common neurodegenerative disease with movement disorder. The key motor symptoms are rigidity, tremor, akinesis/hypokinesia/bradykinesia, and postural instability. However, in our day-to-day clinica...

Case Report

Organizing pneumonia as the initial presentation in rheumatoid arthritis – A case report

Abstract

Organizing pneumonia (OP), can be seen in association with lung injury, infection, drug intoxication, and connective tissue diseases. Patients of rheumatoid arthritis (RA) are prone to develop interstitial lung disease (ILD), but the pulmonary involvement us...

Review Article

Pigeonpea sterility mosaic virus a green plague-Current status of available drug and new potential targets

Abstract

Pigeonpea is one of the important legume crops with high protein content and nutritional traits. It has enormous potency for its widespread adoption by farming communities. It is affected by various kinds of biotic and abiotic stresses. In the context, of bi...

Research Article

Institutional capacity of health care institutes for diagnosis and management of common genetic diseases - A study from a north coastal district of Andhra Pradesh

Abstract

Background: In India, the genetic disease is a disregarded service element in the community health- protection system. This study aims to gauge the accessibility of services for treating genetic disorders and also to evaluate the practices on deterrence and ...

Research Article

On Friedman equation, quadratic laws and the geometry of our universe

Abstract

Einstein’s special and general relativity revolutionized physics. The predictions of general relativity are Strong Lensing, Weak Lensing, Microlensing, Black Holes, Relativistic Jets, A Gravitational Vortex, Gravitational Waves, The Sun Delaying Ra...

Research Article

Impact of COVID-19 outbreak on urology practice in India

Abstract

Background: The rapid spread of “Coronavirus Disease 2019’ (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-type 2 (SARS-CoV-2) significantly impacted health care facilities all across the globe. To assess impact on urol...

Review Article

Pulmonary Involvement in COVID-19 and ‘Long Covid’: The Morbidity, Complications and Sequelae

Abstract

Introduction: the perennial pandemic: There are serious challenges posed by the SARS-CoV-2 virus and COVID-19 as the disease. With the persistence of the pandemic over one and half year, it is being feared that the COVID-19 may have become the new reality as...

Review Article

Differential diagnosis of POLG related disorders: What to keep in mind when multiorgan system is involved?

Abstract

Mitochondrial and lysosomal dysfunction accounts for a large group of inherited metabolic disorders most of which are due to a dysfunctional mitochondrial respiratory chain (MRC) leading to deficient energy production and defects in phagocytosis in endosomal...

Review Article

Endocannabinoidome and its role in neurological disorders-A comprehensive update of existing literature

Abstract

Medical benefits of cannabis and related compounds is widely known. Discovery of psychotropic plant cannabinoid Δ9-tetrahydrocannabinol have urged researchers to study more about the cannabinoid system and related therapeutics in the field of neuro...

Review Article

A review article on artificial intelligence

Abstract

Artificial intelligence (AI) is the emulation of human intelligence in computers that have been trained to think and behave like humans. The word may also refer to any computer that exhibits human-like characteristics like learning and problem-solving. Artif...

Review Article

Orofacial manifestations of COVID-19

Abstract

Oral cavity is the gateway of the human body, and also provides vital clues of our systemic health. Here in this COVID-19 pandemic, oral manifestations such as dysgeusia, ulcers, xerostomia are noticed and are an an important predictors of this viral disease...

Research Article

Medicinal plant Potentilla fulgens and its effect in vitro against Fasciola gigantica

Abstract

Fascioliasis is a one of the most important serious parasitic zoonotic disease which caused by trematode giant liver fluke Fasciola hepatica and F. gigantica among cattle’s and humans. The infection of Fasciola can be control by the use of phytoche...

Research Article

Factors associated with mortality after decompressive craniectomy in large basal ganglia bleeds

Abstract

Aim: To assess the efficacy of decompressive craniectomy in patients with large basal ganglia (BG) bleed. To establish predictive criteria of mortality after surgery in patients with BG bleed.

Materials: This prospective study includes ...

Clinical Image

Vulvar lipoma: A rare tumour

A 26 year nulliparous woman presented to the OPD with complaint of painless swelling in the vulva for the last 1.5 years which gradually increased in size causing difficulty in walking. Physical examination revealed a well-defined soft, non-tender ellipsoidal swelling with smooth margins in...

Research Article

Donor profile and trends of eye donation in Central India

Abstract

Background: The present study was conducted to study the donor profile and to assess the trends of cornea donation.

Methodology: This was conducted as a hospital based cross sectional study at a tertiary care centre in Central India for...

Review Article

Pre-eminence and comparative analysis of skin and surface disinfectants: A systematic review to pave the way for SARS-CoV-2 prevention

Abstract

More than 200 countries have been devastated by the SARS-CoV-2 pandemic. The health workers exposed to SARS patients have been confirmed to be infected with coronavirus (SARS-CoV-2), regardless of the degree of their exposure. The increasing complexity of vi...

Review Article

A systemic review on various pertinences and simulations of rotavirus

Abstract

Rotavirus induced disease are a main source of dreadful, serious and drying out gastroenteritis in kids (less than five years old). Instead of the worldwide presentation of immunizations for rotavirus longer than 10 years back, rotavirus infections still res...

Case Report

Osteoclastic giant cell variant of urothelial carcinoma in a COVID- positive patient: A rare variant in an unusual circumstances

Abstract

Bladder carcinomas have a great propensity for divergent differentiation with more that 90% being Transitional cell carcinoma.  Several histological variants have been have described so far; they are not only morphologically unique but also have sig...

Research Article

A Study of Doppler velocimetry in pre-eclampsia patients, and their perinatal outcome

Abstract

Pre eclampsia and IUGR are important causes of maternal and perinatal morbidity and mortality. Pre eclampsia is a multisystem disorder, in normal pregnancies trophoblastic invasion transforms high resistance spiral arteries into low impedance uteroplacental ...

Research Article

Comparative study of continuous method and interrupted method of episiotomy in terms of healing of the surgical wound

Abstract

Episiotomy is a most commonly performed minor procedure. There are various type of episiotomy suturing, in this study two most common types of episiotomy suturing techniques were compare in terms of healing rate. This study concluded that the continuous meth...

Mini Review

Targeted and non-targeted effects of radiation in mammalian cells: An overview

Abstract

Radiation of different wavelengths can kill living organisms, although, the mechanism of interactions differs depending on their energies. Understanding the interaction of radiation with living cells is important to assess their harmful effects and also to ide...

Research Article

Fecal storage condition induces variations of microbial composition and differential interpretation of metagenomic analysis

Abstract

Advances in metagenomics have facilitated population studies of associations between microbial compositions and host properties, but strategies to minimize biases in these population analyses are needed. However, the effects of storage conditions, including ...

Research Article

Synergistic interactions of sperm impairing bacteria: Impact on pregnancy outcome in mouse model

Abstract

Earlier in our laboratory, the role of various individual sperm impairing microorganisms on sperm parameters and female infertility has been elucidated at higher doses. As, multiple bacterial species tend to exert more pathogenic effect in comparison to sing...

Review Article

Tunable induced transparency and Fano-resonance in double cavity optomechanical system

Abstract

We analyze optomechanically induced Transparency and asymmetric Fano-line shape Profile in a two-mode cavity system, coupling at weak and strong coupling regimes. The model system consists of one mechanical mode and two optical modes. The transmission shows ...

Case Report

A case report on Meigs’ syndrome and elevated serum CA-125: A rare case report

Abstract

Meigs syndrome is an uncommon presentation, where a benign ovarian neoplasia presents along with ascites and pleural effusion. About 1% of ovarian neoplasia can present as Meigs syndrome. Patients with Meigs’ syndrome and elevated serum CA-125 are ...

Research Article

An experimental study on effects of fluoridated water on Abelmoschus esculentus var. Soh-198 (Lady Finger)

Abstract

An experimental study of fluoride (F) accumulation in Abelmoschus esculentus var. Soh-198 and its effect on the growth and crop yield was conducted in a pot experiment. Eight different concentrations of F in the water were used for irrigation ranging from 2 ...

Research Article

Pattern of injuries in different types of victims of road traffic accident in central India: A comparative study

Abstract

Death due to road traffic accident (RTA) was one of the leading causes of mortality and morbidity in India. In the present cross-sectional study, only the victim using two-wheelers, four-wheelers, and pedestrians were included for comparison to determine the...

Review Article

Impact of COVID-19 pandemic on anti-microbial resistance and secondary microbial infections

Abstract

Corona Virus Disease-2019 (COVID-19) has become one of the most serious diseases in the history of mankind. It has captured the entire world and solutions are yet to be discovered to fight this global crisis. The outcomes of COVID-19 are influenced by a vari...

Review Article

Living with ‘Long COVID-19’: The long-term complications and sequelae

Abstract

Introduction - the perennial pandemic: It is being increasingly realised that the COVID-19 may have become the new reality associated with human existence world over and the mankind may have to live with it for years or even decades. Further, the grievous na...

Research Article

Estimation of cotinine level among the tobacco users and nonusers: A cross-sectional study among the Indian population

Abstract

Background: Epidemiological studies in smokers indicate a dose-response relationship between the number of cigarettes smoked per day and the risk of developing certain smoking related diseases. The alkaloid nicotine is the major pharmacologically active subs...

Clinical Image

Severe hypertriglycerdemia in pregnancy

31 year old female presented with abdominal pain and respiratory distress in the third trimester of her second pregnancy.

Research Article

A study of coagulation profile in patients with cancer in a tertiary care hospital

The complicated process of cancer triggers many physiological systems like vascular endothelial functions and hemostasis, which signifies the increased risk of thrombosis, which triggers thromboembolic events resulting in increased mortality and morbidity [1-3]. Tumorigenesis contributes by...

Case Report

Cholecysto-colonic fistula after xanthogranulomatous cholecystitis: Surgeon’s nightmare

Xanthogranulomatous cholecystitis is a rare benign inflammatory disease of gallbladder that may be misdiagnosed as carcinoma of the gallbladder intraoperative or in pre-operative imaging. Intramural accumulation of lipid-laden macrophages and acute and chronic inflammatory cells is the hall...

Opinion

Blood disorders: Touching of erythrocytes

In general, Erythrocytes may referred to as corpuscle (Red Blood Cells).These erythrocytes will play a significant role in our body. It carries the element round the body and produce dioxide&a...

Mini Review

Corrosive base neutralization process: Review

Summary

A balance response is the point at which a corrosive and a base respond to shape water and a salt and includes the mix of H+ particles and OH-particles to produce water. The balance of a solid corrosive and solid base has a pH equivalent to 7.

Review Article

Exploring COVID-19: Relating the spike protein to infectivity, pathogenicity and Immunogenicity

Abstract

Introduction: SARS-CoV-2 life cycle: The disease which reportedly began in Chinese city Wuhan in November-December 2019 manifesting as severe respiratory illness, soon spread to various parts of the world, and was named COVID-19, and declared a pandemic by W...

Thesis

After human: The world of brain-net on earth

“The mind of man is capable of anything….because everything in in it, all the past as well as all the future [Joseph Conrad]”. Why I am using above quote and what is the relation to what point I am coining you will understand its relevant your own as you movin...

Research Article

Chemical constituents and biological activities of Artocarpus heterophyllus lam (Jackfruit): A review

Abstract

Artocarpus (Moraceae) is a deciduous tree with appreciable importance as a source of edible fruit and is widely used in folk medicines. The extracts and metabolites of Artocarpus heterophyllus particularly those from leaves, bark, stem and fruit possess seve...

Review Article

The coral crunch: Amyloidoma

Preface

Amyloidoma is an exceptional, progressive disorder demonstrating a characteristic accumulation of significant quantities of amyloid within soft tissues. Amyloidoma is additionally nomenclated as tumoural amyloidosis, nodular amyloid or localized amyloidosis. ...

Research Article

Role of HRCT Thorax in pre-operative assessment of RT-PCR COVID-19 negative oral cancer patients

Abstract

Background: Oral cancer accounts for 30% of all types of cancer in India. Surgery is the mainstay of treatment but due to the recent outbreak of COVID-19, there is a partial or complete disruption of health services in the country. The initial delay in the tre...

Research Article

Ivabradine versus carvedilol in the management of palpitation with sinus tachycardia among recovered COVID-19 patients

Abstract

Introduction: One of the major complications among COVID-19 patients include cardiac arrhythmias. Commonest arrhythmia is sinus tachycardia which is usually associated with palpitation causing discomfort to patients. In this stud...

Review Article

The blubbery protrusions: Lipoma arborescens

Lipoma arborescens is an exceptional condition comprised of frond-like excrescences of mature adipose tissue. The condition was originally described by Albert Hoffa in 1904 with characteristic morphology of macroscopic, villous, frond- like excrescences recapitulating a tree-like appearance...

Review Article

Stages in COVID-19 vaccine development: The Nemesis, the Hubris and the Elpis

Abstract

The nemesis: SARS-CoV-2 pandemic: Leaving in its wake millions of infections, accompanied by an immense magnitude of morbidity and multitude of mortality, and an unfathomable economic toll, the COVID-19 pandemic has led to a global calamity. An effective and...

Research Article

A review on efficacy of Cissus quadrangularis in pharmacological mechanisms

Abstract

Cissus quadrangularis a succulent vine belongs to Vitaceae family is widely distributed throughout tropical and subtropical regions of the world and used frequently to various disorders. The plant has been reported to contain flavonoids, triterpenoids, phyto...

Case Report

A rare case report on pediatric shellfish allergy

Shellfish are extensively consumed worldwide because of their nutritional value. In general they are good sources of low-fat protein rich in several essential vitamins and minerals as well as in the essential nutrients omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) [1].

Review Article

Auditory effects and consequences of noise pollution in humans: A scoping review

Abstract

Noise is widespread in everyday life and can cause both auditory and non-auditory health impacts. Noise-induced hearing loss remains highly prevalent in occupational settings and is now increasingly caused by exposure to social and environmental noise. Incid...