Review Article

Flow cytometry potential applications in characterizing solid tumors main phenotype, heterogeneity and circulating cells

Abstract

Flow cytometry (FCM) is a unique technique that allows rapid quantitative measurement of multiple parameters on a large number of cells at the individual level. FCM is based on immunolabelling with fluorochrome-conjugated antibodies, leading to high sensitiv...

Research Article

Immunocompromised patients with SARS-CoV-2 infection in intensive care units, outcome and mortality

Abstract

Background: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak severely hit Northeastern France from March to May 2020. The massive arrival of SARS-CoV-2 positive patients in the intensive care units (ICU) raised the question of ho...

Research Article

An algorithm to safely manage oral food challenge in an office-based setting for children with multiple food allergies

Abstract

Background: In France, from 30% to 35% of children suffer from multiple food allergies (MFA). The gold standard to diagnosis a food allergy is the oral food challenge (OFC) which is conducted in a hospital setting due to risk of anaphylaxis.

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Clinical Image

Atypical cutaneous relapse of multiple myeloma

A 66-year-old patient, diagnosed κ light chains MM with t(11;14), presented before second cycle with bendamustine-dexamethasone.

Case Report

Facial-onset sensory-motor neuronopathy, a rare variant of Huntington’s disease or chance association?

Abstract

Objectives: To describe a patient with facial-onset sensory-motor neuronopathy (FOSMN) that later developed Huntington’s disease (HD).

Case report: A 62-year-old woman complained of progressive dysphagia 8 years before referra...

Research Article

Cystic fibrosis, the key link with airborne alpha emitting nanoparticulates

Abstract

Cystic fibrosis is explained in this paper that suggests tackling the disease by elimination of the most significant sources of contamination.

Research Article

In vitro beneficial effects of a flax extract on papillary fibroblasts define it as an anti-aging candidate

Abstract

Objective: During aging, skin undergoes structural, cellular and molecular changes, which not only alter skin mechanical properties but also biological and physiological functions. Structurally the epidermis becomes thinner, the dermal epidermal junction fla...

Research Article

Partial SHOX duplications associated with various cases of congenital uterovaginal aplasia (MRKH syndrome): A tangible evidence but a puzzling mechanism

Abstract

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most severe form of congenital malformation of the inner female reproductive tract. It is diagnosed as such when the uterus, the upper vagina and optionally the Fallopian tubes are absent. It...

Research Article

Which women uses social Internet networks during pregnancy?

Abstract

Internet has become an important part of our life, including during pregnancy where it is broadly used to find information (84%). The aims of this study were (1) to describe the proportion of women using Internet Social Networks (ISN) concerning their pregna...

Review Article

Industrial control systems: The biggest cyber threat

Abstract

Industrial control systems (ICS) are critical, as in these systems, cyber threats have the potential to affect, disorganize, change their mode of operation, act as an information extraction vehicle, and ultimately turn against itself. Creating risks to the s...

Case Report

Hemorrhagic shock due to irreducible uterine torsion in a third trimester twin pregnancy: A case report

Abstract

Uterine torsion is a rare life-threatening event that happens at any age or any gestational age. By definition, it consists of a rotation of more than 45 degrees around the long axis of the uterus. The reported cases have variable presentations. The uterine ...

Research Article

COVID-19 in pregnancy: Our experience at a tertiary maternity unit in France

Abstract

Objectives: Our main objectives are to reveal the pregnancy and neonatal impacts of COVID-19 infection and to compare it to the results that are reported in the literature.
Methods and materials: The characteristics ...

Research Article

Preventive treatment in an osteoporotic femoral upper metaphysis-A clinical case: Me Louise V…

In 1992, a patient, born July 10, 1910, aged 82, with major osteoporosis [1-3], was operated on her left hip. The surgeon performs a biomaterial transplant using natural coral [4]. Follow-up is two years. She died in 1994 of acute respiratory failure. Three bone graft osteodensitometry [5] ...

Case Report

Acute and post burn reconstructive surgery of the female trunk with artificial dermis to facilitate healthy pregnancy

The sequelae of deep and extensive burns to the abdomen can lead to serious complications during pregnancy. Studies and publications covering this subject are scarce and outdated. The complications described arise during the 3rd trimester of pregnancy, and surgical treatments to address the...

Research Article

Effects of highest dose of sacubitril/valsartan association compared to lower doses on mortality and ventricular arrhythmias

Abstract

Background: Sudden cardiac death is a major healthcare issue in reduced ejection fraction heart failure (HFrEF) patients. Recently, the new association of sacubitril/valsartan showed a reduction of both ventricular arrhythmias (V...

Short Communication

Detection limit of a lutetium based non-paralizable PET-like detector

Abstract

The effect of the intrinsic lutetium radioactivity on the detection performances of a LYSO based in-beam PET-like prototype used for quality control of hadrontherapy treatments is studied. This radioactivity leads to a background that degrades the measuremen...

Editorial

Biological markers of oxidative stress in exhaled air

Editorial

Oxidation reactions produce, through complex intermediate steps, small energy packages that are more easily stored than a sudden combustion oxidation. The slow and controlled production of energy in a nuclear power plant allows its use, a massive explosion ...

Letter to the Editor

Evaluation in real life of the impact of photo-protection counseling in patients with actinic keratosis

Dear Editor

Actinic keratosis (AK) are scaly lesions caused by chronic ultraviolet-induced damage to the epidermis which are a proxy for excessive sun-exposure [1] that may evol...

Case Report

Resolved complete atrioventricular block and left ventricular severe dysfunction in patient with Wegener’s granulomatis after cyclophosphamide and corticosteroid treatment

Introduction

Wegener’s granulomatosis is a systemic granulomatous focus on small to medium sized vessels. It typically affects sinuses, lungs and kidneys due to necrotizing granulomatous vasculitis. Less commonly, cardiac involvement is reported up to 8%-44...

Case Report

Cranio-Facial Fibrous Dysplasia: A case report of a conservative treatment in a monostotic form associated with an orthodontic management and a bone graft of the non-lytic bone area for dental implant rehabilitation

Abstract

Fibrous dysplasia is an osteolytic lesion in which bone is replaced by an instable fibrous osseous tissue. The aim of this case report is to highlight dental rehabilitation (bone grafts to allow dental implant) on patients suffering of this condition.

Research Article

Effect of intradialytic physical activity on the quality of life, biological parameters and sleep in hemodialysis patients

Abstract

Many side effects, in addition to those of the pathology itself, have occurred with hemodialysis treatment but existing literature have shown that physical activity is beneficial to hemodialysis patients. Nevertheless, our parameters have not been studied en...

Research Article

Effect of laparoscopic salpingectomy on subsequent ovarian response after controlled ovarian hyperstimulation

Abstract

Background: The effect of salpingectomy on ovarian response is a matter of debate. Due to conflicting data, alternative techniques were developed to perform salpingectomy for treatment of hydrosalpinges in infertile patients. Thi...

Research Article

The place of health innovation in space to improve the lives of earthlings

For over twenty years, following the creation of space stations, MIR first and then the ISS (International Space Station) men (3 to 6) live and succeed each other continuously about 300 - 400 km of altitude to make scientific experiments. For this reason sending men into space has become an ac...

Research Article

Assessment of shoulder pain and somatic dysfunction in young competitive swimmers: Preventive Osteopathic Manipulative Treatment

Abstract

Context: Shoulder pain is one of the most frequent reported complaints in intensive competitive swimming. The so-called ‘swimmers’ shoulder’ has been widely explored and has been reported sometimes w...

Research Article

Preclinical stiff heart is a marker of cardiovascular morbimortality in apparently healthy population

Abstract

Background: The prognostic signifi cance of impaired left ventricular (LV) relaxation and increased LV stiffness as precursor of heart failure with preserved ejection fraction and death is still largely unknown in apparently heal...

Case Report

The forgotten player in the surgical history

Abstract

The research concerning a preventive treatment of an osteoporitic femoral neck fracture started in 1990 because the surgical procedure of unstable femoral neck fractures is difficult. After effects are frequent and their number will increase in the next deca...

Mini Review

An analysis of wild animals with respect to French Ethics and Law

Introduction

Before discussing the crux of the matter, it is important to understand what “wild” signifies and the characteristics that define a wild animal.

As contrasted to domesticated animals, a wild animal can be defined...

Research Article

Diagnostic accuracy of TIMI versus GRACE score for prediction of death in patients presenting with Acute Non-ST Elevation Myocardial Infarction (NSTEMI)

Abstract

Background: Acute Coronary Syndrome describes a spectrum of disease ranging from unstable angina through non-ST-Elevation Myocardial Infarction (NSTEMI) to ST-Elevation Myocardial Infarction (STEMI). Early death in NSTEMI is usua...

Review Article

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Abstract

Purpose: The benefits of Physical Activity (PA) considered as a major supportive care in cancer patients, on survival, and recurrence risk is largely disseminated in public communication. However, these data must be taken with ca...

Clinical Image

Chronic recurrent bilateral granulomatous iridocyclitis in an 18-year-old woman

Clinical Image

A case of recurrent tuberculosis-related uveitis in a young female patient of North African origin.

Right eye: Slit-lamp photograph of broad-based posterior synechiae (formed by macrophage-laden iris tissue when brushing against a...

Case Report

Addiction to self-strangulation: a case-report

Abstract

Introduction: DSM-5 mentions autoerotic asphyxia in the paraphilic disorders section, as a specifier for the diagnostic of sexual masochism disorder. Strangulation activities have also been observed in the “choking game...

Research Article

Comparative Hemodynamic Evaluation of the LUCAS® Device and Manual Chest Compression in Patients with Out-of-Hospital Cardiac Arrest

INTRODUCTION

Chest compression is the fundamental technique in cardiopulmonary resuscitation (CPR) in patients with cardiac arrest [1]. The quality and the early implementation of CPR are essential to improve the prognosis and the chances of restoring spontaneous cir...

Case Report

A Short Synthesis Concerning Biological Effects and Equivalent Doses in Radiotherapy

ABSTRACT

The limits of classical equivalent computation based on time, dose, and fractionation (TDF) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the...

Research Article

Analysis of early Versus Delayed Carotid Surgery after Acute Ischemic Stroke

ABSTRACT

Objective: We evaluated the 30-day outcomes of early (≤ 14 days) or delayed (15 days to three months) carotid revascularization (CR) performed in patients who presented acute brain infarction secondary to internal carotid ...

Research Article

The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location

Abstract

When Total Hip Arthroplasty (THA) is required in a patient with developmental dysplasia of the hip (DDH), bone deficiency in the acetabular roof often remains a problem. The iliac crest (IC) has long been the preferred source of autograft material, but graft...