Review Article

A proposed mechanism to explain increases in intracranial pressure: The concept of cerebral artery wedge pressure

<h2>Abstract</h2> <p>We hypothesize that, with elevated cerebral spinal fluid (CSF) pressure, cerebral micro-vascular obstruction and congestion may occur despite (subdural) large-vein pressures being normal. Smaller veins emptying into these larger, dura-enveloped veins are not...

Research Article

Histological clonal change - A feature for dysplasia diagnosis

<h2>Abstract</h2> <p><strong>Aims:</strong> Histological diagnostic criteria are used for the assessment of the degree of dysplasia and hence the risk of cancer progression for premalignant lesions. Clonal changes in the form of hyperorthokeratosis and hyperchromasia...

Research Article

Rehabilitation of proximal humerus fractures: An environmental scan of Canadian physiotherapy practice patterns

<h2>Abstract</h2> <p><strong>Background:</strong> Proximal humerus fractures (PHFs) are common injuries particularly in older adults. Evidencebased protocols for PHF rehabilitation are lacking and physiotherapists use a variety of interventions.</p> <p>...

Review Article

The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy

<h2>ABSTRACT</h2> <p>Since the discovery of the dystrophin gene (DMD gene) thirty years ago, several therapeutic approaches have been investigated to treat Duchenne muscular dystrophy (DMD). This includes cell therapy, exon jumping, exonic knockout, and the CinDel method. In thi...

Research Article

Translating an Evidence-Based Physical Activity Service From Context To Context: A Single Organizational Case Study

<h2>Abstract</h2> <p><strong>Background:</strong> SCI Action Canada partnered with researchers to adapt an evidence-based leisure-time physical activity (LPTA) counselling service (Get-in-Motion (GIM). A satellite GIM service called Passez &agrave; l&rsquo;ac...